A5101444229- Atomic and Subatomic Physics Research
- Respiratory Support and Mechanisms
- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Quantum, superfluid, helium dynamics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Ultrasound and Hyperthermia Applications
- Electrical and Bioimpedance Tomography
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Non-Invasive Vital Sign Monitoring
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Airway Management and Intubation Techniques
- SARS-CoV-2 detection and testing
- Electron Spin Resonance Studies
- Inhalation and Respiratory Drug Delivery
- Transplantation: Methods and Outcomes
- Ultrasound in Clinical Applications
- Neuroscience of respiration and sleep
Indiana University – Purdue University Indianapolis
2025
Indiana University School of Medicine
2025
Harvard University
2023-2024
Massachusetts General Hospital
2023-2024
Boston University
2021-2024
University of Pennsylvania
2014-2023
Methodist Hospital
2020-2023
Cornell University
2018-2023
Vanderbilt University
2023
Penn Center for AIDS Research
2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally, and proven treatments are limited. Transfusion of convalescent plasma collected from donors who have recovered COVID-19 is among many approaches being studied as potentially efficacious therapy. We conducting a prospective, propensity score-matched study assessing the efficacy transfusion versus standard care treatment for and/or critical COVID-19. present herein results an...
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the urgent need for assays that detect protective levels of neutralizing antibodies. We studied relationship among anti-spike ectodomain (anti-ECD), anti–receptor-binding domain (anti-RBD) IgG titers, and SARS-CoV-2 virus neutralization (VN) titers generated by in vitro using convalescent plasma samples from 68 patients with COVID-19. report a strong positive correlation between both anti-RBD anti-ECD...
Abstract Background There is a paucity of data concerning the optimal ventilator management in patients with COVID-19 pneumonia; particularly, levels positive-end expiratory pressure (PEEP) are unknown. We aimed to investigate effects two PEEP on alveolar recruitment critically ill severe pneumonia. Methods A single-center cohort study was conducted 39-bed intensive care unit at university-affiliated hospital Genoa, Italy. Chest computed tomography (CT) performed quantify aeration 8 and 16...
Newly emerged pathogens such as SARS-CoV-2 highlight the urgent need for assays that detect levels of neutralizing antibodies may be protective. We studied relationship between anti-spike ectodomain (ECD) and anti-receptor binding domain (RBD) IgG titers, virus neutralization (VN) titers generated by two different in vitro using convalescent plasma samples obtained from 68 COVID-19 patients, including 13 who donated multiple times. Only 23% (16/68) donors had been hospitalized. also 16...
Abstract Background Critically ill COVID-19 patients have pathophysiological lung features characterized by perfusion abnormalities. However, to date no study has evaluated whether the changes in distribution of pulmonary gas and blood volume are associated with severity gas-exchange impairment type respiratory support (non-invasive versus invasive) severe pneumonia. Methods This was a single-center, retrospective cohort conducted tertiary care hospital Northern Italy during first pandemic...
Objective: Atelectasis and surfactant depletion may contribute to greater distension—and thereby injury—of aerated lung regions; recruitment of atelectatic protect these regions by attenuating such overdistension. However, the effects atelectasis (and recruitment) on airspaces remain elusive. We tested hypothesis that during mechanical ventilation, increases dimensions reverses changes. Design: Prospective imaging study in an animal model. Setting: Research facility. Subjects: Twenty-seven...
Uncertain prediction of outcome in acute respiratory distress syndrome (ARDS) impedes individual patient management and clinical trial design.To develop a radiological metric injurious inflation derived from matched inspiratory expiratory CT scans, calibrate it model experimental lung injury, test patients with ARDS.73 anaesthetised rats (acid aspiration model) were ventilated (protective or non-protective) for up to 4 hours generate spectrum injury. was performed (inspiratory expiratory) at...
