A5039513081- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Mycobacterium research and diagnosis
- Lymphoma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Animal Virus Infections Studies
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Whipple's Disease and Interleukins
- Cytokine Signaling Pathways and Interactions
- Genomics and Rare Diseases
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Microbial infections and disease research
- SARS-CoV-2 and COVID-19 Research
- Protein Tyrosine Phosphatases
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Hematological disorders and diagnostics
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
University Hospital of Basel
2019-2024
Hospital Base
2024
University of Basel
2019-2023
We identified a novel human circovirus in an immunocompromised 66-year-old woman with sudden onset of self-limiting hepatitis. detected 1 (HCirV-1) transcripts hepatocytes and the HCirV-1 genome long-term patient's blood, stool, urine. is emerging pathogen that persists susceptible patients.
Abstract The protein tyrosine phosphatase SHP2 activates oncogenic pathways downstream of most receptor kinases (RTK) and has been implicated in various cancer types, including the highly aggressive subtype triple-negative breast (TNBC). Although allosteric inhibitors have developed are currently being evaluated clinical trials, neither mechanisms resistance to these agents, nor means circumvent such clearly defined. PI3K signaling pathway is also hyperactivated contributes anticancer...
Extranodal marginal zone lymphomas (eMZL) can occur in any organ and site of the body. Recent research has shown that they differ from to terms their mutational profile. In this study, we investigated a cohort primary breast (PBMZL) get better insight into morphologic molecular A 15 cases (14 female 1 male) was characterized by immunohistochemistry (IHC) for 19 markers, fluorescence situ hybridization (FISH), high throughput sequencing (HTS) using lymphoma panel comprising 172 genes....
Metastasis is the leading cause of cancer-related deaths breast cancer patients. Some cells in a tumour go through successive steps, referred to as metastatic cascade, and give rise metastases at distant site. We know that plasticity heterogeneity play critical roles metastasis but precise underlying molecular mechanisms remain elusive. Here we aimed identify during colonization, one most important yet poorly understood steps cascade. performed single-cell RNA-Seq (scRNA-Seq) on tumours...
Identification of bacterial pathogens in formalin fixed, paraffin embedded (FFPE) tissue samples is limited to targeted and resource-intensive methods such as sequential PCR analyses. To enable unbiased screening for FFPE samples, we established a whole genome sequencing (WGS) method that combines shotgun metagenomics taxonomic identification after subtraction human genomic reads. validate the assay, analyzed more than 100 known composition well lung autopsy tissues with without histological...
<title>Abstract</title> Background Marginal zone lymphomas of mucosa-associated lymphatic tissues (MZL MALT) are a group indolent B-cell neoplasms, which thought to arise from chronic antigenic stimulation B-cells either due underlying infection or autoimmune disease. Little is known about potential causative pathogens in pulmonary MZL (PMZL), although some data suggests role <italic>Achromobacter</italic> (<italic>A.</italic>) <italic>xylosoxidans</italic>. Methods An index case...
Abstract Somatic variant testing through next-generation sequencing (NGS) is well integrated into Swiss molecular pathology laboratories and has become a standard diagnostic method for numerous indications in cancer patient care. Currently, there wide variation reporting practices within our country, as patients move between different hospitals, it increasingly necessary to standardize NGS reports ease their reinterpretation. Additionally, many stakeholders—oncologists, hematologists,...
Aims Severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) infection broadly affects organ homeostasis, including the haematopoietic system. Autopsy studies are a crucial tool for investigation of organ‐specific pathologies. Here we perform an in‐depth analysis impact severe disease 2019 (COVID‐19) on bone marrow haematopoiesis in correlation with clinical and laboratory parameters. Methods results Twenty‐eight autopsy cases five controls from two academic centres were included...
Abstract Metastasis is the leading cause of cancer-related deaths breast cancer patients. Some cells in a tumour go through successive steps, referred to as metastatic cascade, and give rise metastases at distant site. We know that plasticity heterogeneity play critical roles metastasis but precise underlying molecular mechanisms remain elusive. Here we aimed identify during colonization, one most important yet poorly understood steps cascade. performed single-cell RNA-Seq (scRNA-Seq) on...