A5068149257- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Biopolymer Synthesis and Applications
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Renal cell carcinoma treatment
- Digestive system and related health
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Biological Research and Disease Studies
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Esophageal Cancer Research and Treatment
- Estrogen and related hormone effects
- DNA Repair Mechanisms
- Prostate Cancer Treatment and Research
- Genetic Syndromes and Imprinting
Shenzhen Institutes of Advanced Technology
2021-2025
Chinese Academy of Sciences
2022-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2014-2025
University Town of Shenzhen
2025
Huzhou Women and Children's Hospital
2025
Ministry of Agriculture and Rural Affairs
2018-2024
Animal Science Research Institute
2011-2024
First Affiliated Hospital of Bengbu Medical College
2024
Union Hospital
2013-2023
Huazhong University of Science and Technology
2014-2023
Highlights•871 predisposition variants/CNVs discovered in 8% of 10,389 cases 33 cancers•Pan-cancer approach identified shared variants and genes across cancers•33 affecting activating domains oncogenes showed high expression•47 VUSs prioritized using cancer enrichment, LOH, expression other evidenceSummaryWe conducted the largest investigation to date, discovering 853 pathogenic or likely from types. Twenty-one single cross-cancer associations, including novel associations SDHA melanoma...
Renal cell carcinoma (RCC) is one of the most frequently observed malignant tumours in urinary system and targeted drug resistance quite common RCC. Long noncoding RNA SNHG12 (lncRNA SNHG12) has emerged as a key molecule numerous human cancers, but its functions renal sunitinib remain unclear. In this study, we found was highly expressed RCC tissues sunitinib-resistant cells associated with poor clinical prognosis. promoted proliferation, migration, invasion via CDCA3 vitro. Mechanically,...
Abstract Clear cell renal carcinoma (ccRCC) is the most common malignant tumor of kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis prognosis. The CENP family overexpressed many types cancers, but its functions have not been fully clarified. In this paper, we found that several members were highly expressed tissues. Also, CENPA expression level was related to clinicopathological grade prognosis by weighted gene co-expression network analysis (WGCNA). served as a...
// Yong Chen 1 , Ju Mei Liu Xin Xiong Yao Qiu Feng Pan 2 Di Shu Jue Lan 3 Si Jin 4 Shang Bin Yu and Xiao Qian Department of Pathophysiology, School Basic Medicine, Tongji Medical College, Institute Brain Research, Key Laboratory Neurological Diseases, Ministry Education, Hubei Provincial Huazhong University Science Technology, Wuhan, China Urology, Union Hospital, Biochemistry Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy Shanghai, Pharmacology, Correspondence...
This study aimed to explore the effects of two siderophore-producing bacterial strains on iron absorption and plant growth peanut in calcareous soil. Two strains, namely, YZ29 DZ13, isolated from rhizosphere soil peanut, were identified as Paenibacillus illinoisensis Bacillus sp., respectively. In potted experiments, DZ13 enhanced root activity, chlorophyll active content leaves, total nitrogen, phosphorus potassium accumulation plants increased quality kernels biomass over control. field...
Clear cell renal carcinoma (ccRCC) is the most common malignancy in adults, incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), was originally considered an RNA transcript, markedly expressed during adipocyte differentiation. In addition, it has been observed be elevated numerous types cancer, including ccRCC; however, its essential function remains unclear ccRCC. present study examined expression PLIN2 ccRCC, and aimed determine association between...
Emerging evidence indicates that castration-resistant prostate cancer (CRPC) is often driven by constitutively active androgen receptor (AR) or its V7 splice variant (AR-V7) and commonly becomes resistant to endocrine therapy. The aim of this work evaluate the function a kinesin protein, KIF4A, in regulating AR/AR-V7 therapy resistance.We examined KIF4A expression clinical specimens IHC. Regulated pathways were investigated qRT-PCR, immunoblot analysis, immunoprecipitation, luciferase...
Kidney cancer ranked in the top 10 for both men and women estimated numbers of new cases United States 2018. Targeted therapies have recently been administered to patients with clear cell renal carcinoma (ccRCC), but overall survival at terminal stage disease has not as good expected. It is therefore necessary uncover efficient biomarkers early diagnosis, clarify molecular mechanisms underlying ccRCC progression metastasis. Increased evidence shown that long non-coding RNAs (lncRNAs) play...
