A5088082429- Plant Virus Research Studies
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Plant-Microbe Interactions and Immunity
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Nuclear Structure and Function
- Lysosomal Storage Disorders Research
- RNA modifications and cancer
- Plant Molecular Biology Research
- Insect-Plant Interactions and Control
- Telomeres, Telomerase, and Senescence
- Immune Cell Function and Interaction
- Genetic Neurodegenerative Diseases
- Dental Radiography and Imaging
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Hereditary Neurological Disorders
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- Carbohydrate Chemistry and Synthesis
- Formal Methods in Verification
- Facial Trauma and Fracture Management
Peking University
2015-2025
Nanjing Maternity and Child Health Care Hospital
2024
Nanjing Medical University
2024
Dalian Medical University
2022
Second Affiliated Hospital of Dalian Medical University
2022
State Key Laboratory of Protein and Plant Gene Research
2020
Union Hospital
2019-2020
Huazhong University of Science and Technology
2019-2020
Tongji Hospital
2019
Central Hospital of Zibo
2019
Copper is a critical regulator of plant growth and development. However, the mechanisms by which copper responds to virus invasion are unclear. We previously showed that SPL9-mediated transcriptional activation miR528 adds unidentified regulatory layer established ARGONAUTE (AGO18)–miR528– L-ascorbate oxidase ( AO ) antiviral defense. Here, we report rice promotes accumulation in shoots inducing transporter genes, including HMA5 COPT , counteract viral infection. suppresses inhibiting...
Hutchinson-Gilford progeria syndrome (HGPS) and Werner (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting production truncated protein product—progerin. WS mutations WRN encoding loss-of-function RecQ DNA helicase. Here, gene editing we created isogenic embryonic stem cells (ESCs) with heterozygous (G608G/+) or homozygous (G608G/G608G) LMNA biallelic knockout, for modeling pathogenesis, respectively. While...
There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles regulating myriad aspects of plant development, but their role (s) host antiviral immune defense and underneath mechanism remain largely unknown. By using rice-rice dwarf virus (RDV) model system, here we report that signaling enhances against RDV infection. In turn, infection triggers increased biosynthesis accumulation rice, treatment with exogenous reduces OsIAA10 protein level, thereby unleashing a...
Cockayne syndrome (CS) is a rare autosomal recessive inherited disorder characterized by variety of clinical features, including increased sensitivity to sunlight, progressive neurological abnormalities, and the appearance premature aging. However, pathogenesis CS remains unclear due limitations current disease models. Here, we generate integration-free induced pluripotent stem cells (iPSCs) from fibroblasts patient bearing mutations in CSB/ERCC6 gene further derive isogenic gene-corrected...
Purpose Facioscapulohumeral muscular dystrophy (FSHD) is a common adult dystrophy. Over 95% of FSHD cases are associated with contraction the D4Z4 tandem repeat (~3.3 kb per unit) at 4q35 specific genomic configuration (haplotype) called 4qA. Molecular diagnosis typically requires pulsed-field gel electrophoresis Southern blotting. We aim to develop novel and computational methods for characterising numbers in FSHD. Methods leveraged single-molecule optical mapping platform that maps...
Crop production faces persistent threats from insect-vector-borne viral diseases1,2. Recent advancements have revealed the intricate immune mechanisms that plants deploy against pathogens3–8. However, molecular through which plant hosts recognize infections and initiate antiviral defence at disease onset not been elucidated. Here, natural infection of rice by inoculation with insect vectors carrying forms viruses, we show coat proteins are perceived RING1–IBR–RING2-type ubiquitin ligase...
The survival and colonization of tumor cells at new locations involve a variety complex genetic, epigenetic, microenvironmental factors. TRIM24 was originally named transcription intermediary factor 1-alpha (TIF1α), which associated with cellular proliferation an oncogene in development. Here we provide the first evidence expression profile clinicopathological significance patients hepatocellular carcinoma (HCC). Immunohistochemistry employed to determine level HCC tissues noncancerous liver...
Pompe disease is an autosomal recessive lysosomal glycogen storage disorder that has been reported in different ethnic populations which carry common mutations of the acid alpha-glucosidase (GAA) gene. The GAA mutation pattern mainland Chinese patients with late-onset still not well understood. We presented clinical and genetic characteristics 27 from 24 families. analysis revealed 26 mutations, including 10 were novel. allelic frequency c.2238G > C (p.W746C) was found to be 27.08% this...
