A5025285418- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Quantum, superfluid, helium dynamics
- Respiratory Support and Mechanisms
- Ultrasound and Hyperthermia Applications
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Osteoarthritis Treatment and Mechanisms
- Biochemical effects in animals
- Advanced Neuroimaging Techniques and Applications
- Polyomavirus and related diseases
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- NMR spectroscopy and applications
- Rheumatoid Arthritis Research and Therapies
- Solid-state spectroscopy and crystallography
- Congenital Diaphragmatic Hernia Studies
- MRI in cancer diagnosis
- Thermal Regulation in Medicine
- Nuclear Physics and Applications
- Effects of Environmental Stressors on Livestock
- Enzyme Structure and Function
- Gestational Trophoblastic Disease Studies
Northwell Health
2024
John T. Mather Memorial Hospital
2024
University of Pennsylvania
2012-2021
Hospital of the University of Pennsylvania
2019
Drexel University
2012
University of California, San Francisco
2011-2012
University College London
2012
University of California System
2011
United Arab Emirates University
1998
To evaluate the distribution of white matter (WM) disease in frontotemporal lobar degeneration (FTLD) and Alzheimer (AD) to relative usefulness WM gray (GM) for distinguishing these conditions vivo.Patients were classified as having FTLD (n = 50) or AD 42) using autopsy-validated CSF values total-tau:β-amyloid (t-tau:Aβ(1-42)) ratios. Patients underwent diffusion tensor imaging (DTI) volumetric MRI GM. We employed tract-specific analyses fractional anisotropy (FA) whole-brain GM density...
Purpose To assess the feasibility and optimize accuracy of multibreath wash-in hyperpolarized helium 3 ((3)He) approach to ventilation measurement by using magnetic resonance (MR) imaging as well examine physiologic differences that this reveals among nonsmokers, asymptomatic smokers, patients with chronic obstructive pulmonary disease (COPD). Materials Methods All experiments were approved local institutional review board compliant HIPAA. Informed consent was obtained from all subjects....
Background: Dry eye disease (DED) is a multifactorial condition affecting tear film stability and ocular surface health, leading to discomfort, visual impairment, reduced quality of life. Among treatment options, omega-3 fatty acid supplementation has been proposed as an alternative traditional therapies such warm compression. Omega-3 plays role in reducing inflammation improving meibomian gland function, whereas compression enhances lipid secretion stability. This study aimed compare the...
Background: Vaginal synechia is a condition in which lips of labia minora are fused and cover the opening vagina. The choice treatment depends on age group thickness. cause multifactorial, during childhood it related with hypoestrogenemia, adulthood may be to various chronic skin conditions or trauma vulva.
Osteoarthritis (OA) is a degenerative disease of the joints and results in changes biochemical composition cartilage. Previous studies have been undertaken that used high‐resolution NMR spectroscopy to study porcine, canine bovine In present study, magical angle spinning (HR‐MAS) at 11.7 T has characterize metabolites detect differences spectral signature human knee articular cartilage from non‐OA healthy cadaver knees samples acquired severe OA patients time total replacement surgery. A...
To investigate the feasibility of describing impact any flip angle-TR combination on resulting distribution hyperpolarized xenon-129 (HXe) dissolved-phase magnetization in chest using a single virtual parameter, TR90°,equiv .HXe MRI scans with simultaneous gas- (GP) and (DP) excitation were performed 2D projection mechanically ventilated rabbits. Measurements DP angles ranging from 6-90° TRs 8.3-500 ms conducted. maps based acquisitions similar radio frequency pulse-induced relaxation rates...
Background and Aims Advances in cancer treatment have improved survival; however, local recurrence metastatic disease—the principal causes of mortality—have limited the ability to achieve durable remissions. Local recurrences arise from latent tumor cells that survive therapy are often not detectable by conventional clinical imaging techniques. after transarterial embolization (TAE) hepatocellular carcinoma (HCC) provides a compelling correlate this phenomenon. In response TAE‐induced...
There is a critical need for development of biomarkers to noninvasively monitor lung transplant rejection. We investigated the potential circulating donor lung-specific exosome profiles time-sensitive diagnosis acute rejection in rat orthotopic model.Left lungs from Wistar transgenic rats expressing human CD63-GFP, an marker, were transplanted into fully MHC-mismatched Lewis recipients or syngeneic controls. Recipient blood was collected between 4 h and 10 d after transplantation, plasma...
Osteoarthritis (OA) is a degenerative disease starting with key molecular events that ultimately lead to the breakdown of cartilage. The purpose this study use two imaging methods are sensitive and macromolecular changes in OA better characterize process human osteoarthritic Human femoral condyles were collected from patients diagnosed severe during total knee replacement surgeries. T 1ρ 2 magnetic resonance measurements obtained using 3-Tesla whole body scanner assess damaged cartilage...
