A5047479260- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Diagnosis and treatment of tuberculosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Microbial Natural Products and Biosynthesis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Response and Inflammation
- Infectious Diseases and Tuberculosis
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Bacterial Genetics and Biotechnology
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Bacterial biofilms and quorum sensing
- Pulmonary Hypertension Research and Treatments
- Cardiac tumors and thrombi
- Voice and Speech Disorders
- Occupational and environmental lung diseases
- Medical Imaging and Analysis
- Tuberous Sclerosis Complex Research
Huazhong University of Science and Technology
2024-2025
Zhongnan University of Economics and Law
2025
Qiqihar Medical University
2025
Eulji University Hospital
2025
Ministry of Education of the People's Republic of China
2025
Ohio University
2019-2024
Quanzhou Normal University
2024
Biotechnology Institute
2019-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Chinese PLA General Hospital
2024
Biodegradation using enzyme-based systems is a promising approach to minimize antibiotic loads in the environment. Aminoglycosides are refractory antibiotics that generally considered non-biodegradable. Here, we provide evidence kanamycin, common aminoglycoside antibiotic, can be degraded by an environmental bacterium through deglycosylation of its 4'-amino sugar. The unprecedented inactivation kanamycin initiated novel periplasmic dehydrogenase complex, which designated AquKGD, composed...
This study developed and tested a model linking independent self-construal to radical creativity by utilizing the framework of uniqueness theory. We administered time-lagged surveys 277 dyads employees their immediate supervisors. The results showed that had significant positive effect on creativity, while need for played mediating role in this relationship. Furthermore, an error-management climate positively moderated both relationship between uniqueness, indirect through uniqueness....
Renal dynamic scintigraphy is a crucial diagnostic tool for assessing renal function, yet unexpected findings can provide additional insights into extrarenal conditions. We report 2 rare cases of 99m Tc-DTPA uptake associated with adrenal tumors: one cortical carcinoma and pheochromocytoma. In both cases, significant tracer accumulation in the region was observed, highlighting an uncommon but noteworthy consideration. These emphasize importance including tumors differential diagnosis when...
Introduction: The early lung adenocarcinoma detection rate has increased with the development and application of low-dose computed tomography. However, overdiagnosis overtreatment are frequent. Here, we established a cytology grading system for adenomatous hyperplasia (AAH), in situ (AIS), minimally invasive (MIA) correlated tomography (CT) features ground-glass nodules (GGNs) to predict their biological behavior. Methods: We screened 166 GGNs pathological diagnoses AAH, AIS, MIA from 900th...
Summary Heat‐stable antifungal factor (HSAF) produced by Lysobacter enzymogenes is a potential lead compound for developing new antibiotics. Yet, how L. regulates the HSAF biosynthesis remains largely unknown. Here, we show that 4‐hydroxybenzoic acid (4‐HBA) serves as diffusible regulating biosynthesis. The of 4‐HBA involved an oxygenase, LenB2, and mutation lenB2 almost completely abolished production, leading to significantly impaired production. Introduction heterologous gene coding...
Lysobacter species are a group of environmental bacteria that emerging as new source antibiotics. One characteristic is intrinsic resistance to multiple antibiotics, which had not been studied. To understand the mechanism, we tested effect blocking two-component regulatory systems (TCSs) on antibiotic enzymogenes, prolific producer Upon treatment with LED209, an inhibitor widespread TCS QseC/QseB, L. enzymogenes produced large amount unknown metabolite was barely detectable in untreated...
Abstract Next generation sequencing ( NGS )‐based human leukocyte antigen HLA ) typing was used for ultra large‐scale genotyping of registry donors the China Marrow Donor Program CMDP ). More than 79,000 samples were subjected to at 4‐digit allelic level without ambiguities ‐A, ‐B, ‐C, DRB1 and DQB1 loci, with throughput up 2068 per lane in a HiSeq flow cell (eight lanes run), cost reduced by 95% compared that Sanger‐based typing. Two percent randomly selected quality control QC tested...
Diffuse panbronchiolitis (DPB), which is prevalent in Japan, known to be rare outside Japan. Although a case of diffuse second generation Korean was reported Japan 1986, no has been Korea. Recently we found 5 cases Korea, two histologically proven and three clinically radiologically suspected. All had the typical respiratory symptoms signs history chronic sinusitis. In suspected cases, high resolution computed tomography showed findings DPB other diseases such as pulmonary emphysema,...
The twitching motility of bacteria is closely related to environmental adaptability and pathogenic behaviors. Lysobacter a good genus in which study because the complex social activities distinct movement patterns its members. Regardless, mechanism that induces largely unknown. In this study, we found interspecies signal indole caused have irregular, random with significantly enhanced speed. Deletion qseC or qseB from two-component system for signaling perception resulted disappearance...
Four novel bioactive tetrahydroanthra-γ-pyrone compounds, shellmycin A–D (1–4), were isolated from the marine Streptomyces sp. shell-016 derived a shell sediment sample collected Binzhou Shell Dike Island and Wetland National Nature Reserve, China. The structures of these four compounds established by interpretation 1D 2D NMR HR-MS data, in which absolute configuration 1 was confirmed single crystal X-ray diffraction, compound 3 4 are pair stereoisomers. Compound 1–4 exhibited cytotoxic...
Endobronchial tuberculosis is a serious disease which frequently complicated with bronchial stenosis, and it may simulate asthma or bronchogenic carcinoma.We have analyzed the clinical characteristics of endobronchial in 166 patients, we introduce new classification tuberculosis.Endobronchial classified into seven subtypes as stenotic type fibrosis, without actively caseating type, tumorous 비cerative granular nonspecific bronchitic according to bronchoscopic findings.Actively caseaing...
This study sought to evaluate the differential effects of bladder distention on point A-based (AICBT) and three-dimensional conformal intracavitary brachytherapy (3D-ICBT) planning for cervical cancer. Two sets CT scans were obtained ten patients effect distention. After first scan, with an empty bladder, a second set was filled. The clinical target volume (CTV), rectum, small bowel delineated each image set. AICBT 3D-ICBT plans generated, we compared different techniques respect dose...
Alveolar macrophages exist in the lung airspaces, and their differentiation function are considerably regulated by microenvironment. In this study, we examine important role of resident neutrophil/IL-23/granulocyte/macrophage colony-stimulating factor (GM-CSF) axis development preferential phenotype alveolar under physiological conditions. Using CD18-deficient (CD18(-/-) ) mice, show a correlation between increased granulopoiesis enhanced macrophage an IL-23- GM-CSF-dependent manner. The...