A5101725175- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Pancreatic and Hepatic Oncology Research
- Renal and related cancers
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Microbial Inactivation Methods
- Immune cells in cancer
- Real-Time Systems Scheduling
- Network Time Synchronization Technologies
- Histone Deacetylase Inhibitors Research
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced machining processes and optimization
Union Hospital
2019-2024
Huazhong University of Science and Technology
2005-2024
82th Hospital of Pla
2024
Southern Medical University
2018-2024
Peking University First Hospital
2024
Peking University
2024
National Center of Ocean Standards and Metrology
2023
Wuhan Union Hospital
2017-2023
Second Affiliated Hospital of Jilin University
2016-2023
Eighth Affiliated Hospital of Sun Yat-sen University
2023
Abstract BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated transcription is required tumor cells to develop drug resistance. Our data show prolonged treatment luminal breast with AKT inhibitors induces FOXO3a dephosphorylation, nuclear translocation, disrupts its association SirT6, eventually leading acetylation as well recognition. Acetylated...
Renal cell carcinoma (RCC) is a serious threat to people's health due its rapid progression, and patients easily develop resistance targeted therapy.The absent in melanoma 2 (AIM2) receptor protein that has recently been proposed play an important role various diseases.In this study, AIM2 was identified as new biomarker of RCC promoted progression sunitinib inflammasome-independent manner.Mechanistically, FOXO3a phosphorylation proteasome degradation, thereby reducing transcriptional effect...
The mechanism of metabolism reprogramming is an unsolved problem in clear cell renal carcinoma (ccRCC). Recently, it was discovered that the Hippo pathway altered tumor and promoted progression. Thus, this study aimed at identifying key regulators ccRCC pinpointing potential therapeutic targets for patients.Hippo-related gene sets metabolic were used to screen ccRCC. Public databases samples from patients applied investigate association dihydrolipoamide branched chain transacylase E2 (DBT)...
Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear-cell renal cell carcinoma (ccRCC). N-acetyltransferase 10 (NAT10) known to catalyze N4-acetylcytidine (ac
Rationale: Twist is a key transcription factor for induction of epithelial-mesenchymal transition (EMT), which promotes cell migration, invasion, and cancer metastasis, confers cells with stem cell-like characteristics, provides therapeutic resistance. However, the functional roles targeted genes in EMT progression remain elusive. Methods: The potential were identified from global transcriptomes T47D/Twist by microarray analysis. phenotype was detected western blotting immunofluorescence...
Abstract Clear cell renal carcinoma (ccRCC) is the most common malignant tumor of kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis prognosis. The CENP family overexpressed many types cancers, but its functions have not been fully clarified. In this paper, we found that several members were highly expressed tissues. Also, CENPA expression level was related to clinicopathological grade prognosis by weighted gene co-expression network analysis (WGCNA). served as a...
This review discussed photothermal therapy from basic information to its circumstances and potential in protate cancer treatment.
Two robust tree-ring width chronologies were developed for the western Tianmu Moun- tains and Xianyu Mountains of southeast China. Both significantly correlated with each other arithmetically averaged to build a regional chronology (RC). The RC had significant positive correlations winter temperature before growing season. Based on this relationship, average temperatures previous December current March reconstructed using period 1852 2006. reconstruction was half-year in eastern Qinling...
Cellular metabolism supports immune cell function. Here, we identify a reduction in fatty acid synthesis and mitochondrial dendritic cells (DC) due to α-fetoprotein (AFP), protein secreted by hepatocellular cancer (HCC). DCs cultured the presence of AFP show reduced expression metabolic regulatory molecules SREBP-1 PGC1-α. The negative effect on ATP production was confirmed with observation basal oxygen consumption rate (OCR) exposed derived from cord blood. More severe OCR observed...
Abstract Emerging evidence has highlighted the important role of abnormal lipid accumulation in cancer development and progression, but mechanism for this phenomenon remains unclear. Here, it is demonstrated that phospholipase C‐like 1/uncoupling protein 1 (PLCL1)/(UCP1)‐mediated browning promotes tumor cell “slimming” represses progression. By screening three independent metabolism‐related gene sets clear renal carcinoma (ccRCC) analyzing TCGA database, found PLCL1 predicted a poor...