Abstract Acute respiratory distress syndrome (ARDS) is a major cause of mortality in critically ill patients. Patients are currently managed by protective ventilation and alveolar recruitment using positive-end expiratory pressure (PEEP). However, the PEEP’s effect on both pulmonary metabolism regional inflammation poorly understood. Here, we demonstrate PEEP anaerobic mechanically ventilated injured rats, hyperpolarized carbon-13 imaging. Pulmonary lactate-to-pyruvate ratio was measured 21...
Metabolic activity in the lung is known to change response external insults, inflammation, and cancer. We report measurements of metabolism isolated, perfused rat healthy controls diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall apparent lactate dehydrogenase shown increase significantly (on average by a factor 3.3) at 7 day stage revert substantially baseline 21 days, while other markers indicating monocarboxylate uptake transamination...
The purpose of this study was to evaluate whether regional alveolar oxygen tension ( P A O 2 ) vertical gradients imaged with hyperpolarized 3 He can identify smoking‐induced pulmonary alterations. These are compared common clinical measurements including function tests (PFTs), the six minute walk test, and St. George's Respiratory Questionnaire. 8 healthy non‐smokers, 12 asymptomatic smokers, 7 symptomatic subjects chronic obstructive disease (COPD) underwent two sets back‐to‐back imaging...
To present a method for simultaneous acquisition of alveolar oxygen tension (PA O2 ), specific ventilation (SV), and apparent diffusion coefficient (ADC) hyperpolarized (HP) gas in the human lung, allowing reinterpretation PA SV maps to produce map uptake (R).An imaging scheme was designed with series identical normoxic HP wash-in breaths measure ADC, SV, , R less than 2 min. Signal dynamics were fit an iterative recursive model that regionally solved these parameters. This measurement...
Although relatively metabolically inactive, the lung has an important role in maintaining systemic glycolytic intermediate and cytosolic redox balance. Failure to perform this function appropriately may lead disease progression, including aspects of these disorders. In study, we experimentally probe response isolated, perfused organ varying (pyruvate lactate) concentrations, effect on apparent metabolism hyperpolarized 1‐ 13 C pyruvate. Twenty‐four separate conditions were studied, from...
Abstract Many forms of lung disease manifest themselves as pathological changes in the transport gas to circulatory system, yet difficulty imaging this process remains a central obstacle comprehensive diagnosis disorders. Using hyperpolarized xenon-129 surrogate marker for oxygen, we derived temporal dynamics from ratio two images obtained with different timing parameters. Additionally, by monitoring total xenon signal intensity left side heart induced depletion alveolar airspaces interest,...
To investigate pulmonary metabolic alterations during progression of acute lung injury.Using hyperpolarized [1-13 C] pyruvate imaging, we measured lactate and in 15 ventilated rats 1, 2, 4 h after initiation mechanical ventilation. Lung compliance was used as a marker for injury progression. 5 untreated were controls; (injured-1) received 1 ml/kg another (injured-2) 2 hydrochloric acid (pH 1.25) the trachea at 70 min.The mean lactate-to-pyruvate ratio injured-1 cohort 0.15 ± 0.02 0.03...
Purpose To demonstrate the feasibility of using a 3D radial double golden‐means acquisition with variable flip angles to monitor pulmonary gas transport in single breath hold hyperpolarized xenon‐129 MRI. Methods Hyperpolarized MRI scans interleaved gas‐phase and dissolved‐phase excitations were performed mechanically ventilated rabbits. The angle was either held fixed at 15 ° or 5 °, it varied linearly ascending descending order between over sampling interval 1000 spokes. Dissolved‐phase...
The current standard for noninvasive imaging of acute rejection consists X-ray/CT, which derive their contrast from changes in ventilation, inflammation and edema, as well remodeling during rejection. We propose the use hyperpolarized [1-13 C] pyruvate MRI-which provides real-time metabolic assessment tissue-as an early biomarker tissue In this preliminary study, we used μCT-derived parameters HP 13 C MR-derived biomarkers to predict orthotopic left lung transplant model both allogeneic...
Increased pulmonary lactate production is correlated with severity of lung injury and outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted to investigate the relative contributions inflammation hypoxia lung's metabolic shift glycolysis an experimental animal model ARDS using hyperpolarized (HP) 13 C MRI. Fifty‐three intubated mechanically ventilated male rats were imaged HP MRI before, 1, 2.5 4 hours after saline (sham) or hydrochloric acid (HCl; 0.5...