A5033204270- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Urologic and reproductive health conditions
- Thyroid Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Testicular diseases and treatments
- Blood Coagulation and Thrombosis Mechanisms
- HER2/EGFR in Cancer Research
- IgG4-Related and Inflammatory Diseases
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Peripheral Nerve Disorders
- Sarcoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Eosinophilic Disorders and Syndromes
- Erythrocyte Function and Pathophysiology
- Neurofibromatosis and Schwannoma Cases
- Ethics in medical practice
- Advances in Oncology and Radiotherapy
- Genetic factors in colorectal cancer
- TGF-β signaling in diseases
- Genital Health and Disease
- Empathy and Medical Education
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
Penn State Milton S. Hershey Medical Center
2016-2024
Multiple therapies currently exist for renal cell carcinoma, however, most do not result in cure and the development of acquired resistance is rule rather than exception. CDK4/6 PIM1 kinases are potential new therapeutic targets RCC. Abemaciclib a potent kinase inhibitor, thus we evaluated effects abemaciclib on carcinoma. In vitro, causes decreased cellular viability, increased apoptosis, alterations autophagy carcinoma lines. A pre-clinical mouse model RCC shows combination with sunitinib...
Prostatic ductal adenocarcinoma is an uncommon form of prostatic carcinoma. We report a case 63-year-old man who presented with non-infective thrombotic (marantic) endocarditis and incidental finding destructive lesion in the left iliac crest. Core biopsy showed carcinoma papillary architecture was initially diagnosed as "metastatic unknown origin". The patient experienced cerebral infarction expired six days later. Postmortem examination revealed extensive mixed acinar (Gleason score 5 + 4...
Key Clinical Message Non‐lupus full house nephropathy is a rare entity that still poorly understood. It can complicate post‐transplant kidneys and result in de novo process. Treatment difficult but be possibly achieved with optimization of immune suppression. Abstract an unclear incidence. describes the kidney biopsy findings positive deposits for IgG, IgA, IgM, C3, C1q on immunofluorescence absence classical diagnostic features systemic lupus nephritis. This disease becoming more recognized...
A rare case of Non-lupus full house nephropathy in a transplanted kidney, report:Ahmad Matarneh(1), Omar Salameh(2), Sundus Sardar(1), Amanda Karasinski(1), Theja Channapragada(2), Muhammad Abdulbasit(1), Erik Washburn(3), , Nasrollah Ghahramani(1)Affiliations: 1. Department nephrology, Penn state Milton S Hershey Medical Center, United States America2. Internal Medicine, America3. pathology, AmericaCorresponding authorAhmad MatarnehAffiliation: State health S.hershey medical centerContact:...
Traumatic neuromas are benign nerve sheath tumors resulting in overgrowth of fibers severed ends which the axons to Schwann cell fascicles approaches a near 1:1 ratio. They occur when has been injured and continuity cannot be reestablished. that arise penis rare difficult differentiate from condylomata without histopathologic analysis. Here, we present case patient presents with two ventral penile lesions excisional biopsy histologic analysis proved diagnostic curative.
Background: Complement-mediated hemolytic uremic syndrome (CM-HUS), formerly known as atypical HUS, is a rare but potentially fatal thrombotic microangiopathy (TMA) characterized by the triad of thrombocytopenia, microangiopathic anemia (MAHA), and acute kidney injury. It primarily caused complement dysregulation. The condition can progress to end-stage renal disease (ESRD), often necessitating transplant. In instances, it develop in post-renal-transplant patients. Methods: Here, we present...
Cerebral vein thrombosis (CVT) is a potentially fatal neurovascular disease that most commonly affects young women of child-bearing age. The risk CVT has been reported to be increased by combined oral contraceptive (COC) use. Inherited thrombophilic conditions including factor V Leiden (FVL) and prothrombin G20210A mutation also increase the CVT. Several studies have shown combination factors COC use plus an inherited disorder increases in multiplicative fashion. World Health Organization...
Urothelial melanosis is an exceptionally rare diagnosis, with less than 25 cases being reported in the literature. Melanosis of urothelium characterized by abnormal melanin deposition within tissues, producing a black, velvety appearance to urothelial mucosa. We present 67-year-old male undergoing cystoscopy during routine percutaneous nephrolithotomy (PCNL), who was found have diffuse bladder extending up ureter and into renal pelvis. To our knowledge, this first case synchronous upper...