A5082223132- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Powdery Mildew Fungal Diseases
- Acute Ischemic Stroke Management
- Amyotrophic Lateral Sclerosis Research
- Autoimmune Neurological Disorders and Treatments
- Polyomavirus and related diseases
- Medical Imaging Techniques and Applications
- Systemic Sclerosis and Related Diseases
- Neurological Complications and Syndromes
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Olfactory and Sensory Function Studies
- Rheumatoid Arthritis Research and Therapies
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood Pressure and Hypertension Studies
- Parkinson's Disease and Spinal Disorders
- Urban and spatial planning
- Congenital Diaphragmatic Hernia Studies
- Ocular Diseases and Behçet’s Syndrome
Tokyo Women's Medical University
2013-2024
Tokyo Women's Medical University Yachiyo Medical Center
2012-2024
Jichi Medical University
2024
Hamamatsu University School of Medicine
2024
National Hospital Organization Saitama Hospital
2012
Keio University
2012
National Hospital Organization
2012
University Gastroenterology
2011
Aichi Medical University
2011
Showa General Hospital
2006
Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated several factors such as depression fatigue. This study aimed to evaluate in Japanese MS the association between apathy, fatigue, depression. The Brief Repeatable Battery Neuropsychological tests (BRB-N) was performed 184 163 healthy controls matched age, gender, education. Apathy Scale (AS), Fatigue Questionnaire (FQ), Beck Depression Inventory Second Edition...
Few reports describe the influence pregnancy has on annualized relapse rate (ARR) in neuromyelitis optica spectrum disorder (NMOSD).To examine pregnancy-related attacks (attacks during or within 1 year postpartum) and identify risk factors for an attack Japanese NMOSD patients.We retrospectively reviewed 139 women whom had aquaporin-4 (AQP4) antibody-positive NMOSD. Among 114 patients with information, 47 56 pregnancies. We compared ARR before, after pregnancy.Of pregnancy, 22 (46.8%) a of...
No large-scale studies have compared the efficacy of intravenous methylprednisolone pulse therapy (IVMP) for multiple sclerosis (MS) and neuromyelitis optica (NMO).To explain differences in treatment responses MS NMO patients to IVMP.Changes neurological symptoms/signs Expanded Disability Status Scale (EDSS) scores before within 1 week IVMP completion were obtained 2010 at 28 institutions, retrospectively collated from 271 (478 courses) 73 (118 cases.In patients, decreased EDSS score was...
Odor impairment and its relationship with TAR DNA-binding protein 43 (TDP-43) pathology in patients amyotrophic lateral sclerosis (ALS) have not been fully elucidated. We performed the odor stick identification test for Japanese (OSIT-J) 18 ALS controls. The score was significantly decreased (6.6 ± 2.7) versus controls (9.2 2.4) (U = 77.0, p 0.007). This decrement of OSIT-J paralleled cognitive decline. then studied samples from a series 42 postmortem cases. Quantitative analyses...
HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype-phenotype in 528 MS 165 NMOSD cases using Japan MS/NMOSD Biobank materials. HLA-DRB1*04:05, DRB1*15:01 DPB1*03:01 correlated with susceptibility DRB1*01:01, DRB1*09:01, DRB1*13:02 DPB1*04:01 were protective against MS. HLA-DRB1*15:01 was associated increased optic neuritis cerebellar involvement worsened visual...
<b><i>Background:</i></b> MS is a chronic inflammatory disease of the CNS postulated to be Th1 type cell–mediated autoimmune disease. There increased interferon-γ (IFNγ) secretion in MS, and IFNγ administration induces exacerbations expression closely regulated by number cytokines produced different cells immune system. Interleukin-12 (IL-12) major factor leading Th1-type responses, including secretion, there IL-12 MS. IL-10 potent inhibitor both expression. <b><i>Methods:</i></b> The...
