A5020608796- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Connexins and lens biology
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Amyotrophic Lateral Sclerosis Research
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Neurogenetic and Muscular Disorders Research
- Yersinia bacterium, plague, ectoparasites research
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Cytokine Signaling Pathways and Interactions
- Systemic Sclerosis and Related Diseases
- Sphingolipid Metabolism and Signaling
- IgG4-Related and Inflammatory Diseases
- Myasthenia Gravis and Thymoma
- Liver Disease Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Autoimmune and Inflammatory Disorders
- Parkinson's Disease Mechanisms and Treatments
Kyushu University
2016-2025
University of Chicago
2020
University of Chicago Medical Center
2018-2020
Centre Hospitalier de l’Université de Montréal
2020
McGill University
2020
Juntendo University
2014
Osaka Neurological Institute
2013
Kindai University
2011
Hiroshima University
2011
Ehime University
2011
<h3>Objectives</h3> To clarify the prevalence, frequent causes and distinct features of hypertrophic pachymeningitis (HP) according to background conditions in a nationwide survey Japan. <h3>Methods</h3> The study began with preliminary determine approximate number HP patients diagnosed from 1 January 2005 31 December 2009, was followed by questionnaire for clinical laboratory findings. defined as condition thickening cranial or spinal dura mater inflammation, evidenced MRI histology....
<h3>Objective</h3> To clarify whether genetic and common infectious backgrounds are distinct, according to anti-aquaporin 4 (AQP4) antibody status in Japanese patients with neuromyelitis optica (NMO). <h3>Methods</h3> We analysed human leucocyte antigen <i>(HLA)-DRB1</i> <i>HLA-DPB1</i> alleles, IgG antibodies against <i>Helicobacter pylori</i>, <i>Chlamydia pneumoniae</i>, varicella zoster virus Epstein–Barr nuclear (EBNA) 116 NMO, including 39 spectrum disorder (NMOSD), 145 multiple...
The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the similarly involved MS and neuromyelitis optica spectrum disorder (NMOSD). Thus, aim of this study was compare volume NMOSD.In retrospective, cross-sectional study, patients were included by convenience sampling from 4 international centers. lateral ventricles segmented fully automatically on...
Background Multiple sclerosis (MS) and neuromyelitis optica (NMO) occasionally have an extremely aggressive debilitating disease course; however, its molecular basis is unknown. This study aimed to determine a relationship between connexin (Cx) pathology aggressiveness in Asian patients with MS NMO. Methods/Principal Findings Samples included 11 autopsied cases NMO spectrum disorder (NMOSD), six MS, 20 other neurological diseases (OND). Methods of analysis immunohistochemical expression...
Background Nationwide surveys conducted in Japan over the past thirty years have revealed a four-fold increase estimated number of multiple sclerosis (MS) patients, decrease age at onset, and successive increases patients with conventional MS, which shows an involvement sites central nervous system, including cerebrum cerebellum. We aimed to clarify whether genetic infectious backgrounds correlate distinct disease phenotypes MS Japanese patients. Methodology/Principal Findings analyzed...
Background Fingolimod efficiently reduces multiple sclerosis (MS) relapse by inhibiting lymphocyte egress from lymph nodes through down-modulation of sphingosine 1-phosphate (S1P) receptors. We aimed to clarify the alterations in peripheral blood T cell subsets associated with MS on fingolimod. Methods/Principal Findings Blood samples successively collected 23 relapsing-remitting patients before and during fingolimod therapy (0.5 mg/day) for 12 months 18 healthy controls (HCs) were analysed...
There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) half patients have the NMO-Immunoglobulin G (IgG)/ anti-aquaporin-4 (AQP4) antibody. We reported that Helicobacter pylori (H. pylori) infection was significantly less common CMS than controls. To reveal immune responses H. neutrophil-activating protein (HP-NAP) Japanese MS patients, according anti-AQP4 antibody status, sera...
Non-cell-autonomous motor neuronal death is suggested in a mutant Cu/Zn superoxide dismutase 1 (mSOD1)-mediated amyotrophic lateral sclerosis (ALS) model, which glial cells play significant roles disease progression. Connexins (Cxs) form homotypic or heterotypic gap junctions (GJs) and allow direct intercellular communications among nervous tissue cells. The role of Cxs neuron has never been investigated; therefore, we aimed to evaluate alterations mSOD1-transgenic (mSOD1-Tg) mice comparison...
