Simone Muenst
A5052275469- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Hepatocellular Carcinoma Treatment and Prognosis
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Immune cells in cancer
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
- Gallbladder and Bile Duct Disorders
- Lymphoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Cell Image Analysis Techniques
- Wnt/β-catenin signaling in development and cancer
- CRISPR and Genetic Engineering
University Hospital of Basel
2016-2025
University of Basel
2014-2024
Breast Center
2015-2021
University of Bologna
2018
University of Nottingham
2018
Thomas Jefferson University Hospital
2018
University Hospital of Zurich
2018
Memorial Sloan Kettering Cancer Center
2018
Ospedale Bellaria
2018
Institute of Molecular and Clinical Ophthalmology Basel
2015
Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial-myoepithelial differentiation, whose genetic underpinning largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepitheliomas display PIK3CA or AKT1 activating mutations, ER-negative harbor highly recurrent codon Q61 HRAS hotspot which co-occur with PIK3R1 mutations. In two- three-dimensional cell culture models,...
Epithelial cell adhesion molecule (EpCAM) is frequently expressed in breast cancer, and its expression has been associated with poor prognosis. Breast cancer can be subdivided into intrinsic subtypes, differing prognosis response to therapy. To investigate the association between EpCAM subtypes of we performed immunohistochemical studies on a tissue microarray encompassing total 1365 cancers detailed clinicopathological annotation outcomes data. We observed 660 out (48%) cases. varied...
Complete lymph node removal through conventional axillary dissection (ALND) has been standard treatment for breast cancer patients almost a century. In the 1990s, however, and in parallel with advent of sentinel (SLN) procedure, ALND came under increasing scrutiny due to its association significant patient morbidity. Several studies have since provided evidence suggest omission ALND, often favor radiation, selected clinically node-negative, SLN-positive patients, thus supporting current...
Aims : Programmed death-1 (PD-1) is expressed by germinal center-associated helper T-cells and acts as a negative regulator of the immune system. PD-1 encountered on tumor cells angioimmunoblastic T-cell lymphoma postulated diagnostic marker in chronic lymphocytic leukemia (CLL/SLL). Recent data suggest prognostic importance follicular (FL). We assessed potential B-cell lymphomas. Methods Distribution PD-1+ lymphocytes lymphomas was studied 403 cases. Correlation with known biologic clinical...
Programmed death-1 (PD-1) is expressed by germinal center-associated helper T-cells and acts as a negative regulator of the immune system. PD-1 encountered on tumor cells angioimmunoblastic T-cell lymphoma postulated diagnostic marker in chronic lymphocytic leukemia (CLL/SLL). Recent data suggest prognostic importance follicular (FL). We assessed potential B-cell lymphomas.Distribution PD-1+ lymphocytes lymphomas was studied 403 cases. Correlation with known biologic clinical key performed....
Recent technological advances have led to an increase in the production and availability of single-cell data. The ability integrate a set multi-technology measurements would allow identification biologically or clinically meaningful observations through unification perspectives afforded by each technology. In most cases, however, profiling technologies consume used cells thus pairwise correspondences between datasets are lost. Due sheer size can acquire, scalable algorithms that able...
We developed tailored axillary surgery (TAS) to reduce the tumor volume in patients with clinically node-positive breast cancer point where radiotherapy can control it. The aim of this study was quantify extent load reduction achieved by TAS.
Importance The role of axillary lymph node dissection (ALND) to determine nodal burden inform systemic therapy recommendations in patients with clinically (cN)–positive breast cancer (BC) is currently unknown. Objective To address the association ALND cN-positive BC upfront surgery setting and after neoadjuvant chemotherapy (NACT). Design, Setting, Participants This was a prospective, observational, cohort study conducted from August 2018 June 2022. preplanned within phase 3 randomized...
Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read RNA sequencing (scRNA-seq) on clinical samples from three ovarian patients presenting with omental metastasis and increase PacBio depth to 12,000 reads per cell. Our approach captures 152,000 isoforms, which over 52,000 were not previously reported. Isoform-level analysis accounting for non-coding isoforms reveals 20% overestimation protein-coding gene...
Abstract Background The incidence of hepatocellular carcinoma (HCC) is increasing in the western world over past decades. As liver resection (LR) represents one most efficient treatment options, advantages anatomic (ALR) versus non‐anatomic (NALR) show a lack consistent evidence. Therefore, aim this study was to investigate complications and survival rates after both types. Methods This multicentre cohort using retrospectively prospectively collected data. We included all patients undergoing...
Curative treatments in early-stage hepatocellular carcinoma (HCC) are limited by high recurrence rates, and targeted therapies against HCC rare. Tumour microenvironment (TME) plays a crucial role. One strategy is the expression of programmed cell death receptor 1 ligand (PD-L1), whose PD-1 expressed on activated T cells. The use immune checkpoint inhibitors (ICIs) has shown antitumour activity. In HCC, ICIs proposed as possible first- second-line therapy. PD-L1 TME prognostic importance can...
Interaction between cancerous, non-transformed cells, and non-cellular components within the tumor microenvironment plays a key role in response to treatment. However, short-term culture or xenotransplantation of cancer specimens immunodeficient animals results dramatic modifications microenvironment, thus preventing reliable assessment compounds biologicals potential therapeutic relevance.We used perfusion-based bioreactor developed for tissue engineering purposes successfully maintain...
Background: Triple-negative breast cancer (TNBC) represents about 10-20% of all invasive cancers and is associated with a poor prognosis. The nectin cell adhesion protein 4 (Nectin-4) junction involved in the formation maintenance junctions. Nectin-4 has previously shown to be expressed 60% TNBC as well metastases, but absent normal tissue, which makes it potential specific target for therapy. Previous studies have an association expression worse prognosis small patient cohort. aim our study...