A5057112106- Radiopharmaceutical Chemistry and Applications
- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Nanoparticle-Based Drug Delivery
- Medical Imaging and Pathology Studies
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Photodynamic Therapy Research Studies
- Parathyroid Disorders and Treatments
- Cancer-related Molecular Pathways
- Electrolyte and hormonal disorders
- Lung Cancer Treatments and Mutations
- Mechanical Failure Analysis and Simulation
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Renal and Vascular Pathologies
- Thyroid and Parathyroid Surgery
- Gear and Bearing Dynamics Analysis
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Sphingolipid Metabolism and Signaling
Huazhong University of Science and Technology
2016-2025
Ministry of Education of the People's Republic of China
2022-2025
China Telecom (China)
2025
Union Hospital
2015-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2016-2024
Union Hospital
2010-2024
Minzu University of China
2023
Massachusetts General Hospital
2021-2023
Harvard University
2021-2023
Northwest Minzu University
2023
Abstract Purpose Lung metastasis (LM) is one of the most frequent distant metastases thyroid cancer (TC). This study aimed to develop a machine learning algorithm model predict lung for providing relative information in clinical decision‐making. Methods Data comprising demographic and clinicopathological characteristics patients with were extracted from National Institutes Health (NIH)’s Surveillance, Epidemiology, End Results (SEER) database between 2010 2015, which employed six models...
This review discussed photothermal therapy from basic information to its circumstances and potential in protate cancer treatment.
Alterations in brain cholesterol homeostasis have been broadly implicated neurological disorders. Notwithstanding the complexity by which biology is governed mammalian brain, excess neuronal primarily eliminated metabolic clearance via cytochrome P450 46A1 (CYP46A1). No methods are currently available for visualizing metabolism living human brain; therefore, a noninvasive technology that quantitatively measures extent of CYP46A1 could affect disease diagnosis and treatment options using...
Under the background of education informatization, establishment digital and intelligent smart campus platform has become an inevitable trend, aiming at realizing education, management service. Based on big data technology, this paper applies machine learning technology to study student behavior portrait build a comprehensive portrait. The main research focuses building models using algorithms, especially solving challenge that K-means algorithms are susceptible local optimal solutions. To...
Renal dynamic scintigraphy is a crucial diagnostic tool for assessing renal function, yet unexpected findings can provide additional insights into extrarenal conditions. We report 2 rare cases of 99m Tc-DTPA uptake associated with adrenal tumors: one cortical carcinoma and pheochromocytoma. In both cases, significant tracer accumulation in the region was observed, highlighting an uncommon but noteworthy consideration. These emphasize importance including tumors differential diagnosis when...
Introduction. Radiolabeled gold nanoparticles play an important role in biomedical application. The aim of this study was to prepare iodine-131 ( 131 I)-labeled nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging integrin<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>α</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">v</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> β...
Abstract: The purpose of this study was to compare mammography and sonography, as well their combination, for detecting breast tumors in symptomatic patients. effects age hormonal status were also examined. From 1999 2007, 549 patients underwent 665 examination sessions (mammography ultrasound). Abnormalities deemed positive if biopsy findings revealed malignancy negative from or all screening examinations negative. On pathology, 246 lesions malignant 419 benign the sensitivity, specificity,...
Approximately half of the documented increases in differentiated thyroid carcinoma is due to identification papillary microcarcinomas (PTMCs). Knowing whether PTMC aggressive required for proper treatment, but until now, there has been no method assessing these traits and understanding underlying mechanisms aggressiveness.We performed whole-exome sequencing 16 PTMCs matched normal tissues GO/KEGG analysis study genetic alterations biological consequences associated with PTMCs, then sequenced...
