A5048366769- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Nerve injury and regeneration
- Soft tissue tumor case studies
- Cancer-related Molecular Pathways
- Vascular Tumors and Angiosarcomas
- Oral and Maxillofacial Pathology
- Radiation Effects and Dosimetry
- Cardiac tumors and thrombi
- Science, Research, and Medicine
- Musculoskeletal synovial abnormalities and treatments
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Orthopedic Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Histiocytic Disorders and Treatments
- Management of metastatic bone disease
- Vascular Malformations and Hemangiomas
- Urologic and reproductive health conditions
University of California, San Francisco
2016-2025
UCSF Helen Diller Family Comprehensive Cancer Center
2022-2024
University of California, San Diego
1994-2022
University of California San Francisco Medical Center
2012-2022
Belfast Health and Social Care Trust
2017-2022
Cedars-Sinai Medical Center
2017-2022
El Camino Urology Medical Group
2022
Merck (Germany)
2022
Lucas Research
2020
University of Florida
2019
We report that interferon γ (IFN-γ) inhibits transcription of the macrophage scavenger receptor gene by antagonizing Ras-dependent activities AP-1 and cooperating ets domain factors, apparently as a result competition between AP-1/ets factors activated STAT1 for limiting amounts CBP p300. Consistent with this model, STAT1α interacts directly in cells, microinjection anti-CBP anti-p300 antibodies blocks transcriptional responses to IFN-γ. Cells lacking fail inhibit activity, overexpression...
The Ewing sarcoma family of tumors (EFT) is a group highly malignant small round blue cell occurring in children and young adults. We report here the largest genomic survey to date 101 EFT (65 36 lines). Using combination whole genome sequencing targeted approaches, we discover that has very low mutational burden (0.15 mutations/Mb) but frequent deleterious mutations cohesin complex subunit STAG2 (21.5% tumors, 44.4% lines), homozygous deletion CDKN2A (13.8% 50%) TP53 (6.2% 71.9%)....
Macrophage development is regulated by a complex set of hormone-like molecules and cell adhesion events that control the growth differentiation progenitor cells. The macrophage scavenger receptor (SR) gene becomes markedly upregulated during final stages monocyte-to-macrophage provides model for identification characterization transcription factors this process. In report, we have identified three genomic regulatory elements are required transactivation SR in THP-1 monocytic leukemia line...
Phosphaturic mesenchymal tumors of the mixed connective tissue type (PMTMCT) are extremely rare, histologically distinctive neoplasms, which cause tumor-induced osteomalacia (TIO) in most cases through elaboration a phosphaturic hormone, fibroblast growth factor-23 (FGF23). Rarely, identical without known TIO may be observed. We studied large group PMTMCT for expression FGF23, using novel reverse transcription polymerase chain reaction (RT-PCR) assay FGF23 formalin-fixed, paraffin-embedded...
Plexiform neurofibroma (PN) tumors are a hallmark manifestation of neurofibromatosis type 1 (NF1) that arise in the Schwann cell (SC) lineage. NF1 is common heritable cancer predisposition syndrome caused by germline mutations tumor suppressor, which encodes GTPase-activating protein called neurofibromin negatively regulates Ras proteins. Whereas most PN clinically indolent, subset progress to atypical neurofibromatous neoplasms uncertain biologic potential (ANNUBP) and/or malignant...
In recent years, a novel small round cell sarcoma harboring EWSR1-NFATC2 translocation with immunomorphologic overlap Ewing (ES), myoepithelial tumors, and extraskeletal myxoid chondrosarcoma has emerged. There not been case series devoted to describing its detailed clinicopathologic immunohistochemical characteristics. Six sarcomas fusion transcripts by reverse transcription polymerase chain reaction amplification of the gene fluorescence in situ hybridization were identified. The patients...
Intracranial mesenchymal tumors with FET-CREB fusions are a recently described group of neoplasms in children and young adults characterized by fusion FET family gene (usually EWSR1, but rarely FUS) to CREB transcription factor (ATF1, CREB1, or CREM), have been variously termed intracranial angiomatoid fibrous histiocytoma myxoid tumor. The clinical outcomes, histologic features, genomic landscape not well defined. Here, we studied 20 patients proven harbor next-generation sequencing (NGS)....
Transcription of the macrophage scavenger receptor A gene is markedly upregulated during monocyte to differentiation. In these studies, we demonstrate that 291 bp proximal promoter, in concert with a 400-bp upstream enhancer element, sufficient direct macrophage-specific expression human growth hormone reporter transgenic mice. These regulatory elements, which contain binding sites for PU.1, AP-1, and cooperating ets-domain transcription factors, are also mediate regulation transgene vitro...
Abstract Context.—Epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm of intermediate malignancy. Epithelioid often presents difficult diagnostic problem, especially in bone, because the epithelioid morphology and radiographic features raise possibility metastatic carcinoma. The current trend small biopsies obtained with computed tomography–guided techniques exacerbates problem. markedly different treatment for EHE carcinoma underscores need specific markers that can...
The diagnosis of osteosarcoma, although important for eligibility in clinical trials and proper therapy, may be challenging when no bone or osteoid matrix is identified on biopsy. Therefore, other adjunct tests have been sought to help confirm the diagnosis. Special AT-rich sequence-binding protein 2 (SATB2) has shown as a reliable marker osteoblastic differentiation. aim this study was examine SATB2 expression osteosarcomas primary sarcomas, order evaluate its diagnostic utility...
Aberrant expression of neuroendocrine markers is extremely rare in endothelial neoplasms, with only a single report describing three cases. Although originally classified as conventional angiosarcoma, further assessment these tumors revealed strikingly composite morphology composed retiform and epithelioid elements reminiscent hemangioendothelioma, subtype hemangioendothelioma. To investigate findings, available materials from 11 morphologically distinctive showing marker were retrieved our...
Secretion of beta human chorionic gonadotropin (β-hCG) is a rare, recently recognised paraneoplastic syndrome. Herein, we present case woman in her 30s with right femur conventional high-grade osteosarcoma and positive screening urine pregnancy test. Subsequent workup failed to reveal an intrauterine or extrauterine pregnancy. Rather, pathology gene expression studies confirmed serum β-hCG production by cells. Though the prognostic implications are unclear, may be useful surveillance marker...
Abstract Purpose: MPNST is the leading cause of premature death among individuals with NF1 and transcriptional aberrations that precede malignant transformation contribute to tumorigenesis remain poorly defined. Alterations involving CDKN2A components PRC2 have been implicated as early drivers PNST evolution, but these events do not occur in all MPNST. Accordingly, emerging data has begun highlight importance molecular-based stratification improve outcomes patients NF1-PNST. Experimental...