A5033313879- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Medical Imaging and Analysis
- Polyomavirus and related diseases
- Ultrasound Imaging and Elastography
- Peripheral Neuropathies and Disorders
- Fetal and Pediatric Neurological Disorders
- Digital Imaging for Blood Diseases
- Systemic Lupus Erythematosus Research
- Spinal Dysraphism and Malformations
- Radiopharmaceutical Chemistry and Applications
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Cerebral Venous Sinus Thrombosis
- Amyotrophic Lateral Sclerosis Research
- Medical Image Segmentation Techniques
- Cervical and Thoracic Myelopathy
- Biotin and Related Studies
- Cerebrospinal fluid and hydrocephalus
- Brain Tumor Detection and Classification
- Glaucoma and retinal disorders
- Brain Metastases and Treatment
- Neural and Behavioral Psychology Studies
- Electron Spin Resonance Studies
University Hospital of Basel
2016-2025
University of Basel
2018-2025
National Institute of Neurological Disorders and Stroke
2021-2024
National Institutes of Health
2021-2024
Hospital Base
2021
University of California, Irvine
2019
Université de Sherbrooke
2019
Douglas Mental Health University Institute
2019
Helios Kliniken
2018-2019
Roche (Switzerland)
2019
Neuro-axonal injury is a key factor in the development of permanent disability multiple sclerosis. Neurofilament light chain peripheral blood has recently emerged as biofluid marker reflecting neuro-axonal damage this disease. We aimed at comparing serum neurofilament levels sclerosis and healthy controls, to determine their association with measures disease activity ability predict future clinical worsening well brain spinal cord volume loss. was measured by single molecule array assay 2183...
Spinal cord segmentation is clinically relevant and notably used to compute spinal cross-sectional area (CSA) for the diagnosis monitoring of compression or neurodegenerative diseases such as multiple sclerosis. While several semi automatic methods exist, one key limitation remains: depends on MRI contrast, resulting in different CSA across contrasts. This partly due varying appearance boundary between cerebrospinal fluid that sequence acquisition parameters. contrast-sensitive adds...
The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the similarly involved MS and neuromyelitis optica spectrum disorder (NMOSD). Thus, aim of this study was compare volume NMOSD.In retrospective, cross-sectional study, patients were included by convenience sampling from 4 international centers. lateral ventricles segmented fully automatically on...
Progression independent of relapse activity (PIRA) is a crucial determinant overall disability accumulation in multiple sclerosis (MS). Accelerated brain atrophy has been shown patients experiencing PIRA. In this study, we assessed the relation between PIRA and neurodegenerative processes reflected by (1) longitudinal spinal cord (2) paramagnetic rim lesions (PRLs). Besides, same relationship was investigated progressive MS (PMS). Last, explored value cross-sectional volumetric measurements...
Cross-sectional studies have shown that spinal cord volume (SCV) loss is related to disease severity in multiple sclerosis (MS). However, long-term data are lacking. Our aim was evaluate SCV as a biomarker of progression comparison other MRI measurements large cohort patients with relapse-onset MS 6-year follow-up.The upper cervical SCV, the total brain volume, and T2 lesion were measured annually 231 (180 relapsing-remitting [RRMS] 51 secondary progressive [SPMS]) over 6 years on...
Myelin and iron play essential roles in remyelination processes of multiple sclerosis (MS) lesions. χ-separation, a novel biophysical model applied to multiecho T2*-data T2-data, estimates the contribution myelin obtained susceptibility signal. We used this method investigate levels lesion nonlesion brain areas patients with MS healthy individuals.
Little is known on longer term changes of spinal cord volume (SCV) in primary progressive multiple sclerosis (PPMS).Longitudinal evaluation SCV loss PPMS and its correlation to clinical outcomes, compared relapse-onset (MS) subtypes.A total 60 MS age-, sex- disease duration-matched patients (12 PPMS, each 24 relapsing-remitting (RRMS) secondary (SPMS)) were analysed annually over 6 years follow-up. The upper cervical was measured 3D T1-weighted magnetization-prepared rapid gradient-echo...
To study if the thalamic lateral geniculate nucleus (LGN) is affected in multiple sclerosis (MS) due to anterograde degeneration from optic neuritis (ON) or retrograde radiation (OR) pathology, and this relevant for visual function.In cross-sectional study, LGN volume of 34 patients with relapsing-remitting MS 33 matched healthy controls (HC) was assessed on MRI using atlas-based automated segmentation (MAGeT). ON history, thickness ganglion cell-inner plexiform layer (GC-IPL), OR lesion...
Abstract Objective To determine the levels of brain‐derived neurotrophic factor (BDNF) in serum patients suffering from multiple sclerosis (MS) to evaluate potential BDNF as a biomarker for MS. Methods Using recently validated enzyme‐linked immunoassay (ELISA) we measured with MS (pwMS), diagnosed according 2001 McDonald criteria and aged between 18 70 years, participating long‐term cohort study annual clinical visits, including blood sampling, neuropsychological testing, brain magnetic...
