A5102997157- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Laser-Matter Interactions and Applications
- Synthetic Aperture Radar (SAR) Applications and Techniques
- High-pressure geophysics and materials
- Arctic and Antarctic ice dynamics
- Advanced SAR Imaging Techniques
- Plasma Diagnostics and Applications
- Advanced X-ray Imaging Techniques
- Laser Design and Applications
- Ocean Waves and Remote Sensing
- Risk and Safety Analysis
- Soil Moisture and Remote Sensing
- Cryospheric studies and observations
- Electrohydrodynamics and Fluid Dynamics
- Multiple Sclerosis Research Studies
- Oceanographic and Atmospheric Processes
- Genetically Modified Organisms Research
- Laser Material Processing Techniques
- Helicobacter pylori-related gastroenterology studies
- Nuclear Physics and Applications
- Climate change and permafrost
- Magnetic confinement fusion research
- Astro and Planetary Science
- CRISPR and Genetic Engineering
Teijin (Japan)
2025
Fukuoka University
2025
Osaka University
2013-2023
Red Cross Hospital
2020-2023
National Institute of Information and Communications Technology
2011-2023
Utsunomiya University
2008-2023
Mitsubishi Chemical (Germany)
2023
Sapporo Medical University
2023
University of Shizuoka
2015-2021
Asahi Kasei (Japan)
2005-2021
We demonstrate the highest intensity - 300 TW laser by developing booster amplifying stage to 50-TW-Ti:sapphire (HERCULES). To our knowledge this is first multi-100TW-scale at 0.1 Hz repetition rate.
Abstract New quantitation methods based on a real-time polymerase chain reaction (PCR) technique were developed for 5 lines of genetically modified (GM) maize, including MON810, Event176, Bt11, T25, and GA21, GM soy, Roundup Ready. Oligonucleotide DNA, specific primers fluorescent dye, labeled probes, designed PCRs. Two plasmids constructed as reference molecules (RMs) the detection maize soy. The contain DNA sequences region found in each line, universal used various lines, such cauliflower...
We consider the effect of laser beam shaping on proton acceleration in interaction a tightly focused pulse with ultrathin double-layer solid targets regime directed Coulomb explosion. In this regime, heavy ions front layer are forced by to expand predominantly direction propagation, forming moving longitudinal charge separation electric field, thus increasing effectiveness second-layer protons. The utilization shaping, namely, use flat-top beams, leads more efficient due increase field.
We show that x-rays from a recently demonstrated table top source of bright, ultrafast, coherent synchrotron radiation [Kneip et al., Nat. Phys. 6, 980 (2010)] can be applied to phase contrast imaging biological specimens. Our scheme is based on focusing high power short pulse laser in tenuous gas jet, setting up plasma wakefield accelerator accelerates and wiggles electrons analogously conventional synchrotron, but the centimeter rather than tens meter scale. use record absorption images...
Seven lines of genetically modified (GM) maize have been authorized in Japan as foods and feeds imported from the USA. We improved a multiplex PCR method described previous report order to distinguish five GM maize. Genomic DNA was extracted with silica spin column kit, which could reduce experimental time improve safety laboratory potentially environment. sequenced recombinant (r-DNA) introduced into maize, re-designed new primer pairs increase specificity by PCR. A pair for intrinsic zein...
Proton acceleration by high-intensity laser pulses from ultrathin foils for hadron therapy is discussed. With the improvement of intensity contrast ratio to 10(-1) achieved on Hercules at University Michigan, it became possible attain laser-solid interactions intensities up 10(22) W/cm2 that allows an efficient regime laser-driven ion submicron foils. Particle-in-cell (PIC) computer simulations proton in directed Coulomb explosion double-layer (heavy ions/light ions) different thicknesses...
The propagation of ultra intense laser pulses through matter is connected with the generation strong moving magnetic fields in channel as well formation a thin ion filament along axis channel. Upon exiting plasma field displaces electrons at back target, generating quasistatic electric that accelerates and collimates ions from filament. Two-dimensional Particle-in-Cell simulations show 1 PW pulse tightly focused on near-critical density target able to accelerate protons up an energy 1.3 GeV....