Clear cell renal carcinoma (ccRCC) is one of the most common malignancies and lacks reliable biomarkers for diagnosis prognosis, which results in high incidence mortality rates ccRCC. In this study, ISG20, HJURP, FOXM1 were identified as hub genes via weighted gene co-expression network analysis (WGCNA) Cox regression analysis. Samples validation showed that only ISG20 was up-regulated Therefore, selected further study. High expression associated with poor overall survival disease-free...
Abstract Cancer cachexia is a metabolic disorder characterized by skeletal muscle wasting and white adipose tissue browning. Specific functions of several hormones, growth factors, cytokines derived from tumors can trigger cachexia. Moreover, lipolysis might explain weight loss that occurs owing to Extracellular vesicles (EVs) are involved in intercellular communication. However, whether EVs participate induced cancer has not been thoroughly investigated. Using Lewis lung carcinoma (LLC)...
Background Acute kidney injury (AKI) is a major complication after acute type A aortic dissection (ATAAD), with an incidence rate of 20–66.7%. Many patients AKI ATAAD surgery show no clear signs ischemia-reperfusion injury. In our previous study, S100A8 and S100A9 were identified as predictive biomarkers surgery. These proteins are primarily expressed in neutrophils macrophages, where they contribute to cell damage immune activation. However, the roles S100A8/A9 ATAAD-associated remain...
Tumor cells must activate specific transporters to meet their increased glutamine metabolic demands. Relative other transporters, the ASC family transporter 2 (ASCT2, also called SLC1A5) is profoundly elevated in a wide spectrum of human cancers coordinate reprogramming and malignant transformation. Understanding molecular mechanisms whereby tumor frequently upregulate this therefore vital develop potential strategies for transporter-targeted therapies. Combining in-silico algorithms with...
Sex differences in glioma incidence and outcome have been previously reported but remain poorly understood. Many sex that affect the cancer risk were thought to be associated with evolution. In this study, we used an integrated framework infer timing clonal status of mutations ~600 diffuse gliomas from The Cancer Genome Atlas (TCGA) including glioblastomas (GBMs) low-grade (LGGs), investigated difference mutation clonality. We observed higher overall subclonal burden female patients...
Pancreatic cancer is one of the most challenging types in clinical treatment worldwide. This study aimed to understand tumorigenesis mechanism and explore potential therapeutic targets for patients with pancreatic cancer. Single-cell data expression profiles samples normal tissues from multiple databases were included. Comprehensive bioinformatics analyses applied clarify tumor microenvironment identify key genes involved development. Immense difference cell was shown between samples. Four...
Abstract Background Clear cell renal carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the importance autophagy in ccRCC has been focused, it potential connections with HIF-2α metabolism. However, specific regulatory mechanism between HIF-2α, autophagy, still unclear. Methods In this study, Bioinformatics Analysis Sequencing whole transcriptome were used to screen our target. The expression TBC1D5 clear was confirmed by database analysis,...
CR Climate Research Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 53:157-167 (2012) - DOI: https://doi.org/10.3354/cr01098 Growth response of Pinus tabulaeformis climate along an elevation gradient in eastern Qinling Mountains, central China Jiangfeng Shi1,2,*, Jinbao Li3, Edward R. Cook4, Xiaoye Zhang5, Huayu Lu1 1School Geographic and Oceanographic Sciences, Institute for Global Change...
Abstract Differences in genetic molecular features including mutation, copy number alterations and DNA methylation, can explain interindividual variability response to anti-cancer drugs cancer patients. However, identifying alteration-driven genes characterizing their functional mechanisms different types are still major challenges for studies. Here, we systematically identified regulations between drug target potential prognostic roles breast cancer. We two mutation number-driven gene pairs...
Hypoxia-induced endothelial cell death and impaired angiogenesis are the main pathophysiological features of critical limb ischemia. Mechanistically, proprotein convertase subtilisin/kexin type 9 (PCSK9) promoted Smac translocation from mitochondria to cytoplasm. Inhibition release into cytoplasm attenuated PCSK9-mediated hypoxia-induced pyroptosis. Functionally, PCSK9 overexpression in vitro reduced blood perfusion mice with lower ischemia, but effect was reversed by inhibition. This study...