A5037584672- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Hereditary Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Systemic Lupus Erythematosus Research
- Myasthenia Gravis and Thymoma
- Autoimmune Neurological Disorders and Treatments
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Nerve Disorders
- Ion channel regulation and function
- Structural Integrity and Reliability Analysis
- Adenosine and Purinergic Signaling
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Cell Adhesion Molecules Research
- Polyomavirus and related diseases
- Parkinson's Disease Mechanisms and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Neuroscience of respiration and sleep
- Fluid Dynamics Simulations and Interactions
- Hearing, Cochlea, Tinnitus, Genetics
- solar cell performance optimization
- Respiratory and Cough-Related Research
Chiba University
2015-2024
Kitasato University
2014-2023
Chiba University Hospital
2009-2023
National Hospital Organization
2006-2021
Neurology, Inc
2021
Chiba Institute of Science
2007-2020
Hokkaido University
2020
Kyoto University
2019
Japan Science and Technology Agency
2014-2017
Hyogo University of Health Sciences
2014-2017
The authors reviewed the clinical features and outcome of Miller Fisher syndrome (MFS) for 50 consecutive patients with MFS including 28 who received no immunotherapy. Besides characteristic triad (ophthalmoplegia, ataxia, areflexia), pupillary abnormalities, blepharoptosis, facial palsy are frequent in MFS, whereas sensory loss is unusual despite presence profound ataxia. Patients usually had good recovery residual deficits.
Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking. Objective: To investigate the contribution of cytokines/chemokines pathogenesis NMO. Methods: We measured 27 Th17 cell-associated cerebrospinal fluid (CSF) 31 NMO, 29 MS 18 other non-inflammatory neurological disorders patients. The serum levels some cytokines/ were also measured. correlations between clinical...
To clarify the relations of axonal form Guillain-Barré syndrome (GBS) to anti-ganglioside antibodies and Campylobacter jejuni infection, 86 consecutive Japanese GBS patients were studied. Electrodiagnostic criteria showed acute inflammatory demyelinating polyneuropathy in 36% motor neuropathy (AMAN) 38%. Frequent IgG class against GM1 (40%), GD1a (30%), GalNAc-GD1a (17%), GD1b (21%). Identified infections C. (23%), cytomegalovirus (10%), Mycoplasma pneumoniae (6%), Epstein-Barr virus (3%)....
Electrophysiological and pharmacological properties of glycine receptors were characterized in hippocampal organotypic slice cultures. In the presence ionotropic glutamate GABA B receptor antagonists, pressure‐application onto CA3 pyramidal cells induced a current associated with increased chloride conductance, which was inhibited by strychnine. Similar currents could also be β‐alanine or taurine. Whole‐cell responses significantly greater than CA1 dentate granule cells, while to similar...
Neuromyelitis optica (NMO) is presumably mediated by an autoantibody against aquaporin-4 densely expressed at the blood-brain barrier. In 18 patients with NMO, brain magnetic resonance imaging (MRI) findings were systematically reviewed. Brain MRI abnormalities found for 89% of patients, and most prominent feature was "cloud-like enhancement," multiple patchy enhancing lesions blurred margin, in 90% positive contrast enhancement. are frequent, cloud-like enhancement appears to be finding...
Lipid droplets (LDs) function as intracellular storage depots of neutral lipids. Recently, we identified long-chain acyl-coenzyme A synthetase 3 (ACSL3) a major LD-associated protein in the human hepatocyte cell line HuH7. In this study, investigated whether droplet-associated ACSL is involved lipid metabolism LDs. Addition oleic acid (OA) to culture medium was shown enhance accumulation LDs cells, which accompanied by an increase droplet ACSL3. When LD-enriched cells induced OA were further...
Background: Spinal magnetic resonance imaging (MRI) finding of longitudinally extensive spinal cord lesions (LESCL) extending over three vertebral segments and involvements central gray matter have been reported in patients with neuromyelitis optica (NMO). Objectives: We aimed to review MRI findings NMO multiple sclerosis (MS), determine whether the “bright spotty lesions” (BSLs) are a discriminative NMO. Methods: For this study, 24 consecutive 34 MS were enrolled. BSLs defined as very...
<h3>Background</h3> Chronic inflammatory demyelinating polyneuropathy (CIDP) is currently classified into 'typical' CIDP and 'atypical' subtypes such as multifocal acquired sensory motor neuropathy (MADSAM). <h3>Objectives</h3> To assess the frequency of subtypes, to elucidate clinical electrophysiological features, treatment response in each subtype. <h3>Methods</h3> We reviewed data from 100 consecutive patients fulfilling criteria for proposed by European Federation Neurological Societies...
1 A fast ATP-mediated synaptic current was identified in CA3 pyramidal cells organotypic hippocampal slice cultures. In the presence of inhibitors for ionotropic glutamate and GABA receptors, extracellular stimulation cell layer evoked currents that reversed near 0 mV, reflecting an increase a non-selective cationic conductance. This response mimicked by focal application ATP. Antagonists P2X receptors reduced both ATP-induced currents. 2 Using pharmacological approach, source synaptically...
We analyzed clinical recovery of 92 patients with Miller Fisher syndrome who had been treated IV immunoglobulin (IVIg; n = 28), plasmapheresis (n 23), and no immune treatment 41). IVIg slightly hastened the amelioration ophthalmoplegia ataxia, but times disappearances those symptoms were similar among three groups. In syndrome, seem not to have influenced patients9 outcomes, presumably because good natural recovery.
Background: Although the benefit of treatment for relapsing–remitting multiple sclerosis (MS) is firmly established, whether interferon beta‐1b (IFNB‐1b) therapy efficacious neuromyelitis optica (NMO) has been debated. Methods: We reviewed responses to IFNB‐1b in 18 patients with relapsing NMO and compared results those from 38 MS. clinical characteristics, annualized relapse rate (ARR) probability being free before after Results: The proportion more than 50% increase ARR was much higher MS...
TAR DNA binding protein of 43 kDa (TDP-43) is likely to be the major pathogenetic in amyotrophic lateral sclerosis (ALS). A previous study has shown that levels TDP-43 CSF measured by an ELISA are significantly higher for ALS patients than controls. The aim this was investigate whether elevated specific ALS, and associated with clinical profiles patients. We same 27 50 neurodegenerative or inflammatory disease controls such as Parkinson's disease, multiple sclerosis, Guillain-Barré syndrome.