Background Multiple sclerosis (MS) and neuromyelitis optica (NMO) occasionally have an extremely aggressive debilitating disease course; however, its molecular basis is unknown. This study aimed to determine a relationship between connexin (Cx) pathology aggressiveness in Asian patients with MS NMO. Methods/Principal Findings Samples included 11 autopsied cases NMO spectrum disorder (NMOSD), six MS, 20 other neurological diseases (OND). Methods of analysis immunohistochemical expression...
Abstract Novel analytical methods based on real-time quantitative polymerase chain reactions by use of new reference molecules were validated in interlaboratory studies for the quantitation genetically modified (GM) maize and soy. More than 13 laboratories from Japan, Korea, United States participated studies. The included 2 separate stages: (1) measurement tests coefficient values, ratio recombinant DNA (r-DNA) sequence, endogenous sequence seeds GM soy; (2) blind with 6 pairs soy samples,...
Diabetic retinopathy is characterized by increased vascular permeability, ischemia, and neovascularization. Ischemia in the retina can induce neovascularization via induction of endothelial growth factor (VEGF) expression transcription hypoxia-inducible factor-1 (1). Hypoxia also main stimulus for erythropoietin (EPO) gene expression. It has been reported that EPO may have not only erythropoietic (2) but neuroprotective (3) angiogenic (4) effects. expressed at a number sites including...
Two-phase friction pressure drop and heat transfer coefficients in a once-through steam generator with helically coiled tubes were investigated the model test rig of an integrated type marine water reactor. As dimensions thermal-fluid conditions are almost same as those real reactors, data applicable directly to reactor design obtained. drop, modified Kozeki's prediction which is based on experimental by Kozeki for tubes, agreed best data. Modified Martinelli-Nelson's multiplier using Ito's...
Abstract Purpose: Highly invasive and metastatic cancer cells, such as adenocarcinoma of the lung form irregular protrusions by assembling a branched network actin filaments. In mammalian actin-related protein 2 3 (Arp2/3) complex initiates assembly to lamellipodial binding Wiskott-Aldrich syndrome (WASP)/WASP family verproline-homologous (WAVE2). this study, colocalization Arp2 WAVE2 in was investigated elucidate its prognostic value. Experimental Design: Immunohistochemical staining done...
There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) half patients have the NMO-Immunoglobulin G (IgG)/ anti-aquaporin-4 (AQP4) antibody. We reported that Helicobacter pylori (H. pylori) infection was significantly less common CMS than controls. To reveal immune responses H. neutrophil-activating protein (HP-NAP) Japanese MS patients, according anti-AQP4 antibody status, sera...
The understanding of fracture phenomena a material at extremely high strain rates is key issue for wide variety scientific research ranging from applied science and technological developments to fundamental such as laser-matter interaction geology. Despite its interest, study relies on fine multiscale description, in between the atomic scale macroscopic processes, so far only achievable by large-scale simulations. Direct ultrafast real-time monitoring dynamic (spallation) lattice with...
OBJECTIVE To determine whether hepatocyte growth factor (HGF) is elevated in the vitreous fluid of patients with proliferative diabetic retinopathy (PDR). RESEARCH DESIGN AND METHODS Vitreous samples were obtained at time vitreoretinal surgery from 73 eyes PDR and 17 nondiabetic (control subjects) who had macular hole, rhegmatogenous retinal detachment, or epiretinal membrane (9, 4, 4 eyes, respectively) but no associated vitreoretinopathy. Stages classified as active quiescent....
Polymerase Chain Reaction (PCR) techniques are increasingly used for the detection of genetically modified (GM) crops in foods. In this paper, recombinant DNAs introduced into seven lines GM maize, such as Event 176, Bt11, T25, MON810, GA21, DLL25, and MON802, sequenced. On basis obtained sequence, 14 primer pairs segments, promoter, terminator regions, construct genes, were designed. To confirm specificities designed pairs, PCR was performed on genomic extracted from non-GM soy, other...
The relative complex dielectric permittivity, ε*=ε′−iε″, of ice has been measured in the frequency range 5–39 GHz and temperature 190–265 K. cavity resonator method at 5 10 open 33 39 were used to determine low loss ice. real part permittivity ε′ was independent frequency. dependence observed is discussed terms contributions from anharmonic effects infrared polarizability. ε″ obtained bridges gap previous results between 200 258 We discuss effect absorption band on ε″. variation with...