In multiple sclerosis plaques, oligodendroglial connexin (Cx) 47 constituting main gap junction channels with astroglial Cx43 is persistently lost. As mice Cx47 single knockout exhibit no demyelination, the roles of remain undefined. We aimed to clarify effects oligodendroglia-specific inducible conditional (icKO) on experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein peptide (MOG35-55) in PLP/CreERT;Cx47fl/fl at 14 d after tamoxifen injection. icKO...
Abstract In chronic stages of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalitis (EAE), connexin (Cx)43 gap junction channel proteins are overexpressed because astrogliosis. To elucidate the role increased Cx43, central nervous system (CNS)-permeable Cx blocker INI-0602 was therapeutically administered. C57BL6 mice with EAE initiated by MOG 35-55 received (40 mg/kg) or saline intraperitoneally every other day from days post-immunization (dpi) 17–50. Primary...
Allergic and atopic disorders have increased over the past few decades been associated with neuropsychiatric conditions, such as autism spectrum disorder asthmatic amyotrophy. Myelitis presenting neuropathic pain can occur in patients disorder; however, relationship between allergic inflammation pain, underlying mechanism, remains to be established. We studied whether affects spinal nociceptive system. found that mice asthma, dermatitis, or diathesis had widespread significantly more...
Abstract We previously reported early and extensive loss of astrocytic connexin 43 (Cx43) in acute demyelinating lesions multiple sclerosis (MS) patients. Because it is widely accepted that autoimmune T cells initiate MS lesions, we hypothesized infiltrating affect Cx43 expression astrocytes, which contributes to lesion formation. Primary mixed glial cell cultures were prepared from newborn mouse brains, microglia isolated by anti-CD11b antibody-conjugated magnetic beads. Next,...
HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype-phenotype in 528 MS 165 NMOSD cases using Japan MS/NMOSD Biobank materials. HLA-DRB1*04:05, DRB1*15:01 DPB1*03:01 correlated with susceptibility DRB1*01:01, DRB1*09:01, DRB1*13:02 DPB1*04:01 were protective against MS. HLA-DRB1*15:01 was associated increased optic neuritis cerebellar involvement worsened visual...
Abstract Objectives To assess blood exosome (Ex)‐connexin (Cx)43 (encoded by GJA1 ) and its truncated isoforms in multiple sclerosis (MS) neuromyelitis optica spectrum disorder (NMOSD), which show distinct alterations astroglial Cx43. Methods Serum Exs from 48 patients with MS (34 relapsing–remitting, 14 secondary‐progressive), 35 NMOSD, 20 other inflammatory neurologic diseases (OIND), 17 healthy controls (HC) were subjected to quantitative Western blotting for Cx43, single‐molecule array...
Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe inflammation-mediated astrocytopathy in the central nervous system. Neuropathic pain (NP) is highly prevalent among patients with NMOSD, and significantly impairs their quality of life. Alpha-calcitonin gene-related peptide (α-CGRP) a neuropeptide related to neuroinflammation peripheral nerves; however, involvement α-CGRP NMOSD pathophysiology remains unexplored. Here, we measured serum levels 33 36 healthy controls...
Background and objective: The objective of this study is to clarify clinical, immunological, neuroimaging features in anti-aquaporin-4 (AQP4) antibody-positive antibody-negative Sjögren’s syndrome (SS) patients with central nervous system (CNS) involvement. Methods: Medical records MRI scans were retrospectively analyzed 22 consecutive SS CNS manifestations. Results: Seven (31.8%) positive for anti-AQP4 antibodies. frequency visual impairment was higher than (71.4% vs. 0.0%, p = 0.0008)....
Abnormal intrathecal synthesis of IgG, reflected by cerebrospinal fluid (CSF) oligoclonal IgG bands (OBs) and increased index, is much less frequently observed in Japanese multiple sclerosis (MS) cohorts compared with Western cohorts. We aimed to clarify whether genetic common infectious backgrounds influence CSF abnormality MS patients.
Background: To clarify the clinical relevance of anti-aquaporin-4 (anti-AQP4) antibody titers and immunoglobulin (IgG) subclass. Methods: Using a bridging enzyme-linked immunosorbent assay (ELISA), flow cytometric (FCMA) an immunofluorescence (IFA) for anti-AQP4 antibodies, sera from 142 patients with multiple sclerosis (MS) as defined by McDonald criteria (2005), 29 neuromyelitis optica (NMO) who fulfilled 1999 criteria, 19 recurrent and/or longitudinally extensive myelitis (RM/LM), 86...