A5039646427- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Oral microbiology and periodontitis research
- Peripheral Neuropathies and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- HIV/AIDS oral health manifestations
- Botulinum Toxin and Related Neurological Disorders
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Ear Surgery and Otitis Media
- Full-Duplex Wireless Communications
- Salivary Gland Disorders and Functions
- Hereditary Neurological Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Cerebrospinal fluid and hydrocephalus
- Parasite Biology and Host Interactions
- Extracellular vesicles in disease
- Polyomavirus and related diseases
- Hemiptera Insect Studies
- Neurofibromatosis and Schwannoma Cases
Fukuoka International University
2021-2025
International University of Health and Welfare
2021-2025
Fukuoka Hospital
2021-2024
Kyushu University
2017-2021
Asan Medical Center
2021
University of Ulsan
2021
Ulsan College
2021
Japanese Red Cross Hiroshima College of Nursing
2015-2016
Aso Iizuka Hospital
2014
Abstract Aim Oral microflora during pregnancy is critical to oral health care in the mother and her child. We examined changes microbiota between nonpregnancy periods. Methods The study was performed using 132 healthy pregnant women enrolled from Hiroshima City Asa Citizens Hospital 51 nonpregnant as control. During pregnancy, subjects were assessed for seven microbial species by cultured method polymerase chain reaction at early (7–16 weeks gestation), middle (17–28 weeks), late (29–39...
HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype-phenotype in 528 MS 165 NMOSD cases using Japan MS/NMOSD Biobank materials. HLA-DRB1*04:05, DRB1*15:01 DPB1*03:01 correlated with susceptibility DRB1*01:01, DRB1*09:01, DRB1*13:02 DPB1*04:01 were protective against MS. HLA-DRB1*15:01 was associated increased optic neuritis cerebellar involvement worsened visual...
Abstract Objectives To assess blood exosome (Ex)‐connexin (Cx)43 (encoded by GJA1 ) and its truncated isoforms in multiple sclerosis (MS) neuromyelitis optica spectrum disorder (NMOSD), which show distinct alterations astroglial Cx43. Methods Serum Exs from 48 patients with MS (34 relapsing–remitting, 14 secondary‐progressive), 35 NMOSD, 20 other inflammatory neurologic diseases (OIND), 17 healthy controls (HC) were subjected to quantitative Western blotting for Cx43, single‐molecule array...
<h3>Objectives</h3> To assess the prevalence of antiplexin D1 antibodies (plexin D1-immunoglobulin G [IgG]) in small fiber neuropathy (SFN) and effects these vivo. <h3>Methods</h3> We developed an ELISA for plexin D1-IgG using a recombinant extracellular domain human containing major epitope sera from 58 subjects previously studied with standard tissue-based indirect immunofluorescence assay (TBA). screened 63 patients probable SFN 55 healthy controls (HCs) serum ELISA. The results were...
The cervical and thoracic cross-sectional spinal cord area (CS-SCA) in multiple sclerosis (MS) correlates with disability, whilst such a correlation remains to be established neuromyelitis optica spectrum disorder (NMOSD). Our aim was clarify differences between MS NMOSD segments where CS-SCA is associated disability.The at C2/C3, C3/C4, T8/T9 T9/T10 vertebral disc levels measured 140 patients (111 relapsing-remitting 29 progressive MS) 42 anti-aquaporin-4 immunoglobulin G. Disability...
症例は64歳男性である.1998年に頭部を打撲し慢性硬膜下血腫を来した既往がある.2000年から頭痛,ふらつき,聴力低下が出現し緩徐に増悪した.2011年,他院精査で血性髄液を認め,MRIでT2/T2*強調画像にて脳・脊髄表面に沿った低信号病変を認めた.脳表ヘモジデリン沈着症と診断されるも出血源は不明で,止血剤も無効であった.2015年当科受診時,水平性注視方向性眼振,両側高度感音性難聴,四肢・体幹失調を認め,MRIではCISS法にてTh2~3レベル硬膜前面に欠損を認めた.硬膜欠損に対して硬膜欠損閉鎖術を行ったところ,血性髄液の改善を認め,術後頭痛,失調の改善を認めた.
Abstract Background Progressive multifocal leukoencephalopathy (PML) caused by JC virus (JCV) is a rare but serious complication of some disease-modifying drugs used to treat multiple sclerosis (MS). Japanese MS patients treated with fingolimod were reported be 10 times more likely develop PML than equivalent in other countries. The strongest susceptibility human leukocyte antigen ( HLA ) class II alleles for are distinct between races DRB1*15:01 Caucasians and DRB1*04:05 Japanese);...
To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG three MAP peptides two homologous were measured in sera from 103 MS patients 50 healthy controls (HCs). had higher levels MAP2694295-303 (MAP2694-IgG) than HCs, while the other antibodies comparable. Multivariate analysis demonstrated that MAP2694-IgG titers associated with EDSS...
A 61-year-old man presented with a 4-month history of progressive vision loss and paresthesia between the right L2-L4 dermatome. Funduscopy revealed severe bilateral papilledema (figure 1). Head CT showed mild hydrocephalus. CSF from lumbar puncture at L4-L5 level was xanthochromic an elevated protein (4,350 mg/dL). Lumbar spine MRI demonstrated large intradural tumor L3-L4 2), which pathologically identified as schwannoma. Surgical removal resolved all symptoms. Papilledema is rare...
The prevalence of periodontal disease among pregnant women increases with gestational age. Therefore, oral health education in the early stage pregnancy should prevent and decrease risk an adverse outcome such as preterm delivery low birth weight. However, there has been no study on care intervention for prevention during pregnancy. purpose this was to examine efficiency program Japanese low-risk women. A total 207 before 20 weeks gestation were recruited. first 131 them assigned control...
We report the case of a 74-year-old woman with Parkinson's disease (PD) who developed acute dysphagia, dysarthria, and hoarseness. A neurological examination nasopharyngeal fiberscopy revealed paralysis left glossopharyngeal, vagus, hypoglossal nerves. No skin rash was observed. Cerebrospinal fluid testing showed lymphocytic pleocytosis, an elevated varicella-zoster virus (VZV) IgG antibody index. She diagnosed zoster sine herpete unilaterally affecting multiple lower cranial Although...
Multiple sclerosis (MS), the most prevalent inflammatory disease of central nervous system (CNS), is characterized by damaged to myelin sheaths and oligodendrocytes. Because MS patients have variable clinical courses severities, it important identify biomarkers that predict activity severity. In this study, we assessed frequencies serum autoantibodies against mature oligodendrocytes in using a tissue-based immunofluorescence assay (IFA) determine whether anti-oligodendrocyte antibodies are...