A5023253294- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Multiple Sclerosis Research Studies
- Peripheral Nerve Disorders
- Acute Ischemic Stroke Management
- Myasthenia Gravis and Thymoma
- Venous Thromboembolism Diagnosis and Management
- Autoimmune Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Systemic Sclerosis and Related Diseases
- Parkinson's Disease and Spinal Disorders
- Kidney Stones and Urolithiasis Treatments
- Dermatological and Skeletal Disorders
- CNS Lymphoma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiomyopathy and Myosin Studies
- Neurogenetic and Muscular Disorders Research
- Infectious Encephalopathies and Encephalitis
- Vasculitis and related conditions
- Moyamoya disease diagnosis and treatment
- Muscle Physiology and Disorders
- Cerebrovascular and genetic disorders
- Peroxisome Proliferator-Activated Receptors
- Nerve injury and regeneration
Hiroshima Prefectural Hospital
2022-2024
Hiroshima University
2014-2024
Hiroshima City Asa Citizens Hospital
2020-2023
North Medical Center
2023
Hiroshima University Hospital
2013-2016
Therapeutics Clinical Research
2014
Okayama Central Hospital
2013
Ehime University
1981-2011
Kindai University
2011
Kyushu University
2011
Arachidonate 5-lipoxygenase was isolated from guinea pig peritoneal polymorphonuclear leukocytes, and partially purified a high speed supernatant of homogenate.5-Hydroperoxy-6,8,11,14-eicosatetraenoic acid predominant reaction product.The enzyme required specifically calcium ion (20 pM for half-maximal activity), other divalent cations such as magnesium cobalt were ineffective.The calcium-dependent stimulated by several nucleotides, most prominently ATP in the order 1...
Dysphagia occurs in acute stroke patients at high rates, and many of them develop aspiration pneumonia. Team approaches with the cooperation various professionals have power to improve quality medical care, utilizing specialized knowledge skills each professional. In our hospital, a multidisciplinary participatory swallowing team was organized. The aim this study clarify influence approach on dysphagia by comparing rates pneumonia prior post organization. All consecutive who were admitted...
HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype-phenotype in 528 MS 165 NMOSD cases using Japan MS/NMOSD Biobank materials. HLA-DRB1*04:05, DRB1*15:01 DPB1*03:01 correlated with susceptibility DRB1*01:01, DRB1*09:01, DRB1*13:02 DPB1*04:01 were protective against MS. HLA-DRB1*15:01 was associated increased optic neuritis cerebellar involvement worsened visual...
It is not known whether autonomic neuropathy a feature of Sjögren's syndrome (SS) or it related to circulating antiganglionic acetylcholine receptor (gAChR) antibodies. The goal the present study was investigate dysfunction in patients with SS and associations between dysfunction, anti-gAChR antibodies, clinical features SS.(1) first observational tested for presence gAChR antibodies serum samples from 39 (absent information regarding symptoms) healthy volunteers. (2) In second study,...
ObjectiveThe aim of the RIN-2 study was a compassionate use rituximab (RTX) for patients who completed RIN-1 study, multicentre, randomised, double-blind, placebo-controlled trial RTX. We also investigated long-term safety and efficacy RTX.MethodsA design prospective open-label extension following study. RTX infused repeatedly under monthly monitoring CD19-positive CD 20-positive B cell lymphocyte subsets from 24 weeks after an infusion.ResultsThirty-three (87%) 38 were enrolled February...
A recent genome-wide survey identified non–human leukocyte antigen ( HLA ) genes that are related to multiple sclerosis (MS). Among these, an association of a single nucleotide polymorphism (SNP), rs6897932, in the interleukin-7 receptor α gene IL-7RA with MS susceptibility has been widely replicated Caucasians.1,–,3 The SNP located transmembrane domain IL-7Rα is nonsynonymous and functional: MS-susceptible CC allele increases levels soluble form via exon skipping, decreases expression...
Six patients unexpectedly presented with Japanese encephalitis (JE) from early August to mid-September 2002 in the Chugoku district of Japan. The mean age was 67.5 years (range 42 - 89 years); onset period two shifted middle September. JE virus isolated cerebrospinal fluid samples patients, and strain one identified as genotype III. Neurologically, consciousness impairment, meningeal signs, rigidity, hemiparesis, tetraparesis, convulsive seizures were commonly observed. Magnetic resonance...
A major high molecular weight protein (HMP) in the cytoskeletal fraction from pea has been purified. combination of chromatographic techniques and protease fragment analysis also facilitated isolation encoding cDNA, disclosing sequence complete open reading frame. The possesses four N-terminal Staphylococcal nuclease (SNc) domains, a central Tudor domain partial SNc at C-terminus, which may act as coiled-coil cytoskeleton interaction motif. Cell fractionation studies showed that was abundant...
Diabetic hemichorea-hemiballism with non-ketotic hyperglycemia is usually a benign syndrome. Here, we report 78-year-old woman persistent hemichorea (HC) for longer than 1 year recurrence after rapid correction of hyperglycemia. Following the disappearance characteristic T1 hyperintensity at 3 months onset, an MRI demonstrated T2* hypointensity and atrophic changes in contralateral striatum, suggesting irreversible neuronal loss some vascular proliferation. The electrophysiological...
Intravenous immunoglobulin (IVIg) therapy is currently the only established treatment in patients with multifocal motor neuropathy (MMN), and many have an IVIg‐dependent fluctuation. We aimed to investigate efficacy safety of every 3 week IVIg (1.0 g/kg) for 52 weeks. This study was open‐label phase clinical trial, enrolling 13 MMN patients. After induction (0.4 g/kg/d 5 consecutive days), maintenance dose given weeks The major outcome measures were Medical Research Council (MRC) sum score...
Background: The G allele of NOTCH4 rs422951 is protective against demyelinating disease in Japanese. Objectives: purpose this study was to assess the relation neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) and multiple sclerosis (MS) interaction between HLA-DRB1 alleles, clarify any association with clinical features. Methods: DNA sequencing used genotype 106 NMO/NMOSD patients, 118 MS patients 152 healthy controls (HCs) for rs422951. Results: frequency but not that lower than HCs...