Monoacylglycerol lipase (MAGL) is a 33 kDa serine protease primarily responsible for hydrolyzing 2-arachidonoylglycerol into the proinflammatory eicosanoid precursor arachidonic acid in central nervous system. Inhibition of MAGL constitutes an attractive therapeutic concept treating psychiatric disorders and neurodegenerative diseases. Herein, we present design synthesis multiple reversible inhibitor candidates based on piperazinyl azetidine scaffold. Compounds 10 15 were identified as...
Purpose: To develop a heterogeneous ensemble algorithm model to precisely predict central lymph node metastasis (CLNM), which can provide reference value on controversial topics of performing prophylactic dissection for patients with papillary thyroid cancer (PTC). Methods: The study included PTC who underwent an initial resection in single-center medical institution between January 2014 and December 2018. A total 18 variables, including clinical features ultrasound (US) features, were used...
Background. The BRAF V600E mutation is an important genetic event in papillary thyroid cancer (PTC). This study aimed to provide additional information regarding the association of with PTC prognosis. Methods. A retrospective single-center based on a Chinese population was performed analyze several clinicopathological features. Kaplan–Meier survival curves and Cox proportional hazards regression analysis were applied implement analysis. Results. present 1102 (87.7%) 1257 patients...
Nowadays, pancreatic cancer is still a formidable disease to diagnose. The CXC chemokine receptor 4 (CXCR4) and integrin αvβ3 play important roles in tumor development, progression, invasion, metastasis, which are overexpressed many types of human cancers. In this study, we developed heterodimeric tracer 68Ga-yG5-RGD targeting both CXCR4 αvβ3, evaluated its feasibility utility PET imaging cancer. could accumulate CXCR4/integrin positive BxPC3 tumors high concentration was much higher than...
Purpose Non-invasive techniques to monitor the survival and migration of transplanted stem cells in real-time is crucial for success cell therapy. The aim this study was explore multimodality molecular imaging with a triple-fused reporter gene [TGF; herpes simplex virus type 1 thymidine kinase (HSV1-tk), enhanced green fluorescence protein (eGFP), firefly luciferase (FLuc)] acute myocardial infarction rat models. Methods Rat established by ligating left anterior descending coronary artery. A...
Objective . To explore the diagnostic value of maximum standard uptake (SUVmax) from 18 F-FDG PET/CT images in enlarged mediastinal lymph nodes unknown etiology. Methods We performed a retrospective study patients with on scans. SUVmax and short axis long were recorded. These parameters compared among five commonest causes lymphadenopathy: lymphoma, metastatic disease, sarcoidosis, tuberculosis, lymphadenitis. Histopathologic diagnosis was recorded as final golden standard. Results A total...
The prognostic value of PET/CT for extranodal natural killer/T-cell lymphoma (ENKTL) patients is controversial. We sought to investigate the use pretreatment and interim in this disease.Sixty-five diagnosed with ENKTL who underwent (n = 53) and/or scans (after 2-4 cycles chemotherapy radiotherapy, n 33) were retrospectively enrolled. Interim images interpreted according Deauville 5-point scale. results assessed their predictive progression-free survival (PFS) overall (OS). Kaplan-Meier...
Parathyroid cysts are relatively uncommon lesions and often misdiagnosed. We evaluate our experience in the diagnosis of therapy to correct parathyroid cystic lesions.We retrospectively reviewed a series 32 patients with who were admitted department between July 2011 November 2016. Clinical pathological features patients, including age, gender, location, size, ultrasonography, histopathology, surgery, follow-up, analyzed.There 22 female 10 male participants median age 46.7 years old (27-76...
Abstract The human tyrosinase gene TYR is a multifunctional reporter with potential use in photoacoustic imaging (PAI), positron emission tomography (PET) and magnetic resonance (MRI). We sought to establish evaluate system using under the control of Tet-on expression (gene induced by doxycycline [Dox]) as multimodality agent. transfected into breast cancer cells (MDA-MB-231), naming resulting cell line 231-TYR. Using non-transfected MDA-MB-231 control, we verified successful 231-TYR after...