The Brief International Cognitive Assessment for MS (BICAMS) is a practical battery measuring cognitive function in multiple sclerosis (MS).We aimed to validate Japanese version of the BICAMS patients with and healthy controls.The Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-Second Edition (CVLT2) Visuospatial Memory Revised (BVMTR) were administered 156 126 controls (HCs). was re-administered subset 27 30 HCs.The mean (±SD) raw scores HC groups as follows: SDMT: 47.9...
日目には小脳失調，構音障害が出現し，頭部 MRI で右小脳半球および右基底核に新規病変がみられたた め，同院に入院した．IVMP で症状は順調に改善し，退院し た．経口ステロイド剤による後療法は行われておらず，脳脊 髄液検査が行われたかどうかは不明である．その後は明らか な再発はなく，頭部 上も FLAIR 高信号は消退した． 2014 年 2 月某日(17 歳時)に全身強直性痙攣，右不全片麻 痺，失語が出現し，当院小児科に入院した．脳脊髄液検査で 単核球優位の細胞増多(細胞数 137/μl，単核球 73％)があり， オリゴクローナルバンド(oligoclonal band; OCB)は陽性でミ エリン塩基性蛋白(myelin basic protein; MBP)は 31.3 pg/ml 未満であった．脳波では左半球優位，前頭葉優位に高振幅δ 症例報告 片側大脳皮質脳炎を生じた抗 MOG 抗体陽性多相性散在性脳脊髄炎の 1 例 福嶋 直弥 1) 鈴木 美紀 小川 諒 2) 林 北見 3) 高梨 潤一 大橋 高志 * 要旨： 症例は 20 歳女性．11...
A 36-year-old man was admitted to our hospital because of urinary retention and muscle weakness affecting all 4 limbs after receiving a H1N1 09 influenza vaccination. Magnetic resonance imaging demonstrated multiple lesions in his brain spinal cord. Furthermore, nerve conduction study showed acute sensorimotor neuropathy, anti-GM2 antibodies were detected serum. Based on the temporal association exclusion alternative etiologies, we made diagnosis disseminated encephalomyelitis (ADEM)...
In this article, we report the third case of chloride voltage-gated channel 2 (CLCN2)-related leukoencephalopathy (CC2L) in Japan. The patient presented with headache, vertigo, and mild visual impairment. CLCN2 variant patient, NM_004366.6:c.61dup, p.(Leu21Profs*27), was also found two other Japanese patients as is relatively common population. Magnetic resonance imaging (MRI) revealed T2 prolongation reduced diffusion bilateral posterior limbs internal capsule, cerebral peduncles, superior...
Multiple sclerosis (MS) is a putative autoimmune disease that linked with HLA-DR2,w15. Proteolipid protein (PLP) candidate autoantigen in MS, but the disease-associated epitopes have not been determined. Using overlapping and non-overlapping PLP peptides, we studied T cell response to major hydrophilic domain 85-159 peripheral blood of MS healthy subjects (HS). Short-term lines (TCL) were selected against each peptide using microwell plates frequency peptide-specific TCL was estimated....
We evaluated 30 patients with clinically definite multiple sclerosis (MS) and 8 neuromyelitis optica (NMO) to investigate correlations between Th1/Th2 balance, disease activity, effects of interferon (IFN)-β treatment, expressions chemokine receptors CXCR3 CCR4 on CD4+ CD8+ T cells in peripheral blood. MS NMO the relapsing phase showed a significantly increased CD4+CXCR3+/CD4+CCR4+ ratio CD8+CXCR3+/CD8+CCR4+ compared respective remission phase. After IFN-β were decreased slightly lower than...
A 70-year-old man presented with sudden onset of global aphasia and right hemiplegia. Brain MRI revealed occlusion the left middle cerebral artery. He was diagnosed as having a hyperacute infarction. Intravenous thrombolytic therapy started, neurological symptoms were resolved after 11 h. Echocardiography showed mobile mass in atrium, suspicious myxoma. The tumor resected pathologically In this patient, intravenous effective, no adverse effects observed. This suggests that, even...