Significance Genomic instability fuels tumor progression and treatment resistance in cancer. Causative factors means for clinical detection of genomic the bulk gliomas have been inadequately explored. We identify a conserved gene coexpression module centered on CDC20 (CDC20-M) glioma transcriptomes that encompasses broad activities cell proliferation genome maintenance. show high CDC20-M expression robustly predicts poor prognosis severe chromosomal mutation burden glioma. Core members...
Abstract Autophagy is a highly conserved lysosome‐mediated protective cellular process in which cytosolic components, including damaged organelles and long‐lived proteins, are cleared. Many studies have shown that autophagy was upregulated hypoxic regions. However, the precise molecular mechanism of hypoxia‐induced colorectal cancer (CRC) still elusive. In this study, we found miR‐20a significantly downregulated under hypoxia colon cells, overexpression alleviated autophagy. Moreover,...
Abstract Background With the advent of CAD/CAM and rapid prototyping (RP), a technical revolution in oral maxillofacial trauma was promoted to benefit treatment, repair fractures reconstruction defects. Methods For patient with zygomatico‐facial collapse deformity resulting from zygomatico‐orbito‐maxillary complex (ZOMC) fracture, CT scan data were processed by using Mimics 10.0 for three‐dimensional (3D) reconstruction. The reduction design aided 3D virtual imaging skull model reproduced RP...
Mandibuloacral dysplasia type A (MADA) is a rare autosomal recessive disorder, characterized by growth retardation, skeletal abnormality with progressive osteolysis of the distal phalanges and clavicles, craniofacial anomalies mandibular hypoplasia, lipodystrophy mottled cutaneous pigmentation. Some patients may show progeroid features. MADA partial lipodystrophy, more marked acral, can be caused homozygous or compound heterozygous mutation in gene encoding lamin C (LMNA). Hutchinson-Gilford...
Purpose: The present study aims to explore the potential mechanisms contributing prostate cancer (PCa), screen hub genes, and identify biomarkers correlated pathways of PCa progression.Methods: gene expression profile GSE3325 was operated analyze differentially expressed genes (DEGs).DAVID used evaluate Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses.A protein-protein interaction (PPI) network constructed visualize interactions genes.The prognostic diagnostic analysis...
Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized mainly by progressive cerebellar ataxia, oculocutaneous telangiectasia, and immunodeficiency. This caused mutations of the ataxia mutated (Atm) gene. More than 500 Atm that are responsible for A-T have been identified so far. However, there very few cases reported in China, only two Chinese patients undergone gene analysis. In order to systemically investigate China map their mutation spectrum, we recruited eight...
Abstract There are two genetics complementary groups Cockayne syndrome type A and B (CS-A CS-B OMIM 216400, 133540), which is a rare autosomal recessive segmental progeroid syndrome. Homozygous or compound heterozygous mutations in the excision repair cross-complementation group 8 gene ( ERCC8 ) result CS-A, ERCC6 CS-B. ERCC6/ERCC8 also UV-sensitive In this study, twenty-one Han Chinese patients with CS were investigated to identify / , of thirteen cases CS-A identified . five types our such...
To explore the clinical features of a novel glycyl-tRNA synthetase (GARS) gene mutation in family with Charcot–Marie–Tooth disease type 2D (CMT2D).
Hematopoietic stem cell (HSC) regulation is highly dependent on interactions with the marrow microenvironment, of which osteogenic cells play a crucial role. While evidence accumulating for an important role intrinsic miR-17 in regulating HSCs and HPCs, whether signaling pathways are also necessary cell-extrinsic control hematopoiesis hereto remains poorly understood.Using immortalized clone characteristics osteoblasts, FBMOB-hTERT, vitro expansion, long-term culture initiating (LTC-IC)...
Innate and adaptive immune responses play critical roles in the body's defense against viruses. We investigated host response 2009 pandemic H1N1 influenza virus [A(H1N1)pdm09] patients before after anti-influenza therapy found that numbers of dendritic cells T were significantly reduced compared with those a healthy control group. In contrast, frequency natural killer, γδT regulatory (Treg) increased, concentrations plasma interferon (IFN)-α/γ interleukin (IL-15) higher than control....
Background: Cockayne syndrome is a rare, autosomal recessive, multisystem disorder that causes senile appearance. Ophthalmic abnormalities are frequently present. Here, we report wide range of ocular findings in child with syndrome.Materials and methods: The systemic were reviewed. A mutation analysis was performed the patient her parents.Results: underwent complete examination. Both eyes had low visual acuity, corneal epithelial degeneration, punctate opacities lens, retina disorders....