A5038834057- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Soft tissue tumor case studies
- Cardiac tumors and thrombi
- Oral and Maxillofacial Pathology
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Musculoskeletal synovial abnormalities and treatments
- Neurofibromatosis and Schwannoma Cases
- AI in cancer detection
- Cancer Genomics and Diagnostics
- Vascular Malformations and Hemangiomas
- Peptidase Inhibition and Analysis
- IgG4-Related and Inflammatory Diseases
- Histiocytic Disorders and Treatments
- Photonic and Optical Devices
- Urologic and reproductive health conditions
- CAR-T cell therapy research
- Soft tissue tumors and treatment
- Protein Degradation and Inhibitors
- Orthopedic Infections and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Total Knee Arthroplasty Outcomes
Boston Medical Center
2025
Boston University
2025
University of Michigan
2015-2024
Michigan Medicine
2009-2021
Centre for Policy Dialogue
2020
Digital Catapult
2020
Hudson Institute
2019
John Wiley & Sons (United States)
2019
A. Alfred Taubman Health Care Center
2018
Michigan Center for Translational Pathology
2013-2016
The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These Insights summarize the Panel's guideline sarcoma. data underlying these treatment are also discussed.
We performed a multi-institutional prospective phase II trial to assess late toxicities in patients with extremity soft tissue sarcoma (STS) treated preoperative image-guided radiation therapy (IGRT) reduced target volume.Patients STS received IGRT (cohort A) or without B) chemotherapy followed by limb-sparing resection. Daily pretreatment images were coregistered digitally reconstructed radiographs so that the patient position could be adjusted before each treatment. All tumor volumes...
Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little known about subtle expression patterns in other mesenchymal lesions.We performed immunohistochemical studies against the C-terminus tissue microarrays and whole sections, comprising 2366 lesions.Strong was expressed 285 2,021 tumors, including 206 240 SFTs, 49 408 well-differentiated/dedifferentiated liposarcomas, eight 65 unclassified sarcomas, 14 184 desmoid among others. SFTs...
<h3>Importance</h3> Use of next-generation sequencing (NGS) to identify clinically actionable genomic targets has been incorporated into routine clinical practice in the management advanced solid tumors; however, utility this testing remains uncertain. <h3>Objective</h3> To determine which patients derived greatest degree benefit from NGS profiling. <h3>Design, Setting, and Participants</h3> Patients cohort study underwent fresh tumor biopsy blood sample collection for profiling paired...
On the basis of a positive reported single-institution pilot study, Radiation Therapy Oncology Group initiated phase II trial 9514 to evaluate its neoadjuvant regimen in multi-institutional Intergroup setting.Eligibility included high-grade soft tissue sarcoma > or = 8 cm diameter extremities and body wall. Patients received three cycles chemotherapy (CT; modified mesna, doxorubicin, ifosfamide, dacarbazine [MAID]), interdigitated preoperative radiation therapy (RT; 44 Gy administered split...
Thirty-five cases of clear cell sarcoma soft tissues were studied to determine the clinical or morphologic features that are important in predicting prognosis. Tumors occurred most commonly extremities, and majority patients young women. Surgery was elected treatment every case. Five experienced local recurrences, metastases developed 22. Fifty-four percent died tumor, 11% alive with disease, remaining 34% well; average survival for each group 67 months, 113 103.5 respectively. This is...
Noninvasive lesions involving the lobules of breast are increasingly diagnosed as incidental microscopic findings at time lumpectomy or core-needle biopsy. We investigated incidence rates invasive cancer (IBC) after a diagnosis lobular carcinoma-in-situ (LCIS) by using Surveillance, Epidemiology, and End Results (SEER) data.Patients (N = 4,853) having primary LCIS in period 1973 to 1998 were identified SEER Public Use CD-ROM data. The database was then searched for patients with subsequent...
The clinicopathologic results from 58 patients with well-differentiated liposarcomas are reported. Thirty-two tumors involved the extremities, 20 retroperitoneum, 4 scrotum, 1 abdominal wall, and cheek. Most were large (mean, 22.6 cm). There 31 (53%) lipomalike, 23 (40%) sclerosing, (7%) primary dedifferentiated tumors. Six underwent dedifferentiation after recurrence. average follow-up period was 9.3 years. Thirty-seven (64%) alive no evidence of disease; 7 (12%) 8 (14%) died 6 (10%) other...
