A5108752278- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Food Allergy and Anaphylaxis Research
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Rheumatoid Arthritis Research and Therapies
- Complement system in diseases
- Asthma and respiratory diseases
- Systemic Sclerosis and Related Diseases
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Multiple Sclerosis Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Platelet Disorders and Treatments
- Pediatric health and respiratory diseases
- HER2/EGFR in Cancer Research
- Peripheral Neuropathies and Disorders
University Hospital of Basel
2015-2024
University of Basel
2009-2024
Azienda Ospedaliera di Padova
2022
University of Padua
2022
Walter de Gruyter (Germany)
2022
Zentrum für Labormedizin
2012-2021
Hospital Base
2011-2017
Kantonsspital Aarau
2003-2015
Kantonsspital Münsterlingen
2015
Kantonsspital St. Gallen
2015
Background: In a previous controlled study, we demonstrated that preseasonal grass pollen immunotherapy for 3 years was effective in children. Moreover, significant clinical benefit could still be observed 6 after discontinuation of specific (SIT). the current examined same group patients again to investigate whether there is prolonged 12 SIT stopped. Methods: Twenty‐two with (from 1989 through 1991) or standardized seasonal pharmacotherapy only were prospectively followed during season...
Besides their phagocytic effector functions, myeloid cells have an essential role as accessory in the induction of optimal humoral immune responses by presenting captured antigens and activating lymphocytes. Antigen presentation human monocytes was recently found to be enhanced vitro through high-affinity Fc receptor for IgG (Fc gamma RI; CD64), which is exclusively present on cells. To evaluate a comparable RI antigen vivo, we generated transgenic mice. Under control its endogenous...
A dysregulated immune response with hyperinflammation is observed in patients severe coronavirus disease 2019 (COVID-19). The aim of the present study was to assess safety and potential benefits human recombinant C1 esterase inhibitor (conestat alfa), a complement, contact activation kallikrein-kinin system regulator, COVID-19. Patients evidence progressive after 24 h including an oxygen saturation <93% at rest ambient air were included University Hospital Basel, Switzerland April 2020....
Histopathologic studies have identified immunoglobulin (Ig) deposition and complement activation as contributors of CNS tissue damage in multiple sclerosis (MS). Intrathecal IgM synthesis is associated with higher MS disease activity severity, the strongest complement-activating immunoglobulin. In this study, we investigated whether components (CCs) products (CAPs) are increased persons MS, especially those an intrathecal synthesis, they severity progression.
Studies in IL-12-deficient mice established the necessity for IL-12 to generate a Th1 cytokine response that is often required elimination of intracellular pathogens. In this study, we demonstrate with targeted disruption IL-12p40 and/or p35 gene effectively control liver damage induced by mouse hepatitis virus (MHV) infection, similar wild-type animals. contrast, MHV-infected IFN-gamma receptor-deficient (IFN-gammaR[-/-]) showed an increased susceptibility coronaviral hepatitis....
Stimulation of the immune system by targeting PD-1/PD-L1 pathway can result in activation anti-tumor immunity. Besides its clinical benefit checkpoint therapy leads to significant immune-related adverse events (irAEs). Some rare irAEs are not well described yet but critical patient management.Here, we describe a case autoimmune cerebral vasculitis/encephalitis after PD-1 inhibitor treatment for metastatic adenocarcinoma lung. Upon blockade, developed lesions, while having disease...
Abstract Objectives Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There many variables influencing IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on testing that offer novel features adopted some clinical laboratories include automated...
Abstract Previously, we have demonstrated that phagocytosis of IgG1-coated particles by macrophages in vitro is impaired deletion FcγRIII mice, suggesting IgG1 may interact preferentially with FcγRIII. In the present study, biologic relevance this observation was addressed triggering various effector functions immune system FcγRIII−/− using panels mAbs different IgG subclasses. Both binding and sheep or human erythrocytes were strongly impaired, indicating ingestion complexed...
Purpose Rituximab maintenance therapy has been shown to improve progression-free survival in patients with follicular lymphoma; however, the optimal duration of treatment remains unknown. Patients and Methods Two hundred seventy untreated, relapsed, stable, or chemotherapy-resistant lymphoma were treated four doses rituximab monotherapy weekly intervals (375 mg/m 2 ). achieving at least a partial response randomly assigned receive one infusion every months, either on short-term schedule...
In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was determine the value anti-C1q as follow-up marker disease activity and renal involvement in patients systemic erythematosus (SLE). Fifty-two SLE a minimum three measurements during analyzed. Anti-C1q levels correlated global scores. subgroup analyses, without did not show significant correlation between activity....
Background Rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) are important biomarkers for diagnosis of rheumatoid arthritis (RA). However, there is poor harmonisation RF ACPA assays. The aim this study was to refine interpretation across commercial Materials methods Six total isotype-non-specific assays, 3 IgM isotype-specific assays 9 immunoglobulin G 13 different companies were evaluated using 398 diagnostic samples from patients with RA 1073 disease controls....
We identified a novel human circovirus in an immunocompromised 66-year-old woman with sudden onset of self-limiting hepatitis. detected 1 (HCirV-1) transcripts hepatocytes and the HCirV-1 genome long-term patient's blood, stool, urine. is emerging pathogen that persists susceptible patients.
Levels of activated complement proteins in the CSF are increased people with multiple sclerosis (MS) and associated clinical disease severity. In this study, we determined whether activation profiles track quantitative MRI metrics liquid biomarkers indicative activity progression.
Severe hypersensitivity reactions to red meat with delay of several hours in patients IgE alpha-gal (galactose-alpha-1,3-galactose) have been reported. The diagnosis allergy is difficult, because the limited sensitivity skin prick tests and specific extracts. These circumstances explained by delayed expression due digestive processes. Because low meat, we studied possibility perform cetuximab, which carries epitope. Skin intradermal cetuximab were clearly positive 2 patients. As a further...