Clear cell renal carcinoma (ccRCC) is one of the most common malignancies and lacks reliable biomarkers for diagnosis prognosis, which results in high incidence mortality rates ccRCC. In this study, ISG20, HJURP, FOXM1 were identified as hub genes via weighted gene co-expression network analysis (WGCNA) Cox regression analysis. Samples validation showed that only ISG20 was up-regulated Therefore, selected further study. High expression associated with poor overall survival disease-free...
Type 2 diabetes mellitus (T2DM) is associated with cardiovascular disease (CVD) and sodium glucose cotransporter inhibitors, as oral medications for T2DM treatment have shown the potential to improve vascular dysfunction. The aim of this study was evaluate ability canagliflozin (Cana) relieve CVD in mice its possible action mechanism. Mice diabetic conducted by a high-fat diet 24 weeks, followed gavaging metformin (200 mg/kg/day) or Cana (50 6 weeks. result demonstrated that reduced serum...
Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the associated with IBS, while accounting for impact of unobserved confounders and coexisting disorders. Methods Genetic correlation Mendelian randomisation (MR) analyses were integrated identify disorders linked IBS. Subsequently, multiresponse MR (MR 2 ) was employed further examine these associations. Summary-level genome-wide...
<title>Abstract</title> Background: Cancer remains a leading cause of female mortality worldwide, especially in low- and middle-income countries. While lifestyle contributes to cancer causation, the extent its burden on women across different populations unclear. Method: We conducted study investigate role six factors—low physical activity, alcohol consumption, high fasting plasma glucose, dietary, tobacco, body-mass index (BMI)—in among globally, regionally, nationally from 1990 2021....
Lung adenocarcinoma (LUAD) continues to be a primary cause of cancer-related mortality globally, highlighting the urgent need for novel insights finto its molecular mechanisms. This study aims investigate relationship between gene expression and mitophagy in LUAD, with an emphasis on identifying key biomarkers elucidating their roles tumorigenesis immune cell infiltration. We utilized datasets GSE151101 GSE203609 from Gene Expression Omnibus (GEO) database identify differentially expressed...
Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy.The aim this study is to investigate MGO itch and hypoalgesia, two common symptoms associated with neuropathy.Methods: Scratching behavior, mechanical (alloknesis), thermal hypoalgesia were quantified after intradermal (i.d.) injection naïve mice or induced by intraperitoneal (i.p.) streptozotocin (STZ).Behavioral testing, patch-clamp recording, transgenic mice, gene...
Clear cell renal carcinoma (ccRCC) is one of the most common malignancies in urinary system. However, there are still no reliable biomarkers for diagnosis and prognosis ccRCC. In this study, we aimed to screen candidate potential therapeutic targets Differentially expressed genes (DEGs) were screened using NetworkAnalyst. Protein-protein interaction (PPI) network weighted gene co-expression analysis (WGCNA) utilized identify hub genes. Then, assessed prognostic diagnostic values biomarkers....
Renal cell carcinoma (RCC) is one of the most common malignancies in urinary system. The mortality advanced RCC remains high despite advances systemic therapy RCC. Considering misdiagnosis early-stage RCC, identification effective biomarkers great importance. Tissue inhibitor matrix metalloproteinase 1 (TIMP1), which belongs to TIMP gene family, a natural metalloproteinases (MMPs). In this study, we found TIMP1 was significantly up-regulated lines and tissues. Kaplan-Meier analysis revealed...
Abstract As the most prominent RNA modification, N6‐methyladenosine (m 6 A) participates in regulation of tumour initiation and progression. Circular RNAs (circRNAs) also play crucial roles ubiquitous life processes. Whether circRNAs are required for m A renal cell carcinoma (RCC) remains unclear. Meta‐analysis bioinformatics identified that IGF2BP3 was upregulated RCC indicated a worse prognosis. significantly promoted progression vitro vivo. Mechanistically, circRARS bound to KH1–KH2...
IgA nephropathy (IgAN) has been considered to be the most frequent form of primary glomerulonephritis that occurs worldwide with a variety factors involved in its occurrence and development. The impact autophagy IgAN, however, remains partially unclear. This study was designed investigate effects rapamycin an IgAN model.After establishing rat model, SD rats were divided into 4 groups: control, control + rapamycin, rapamycin. Proteinuria pathological changes level kidney texted. Identify...