RNA-seq by poly(A) selection is currently the most common protocol for whole transcriptome sequencing as it provides a broad, detailed, and accurate view of RNA landscape. Unfortunately, utility libraries greatly limited when input degraded, which norm research tissues clinical samples, especially specimens are formalin-fixed. To facilitate use beyond cell lines in setting, we developed an exome-capture with improved performance on degraded RNA. Capture enable measuring absolute differential...
A subset of small round cell sarcomas remains difficult to classify. Among these, a rare tumor harboring t(4;19)(q35;q13.1) with CIC-DUX4 fusion has been described. The aim this study is better understand its clinicopathologic features. Four cases sarcoma, all arising in adults (3 women, 1 man, aged 20 43 y), were identified using conventional cytogenetic, reverse transcription polymerase chain reaction (RT-PCR) and fluorescence situ hybridization (FISH) methods. All 4 tumors demonstrated...
Solitary fibrous tumors (SFTs) of the head and neck are uncommon. Lesions previously diagnosed in as hemangiopericytomas (HPCs), giant cell angiofibromas (GCAs), orbital histiocytomas (OFHs) now recognized within expanded spectrum SFTs. To better understand clinicopathologic profile SFTs, we performed a multi-institutional study 88 examples. There was no sex predilection (F:M ratio 1.2), median patient age 52 years (range: 15 to above 89 y). The sinonasal tract orbit were most common sites...
BACKGROUND Alveolar soft part sarcoma (ASPS), chondrosarcoma (CS), chordoma, epithelioid sarcoma, and solitary fibrous tumor (SFT) are malignant tumors that relatively resistant to chemotherapy for which more effective drug therapy is needed. METHODS The 5 listed subtypes were enrolled into a single indolent cohort in phase 2 study of dasatinib using Bayesian continuous monitoring rule enrollment. primary objective was estimate the 6‐month progression‐free survival (PFS) rate according Choi...
BACKGROUND Dasatinib exhibited activity in preclinical models of sarcoma. The Sarcoma Alliance for Research through Collaboration (SARC) conducted a multicenter, phase 2 trial dasatinib patients with advanced METHODS Patients received twice daily. primary objective was to estimate the clinical benefit rate (CBR) (complete response or partial within 6 months stable disease duration ≥6 months) target ≥25%. were enrolled into 1 7 different cohorts and assessed by imaging every 8 weeks using...
Importance Pathologic complete response (pCR) may be associated with prognosis in patients soft tissue sarcoma (STS). Objective We sought to determine the prognostic significance of pCR on survival outcomes STS for receiving neoadjuvant chemoradiotherapy (CT-RT) (Radiation Therapy Oncology Group [RTOG] 9514) or preoperative image-guided radiotherapy alone (RT, RTOG 0630) and provide a long-term update 0630. Design, Setting, Participants has completed 2 multi-institutional, nonrandomized...
Aims: Differentiating sarcomatoid mesothelioma from other pleural‐based spindle cell tumours by light microscopy can be challenging, especially in a biopsy. The role of immunohistochemistry this differential diagnosis is not as well defined it for distinguishing epithelioid adenocarcinoma. In study, we investigate the utility diagnostic its histological mimics, high‐grade sarcoma and pulmonary carcinoma. Methods: We stained 20 mesotheliomas with components (10 biphasic 10 mesotheliomas)...
Abstract BACKGROUND: The use of neoadjuvant and adjuvant chemotherapy in soft tissue sarcomas is controversial. This a report long‐term (≥5 years) follow‐up patients with high‐grade, high‐risk treated chemotherapy, preoperative radiotherapy (RT), chemotherapy. METHODS: Patients high‐grade sarcoma ≥8 cm diameter the extremities body wall received 3 cycles (mesna, doxorubicin, ifosfamide, dacarbazine) RT (44 grays administered split courses), postoperative dacarbazine). RESULTS: Sixty‐four 66...