A5088542167- Multiple Sclerosis Research Studies
- Fetal and Pediatric Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- Glioma Diagnosis and Treatment
- Tracheal and airway disorders
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Polyomavirus and related diseases
- Spine and Intervertebral Disc Pathology
- Autoimmune Neurological Disorders and Treatments
- COVID-19 and Mental Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Infectious Diseases and Tuberculosis
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Child Development and Digital Technology
- Intracranial Aneurysms: Treatment and Complications
- RNA regulation and disease
- Dermatologic Treatments and Research
- Meningioma and schwannoma management
University Hospital of Basel
2011-2024
University of Basel
2021-2024
University of Konstanz
2022
University College London
2018
OLVG
2018
<h3>Importance</h3> The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood. <h3>Objective</h3> To determine whether disability progression independent of relapse activity (PIRA) patients with RMS is associated accelerated tissue loss. <h3>Design, Setting, Participants</h3> In this observational, longitudinal cohort study median (IQR) follow-up 3.2 years (2.0-4.9), data were acquired from January 2012 to September 2019 a...
Progression independent of relapse activity (PIRA) is a crucial determinant overall disability accumulation in multiple sclerosis (MS). Accelerated brain atrophy has been shown patients experiencing PIRA. In this study, we assessed the relation between PIRA and neurodegenerative processes reflected by (1) longitudinal spinal cord (2) paramagnetic rim lesions (PRLs). Besides, same relationship was investigated progressive MS (PMS). Last, explored value cross-sectional volumetric measurements...
Background Growing evidence suggests that the central nervous system is affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since infected patients suffer from and long-term neurological sequelae. Nevertheless, it currently unknown whether virus affects brain cortex. The purpose of this study was to assess cortical gray matter volume, thickness, surface area in a group SARS-CoV-2 with symptoms compared healthy control subjects. Additionally, we analyzed features...
<h3>Objective</h3> In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer higher lesion detection than 1.5T, but it remains unclear whether this affects fulfilment diagnostic criteria for multiple sclerosis (MS). <h3>Methods</h3> We recruited 66 CIS within 6 months from symptom onset and 26 healthy controls in MS centers. All participants underwent 1.5T brain spinal cord at baseline according to local optimized protocols MAGNIMS guidelines....
Objective We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting inflammatory activity chronic worsening. Methods compared cerebrospinal fluid analysis, clinical magnetic resonance imaging data, serum neurofilament light chain (sNfL) levels at baseline follow‐up 530 patients MS. Patients were categorized by the presence oligoclonal bands (OCGB) IgM (intrathecal fraction [IF]: IF )....
Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose this study was investigate how MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients 10 healthy controls from our ongoing prospective multicentre cohort. All subjects...
Background Detecting new and enlarged lesions in multiple sclerosis (MS) patients is needed to determine their disease activity. LeMan‐PV a software embedded the scanner reconstruction system of one vendor, which automatically assesses white matter (NELs) follow‐up MS patients; however, multicenter validation studies are lacking. Purpose To assess accuracy for longitudinal detection NEL white‐matter clinical setting. Study Type Retrospective, longitudinal. Subjects A total 206 with...
Intrathecal Immunoglobulin M synthesis (IgMIntrathecal Fraction (IF)+ ) and spinal MRI lesions are both strong independent predictors of higher disease activity severity in multiple sclerosis (MS). We investigated whether IgMIF+ is associated with cord manifestation neuroaxonal damage early MS.In 122 patients a first demyelinating event associations between (1) versus (vs) non-spinal clinical syndrome (2) vs cerebral T2-weighted (T2w) (3) contrast-enhancing (CE) lesion counts IgGIF+ (vs...
Assessment of multiple sclerosis (MS) lesions on magnetic resonance imaging (MRI) is tedious, time-consuming, and error-prone. We evaluate whether assessment new, expanding, contrast-enhancing MS can be done more time-efficiently by radiologists with assistance artificial intelligence (AI).
Motivation: Detection of contrast-enhanced lesions (CELs) is fundamental for the diagnosis and monitoring Multiple Sclerosis (MS) patients. This task time-consuming variable in clinical setting. However, only a few studies reported automatic approaches. Goal(s): To develop deep-learning tool to automatically detect segment CELs MRI scans from MS Approach: We implemented UNet-based network with an adapted sampling strategy overcome scarcity CELs. considered data imbalance weight training loss...
Zusammenfassung. Hintergrund: Positive Fachkraft-Kind-Interaktionen in der Kita werden als vorteilhaft für die Entwicklung von Kindern und deren schulrelevanten Fähigkeiten angesehen. Die gemessenen Zusammenhänge sind jedoch größtenteils schwach. Möglicherweise wirkt sich Interaktionsqualität stärker auf Kinder mit niedriger Emotionsregulation aus, da diese Ko-regulation durch Fachkräfte angewiesen sein könnten. vorliegende Studie untersucht den Zusammenhang Lern- Sozialverhalten eine...
Abstract Increasing evidence shows that the brain is a target of SARS-CoV-2. However, consequences virus on cortical regions hospitalized patients are currently unknown. The purpose this study was to assess gray matter volume (GMV), thickness (Th), and surface area (SA) characteristics in SARS-CoV-2 with wide range neurological symptoms their association clinical indicators inflammatory processes. A total 33 were selected from prospective, multicenter, cross-sectional during ongoing pandemic...
Measures of cerebral small vessel disease (cSVD), such as white matter hyperintensities (WMH) and microbleeds (CMB), are associated with an unfavorable clinical course in stroke patients on oral anticoagulation (OAC) for atrial fibrillation (AF). Here, we investigated whether similar findings can be observed global cortical atrophy (GCA).Registry-based prospective observational study 320 treated OAC following AF stroke. Patients underwent magnetic resonance imaging (MRI) allowing assessment...
In this article the general clinical aspects, imaging indications and dif ferent injury mechanisms of traumatic brain (TBI) are reviewed.In addition, different modalities strategies presented, including more specific features various injuries.Computed tomography (CT) is modality choice in acute phase ow ing to its wide availability short scanning time, as well high sensitivity for detection fractures bleeding.Although magnetic resonance (MRI) superior CT many other pects, it plays no role...
Although there is a large variability in the neural organization of language function between individuals, an ongoing debate about functional imaging as standard procedure preoperative setting brain tumors. Brain mapping centers differs from individual to multilingual patients and changes its architecture may occur result neuroplasticity induced by mass lesion. This article discusses role setting.Obwohl die neuronale Organisation der Sprachfunktion von Mensch zu eine hohe inter-individuelle...
A quantitative imaging study is critical to detect cortical brain macrostructural alterations associated with an inflammatory response in hospitalized SARS-CoV-2 patients. Using automated processing of the 3D high-resolution T1-weighted anatomical images, we found a decrease gray matter volume and thickness, but not surface area related increased levels CSF protein, blood/albumin ratio, EN-RAGE. The localization these regions may be vivo hallmarks virus effect on cortex due hyperinflammatory...
Objective . The purpose of this study was to determine the frequency thromboembolic events associated with angioplasty and stenting carotid artery special regard extra- or intracranial localization stenosis. Methods Twenty patients symptomatic extracranial internal stenosis were treated and/or angioplasty. In 4 technically not feasible (all in group stenosis). All underwent diffusion-weighted imaging (DWI) neurological examination within 48 hours before after procedure detect periprocedural...