Purpose To assess the feasibility and optimize accuracy of multibreath wash-in hyperpolarized helium 3 ((3)He) approach to ventilation measurement by using magnetic resonance (MR) imaging as well examine physiologic differences that this reveals among nonsmokers, asymptomatic smokers, patients with chronic obstructive pulmonary disease (COPD). Materials Methods All experiments were approved local institutional review board compliant HIPAA. Informed consent was obtained from all subjects....
Coarse-grained (CG) molecular dynamics of proteins is a preferred approach to studying large molecules on extended time scales by condensing the entire atomic model into limited number pseudo-atoms and preserving thermodynamic properties system. However, significantly increased efficiency impedes analysis substantial physicochemical information, since high-resolution details are sacrificed accelerate simulation. In this paper, we propose LatCPB, generative based diffusion that enables...
It remains unclear how prone positioning improves survival in acute respiratory distress syndrome. Using serial computed tomography (CT), we previously reported that "unstable" inflation (i.e., partial aeration with large tidal density swings, indicating increased local strain) is associated injury progression.
The superimposed pressure is the primary determinant of pleural gradient. Obesity associated with elevated end-expiratory esophageal pressure, regardless lung disease severity, and might not be only study aims to measure partitioned respiratory mechanics in a cohort patients admitted ICU without class III obesity (BMI ≥ 40 kg/m
The aim of this study was to assess the utility 3 He MRI noninvasively probe effects positive end-expiratory pressure (PEEP) maneuvers on alveolar recruitment and atelectasis buildup in mechanically ventilated animals. Sprague-Dawley rats ( n = 13) were anesthetized, intubated, supine position 4 He-to-O 2 ratio: 4:1; tidal volume: 10 ml/kg, 60 breaths/min, inspiration-to-expiration 1:2). Recruitment consisted either a stepwise increase PEEP 9 cmH O back zero or alternating between these two...
A novel approach of ECG baseline wander correction based on mean-median filter and empirical mode decomposition is presented in this paper. The low frequency parts the original signals were removed by mean median a nonlinear way to o
Abstract Background Mechanical ventilation worsens acute respiratory distress syndrome, but this secondary “ventilator-associated” injury is variable and difficult to predict. The authors aimed visualize the propagation of such ventilator-induced injury, in presence (and absence) a primary underlying lung determine predictors propagation. Methods Anesthetized rats (n = 20) received acid aspiration (hydrochloric acid) followed by with moderate tidal volume (VT). In animals surviving for at...
Background Bedside electrical impedance tomography could be useful to visualize evolving pulmonary perfusion distributions when acute respiratory distress syndrome worsens or in response ventilatory and positional therapies. In experimental syndrome, this study evaluated the agreement of dynamic contrast–enhanced computed at two injury time points increased positive end-expiratory pressure (PEEP) prone position. Methods Eleven mechanically ventilated (VT 8 ml · kg−1) Yorkshire pigs (five...
To investigate the feasibility of describing impact any flip angle-TR combination on resulting distribution hyperpolarized xenon-129 (HXe) dissolved-phase magnetization in chest using a single virtual parameter, TR90°,equiv .HXe MRI scans with simultaneous gas- (GP) and (DP) excitation were performed 2D projection mechanically ventilated rabbits. Measurements DP angles ranging from 6-90° TRs 8.3-500 ms conducted. maps based acquisitions similar radio frequency pulse-induced relaxation rates...
Dynamic contrast-enhanced CT using a lower-viscosity contrast agent in combination with tracer-kinetic analysis by the steepest-slope model improves pulmonary blood flow measurements and assessment of regional distributions lung perfusion.
Electrical impedance tomography is an emerging tool to measure regional lung perfusion using kinetic analysis of a conductive indicator. Hypertonic sodium chloride the standard agent used. We measured another indicator, comparing hypertonic bicarbonate in experimental swine injury model. found strong agreement between two indicators. Sodium may be comparable indicator with electrical tomography.