Purpose: To investigate, for the first time, efficacy of Fluid and White Matter Suppression (FLAWS) MRI sequence in improving Deep Learning (DL)-based detection segmentation cortical lesions Multiple Sclerosis (MS) patients even, with applicability to clinical settings where only standard T1-weighted images are available. Materials Methods: In this retrospective multi-site study, we analyzed 204 MS using DL models developed FLAWS Magnetization Prepared 2 Rapid Acquisition Gradient Echoes...
Abstract In multiple sclerosis (MS), cortical atrophy is correlated with clinical and neuropsychological measures. We aimed to examine the differences in temporospatial evolution of thickness (CTh) between MS‐subtypes study association CTh T2‐weighted white matter lesions (T2LV) progression. Two hundred forty‐three MS patients (180 relapsing–remitting [RRMS], 51 secondary‐progressive [SPMS], 12 primary‐progressive [PPMS]) underwent annual (incl. expanded disability status scale [EDSS])...
Ultra-low field (ULF) magnetic resonance imaging (MRI) holds the potential to make MRI more accessible, given its cost-effectiveness, reduced power requirements, and portability. However, signal-to-noise ratio (SNR) drops with strength, necessitating lower resolution longer scan times. This study introduces a novel Fourier-based Super Resolution (FouSR) approach, designed enhance of ULF images minimal increase in total time. FouSR combines spatial frequencies from two orthogonal anisotropic...
Cerebellar symptoms in multiple sclerosis (MS) are well described; however, the exact contribution of cerebellar damage to MS disability has not been fully explored. Longer-term observational periods necessary better understand dynamics pathological changes within cerebellum and their clinical consequences. lobe single lobule volumes were automatically segmented on 664 3D-T1-weighted MPRAGE scans (acquired at a 1.5 T scanner) 163 patients (111 women; mean age: 47.1 years; 125...
Abstract Background and purpose In an era of individualized multiple sclerosis (MS) patient management, biomarkers for accurate prediction future clinical outcomes are needed. We aimed to evaluate the potential short‐term magnetic resonance imaging (MRI) atrophy measures serum neurofilament light chain (sNfL) as predictors dynamics disability accumulation in relapse‐onset MS. Methods Brain gray white matter, thalamic, striatal, pallidal cervical spinal cord volumes, lesion load were measured...
Cortical lesions are common in multiple sclerosis (MS), but their visualization is challenging on conventional magnetic resonance imaging. The uniform image derived from magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE uni ) detects cortical with a similar rate as the criterion standard sequence, double inversion recovery. Fluid and white matter suppression (FLAWS) provides reconstructed contrasts acquired during single acquisition. These include FLAWS minimum (FLAWS min...
There is evidence that multiple sclerosis (MS) pathology leads to distinct patterns of volume loss over time (VLOT) in different central nervous system (CNS) structures. We aimed use such identify patient subgroups. MS patients all classical disease phenotypes underwent annual clinical, blood, and MRI examinations 6 years. Spinal, striatal, pallidal, thalamic, cortical, white matter, T2-weighted lesion volumes as well serum neurofilament light chain (sNfL) were quantified. CNS VLOT...
<h3>BACKGROUND AND PURPOSE:</h3> Currently, accurate and reproducible spinal cord GM segmentation remains challenging a noninvasive broadly accepted reference standard for measurements is still matter of ongoing discussion. Our aim was to assess the reproducibility accuracy cervical WM cross-sectional area using averaged magnetization inversion recovery acquisitions images fully-automatic postprocessing algorithm. <h3>MATERIALS METHODS:</h3> The 24 healthy subjects (14 women; mean age, 40 ±...
Background: Spinal cord (SC) gray and white matter pathology plays a central role in multiple sclerosis (MS). Objective: We aimed to investigate the extent, pattern, clinical relevance of SC atrophy vivo. Methods: 39 relapsing–remitting patients (RRMS), 40 progressive MS (PMS), 24 healthy controls (HC) were imaged at 3T using averaged magnetization inversion recovery acquisitions sequence. Total lesional cervical matter, posterior (SCPH) anterior horn (SCAH) areas automatically quantified....
Fully automatic quantification methods of spinal cord compartments are needed to study pathologic changes the GM and WM in MS vivo. We propose a novel method for compartment segmentation (SCORE) patients with MS.
Although cervical spinal cord (cSC) area is an established biomarker in MS, there currently a lack of longitudinal assessments cSC gray and white matter areas.We conducted explorative analysis changes areas MS patients.65 patients (33 relapsing-remitting; 20 secondary progressive 12 primary progressive) healthy controls (HC) received clinical upper MRI over 1.10±0.28 years. compartments were quantified on using the novel averaged magnetization inversion recovery acquisitions sequence...
To explore associations of the main component (P100) visual evoked potentials (VEP) to pre- and postchiasmatic damage in multiple sclerosis (MS). 31 patients (median EDSS: 2.5), 13 with previous optic neuritis (ON), healthy controls had VEP, optical coherence tomography magnetic resonance imaging. We tested P100-latency peripapillary retinal nerve fiber layer (pRNFL), ganglion cell/inner plexiform layers (GCIPL), lateral geniculate nucleus volume (LGN), white matter lesions radiations...