To clarify a possible contribution of TDP-43 pathology to odor dysfunction in amyotrophic lateral sclerosis patients.An 83-year-old woman suffered from muscle weakness, which started deteriorate during the previous half year. In addition her pyramidal signs, lower motor involvement was shown by needle electromyography; this upper and neuron suggestive probable ALS. She presented with severe impairments but relatively preserved cognitive functions. Her autopsy findings revealed...
Abstract Objectives There has been no large‐scale study of methylprednisolone pulse therapy in A sian patients with multiple sclerosis ( MS ) or neuromyelitis optica NMO ), despite it being widely used for acute relapse. We aimed to clarify treatment response and post‐pulse oral corticosteroids real clinical practice a multicenter Japan. Methods Investigators at 28 institutions collected changes neurological symptoms/signs E xpanded D isability S tatus cale EDSS scores before within 1 week...
Although clonal expansion of autoimmune T cells has been reported in multiple sclerosis (MS), very limited information is available on specificities, size, or activation state the expanded clones. Here we address issue by using a novel technique demonstrating clonotypes defined single-strand conformation polymorphism TCR beta-chain cDNAs. Examination activated (CD3+CD25+) isolated from peripheral blood MS revealed numbers (20 approximately 82) clones clonotype. To estimate Ag specificities...
In the pathogenesis of multiple sclerosis (MS), autoimmune T cells reactive with proteolipid protein (PLP) may play a crucial role. We determined 23 TCR beta-chain sequences limiting dilution cel lines (TCL) selected against synthetic peptide, PLP 95-116, 105-124 or 139-155, from peripheral blood three Japanese MS patients DR2,w15 haplotype (TI, SK and OK). Fourteen were originated TI, seven two OK. The PLP-reactive TCL utilized various Vbeta Jbeta gene segments, but there was significant...
Abstract Objective The aim of the present study was to investigate association magnetic resonance imaging ( MRI ) findings and social activity with cognitive function in Japanese patients multiple sclerosis MS ). Methods Brief Repeatable Battery Neuropsychological tests BRB ‐N) carried out 184 , 163 controls matched for age, sex education. cerebral, brainstem, cerebellar lesions activities were further examined. Results higher numbers cerebral on had lower scores most ‐N tests. majority...
The effects of exogenous surfactant treatment combined with postnatal ventilation on protein (SP)-A, SP-B, and SP-C steady-state mRNA levels were evaluated in preterm sheep at 120, 132, 139 days gestation. Three groups studied each gestation period: animals ventilated treated 100 mg/kg natural surfactant, not a comparison group lambs that neither nor surfactant. In unventilated lambs, SP-A measured by densitometry from Northern blots increased between 120 132 (P < 0.05). At gestation, no...
Case A 42‐year‐old Peruvian woman residing in Japan for 11 years with a family history of neurocysticercosis presented to our intensive care unit fever and intense headache. Computed tomography indicated multiple micronodular lesions the brain parenchyma, cerebral tuberculoma were considered differential diagnosis. Neurocysticercosis was initially suspected, oral praziquantel initiated. However, because high adenosine deaminase level cerebrospinal fluid positive peripheral blood interferon...
The aims of the present study were to first characterize ontogeny mRNAs encoding principal surfactant proteins SP-A, SP-B, and SP-C in rabbit lung tissues, followed by an evaluation effect exogenous administration on endogenous expression mRNA levels. Lung tissues collected from New Zealand White rabbits days 19, 21, 24, 26, 28, 30 gestation, 1 day 10 after birth, as adults. detected gestational respectively. specific levels these generally increased 28 decreased transiently life. Adult...
Abstract A multicenter, randomized, double‐blind, placebo‐controlled, efficacy and safety study of BG 00012 in participants from the Asia–Pacific region other countries with relapsing–remitting multiple sclerosis ( APEX ), including Japan, established dimethyl fumarate DMF ) preventing relapses disease progression patients MS ). Consequently, December 2016, was approved as second oral disease‐modifying drug for Japan. However, new Japanese guidelines neuromyelitis optica published 2017 did...