A5103215609- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Psoriasis: Treatment and Pathogenesis
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Inflammasome and immune disorders
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Esophageal Cancer Research and Treatment
- Trauma Management and Diagnosis
- Circular RNAs in diseases
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Respiratory viral infections research
Air Force Medical University
2016-2025
First Hospital of Jilin University
2010-2025
Jilin University
2010-2025
Tang Du Hospital
2017-2024
Sun Yat-sen University
2023-2024
Sun Yat-sen University Cancer Center
2023-2024
Chongqing University
2024
Southwest University
2024
Hebei North University
2008-2024
Yahoo (United Kingdom)
2023
Abstract The cell ecology and spatial niche implicated in the dynamic sequential process of lung adenocarcinoma (LUAD) from situ (AIS) to minimally invasive (MIA) subsequent (IAC) have not yet been elucidated. Here, we performed an integrative analysis single-cell RNA sequencing (scRNA-seq) transcriptomics (ST) characterize atlas invasion trajectory LUAD. We found that UBE2C + cancer subpopulation constantly increased during LUAD with remarkable elevation IAC, its distribution was peripheral...
The benefit of neoadjuvant camrelizumab plus chemotherapy for resectable stage IIIA or IIIB non-small cell lung cancer (NSCLC) remains unknown.To assess the efficacy and safety vs alone patients with NSCLC.In this randomized phase 2 clinical trial conducted at hospitals in China, aged 18 to 70 years (T3N2) NSCLC were enrolled between April 7, 2020, January 12, 2022.Patients randomly assigned receive 3 cycles (200 mg) (nab-paclitaxel, 130 mg/m2, platinum [cisplatin, 75 mg/m2; carboplatin,...
Vascular endothelial cells (ECs) are increasingly recognized as active players in intercellular crosstalk more than passive linings of a conduit for nutrition delivery. Yet, their functional roles and heterogeneity skin remain uncharacterized. We have used single-cell RNA sequencing (scRNA-seq) profiling strategy to investigate the tissue-specific features intra-tissue dermal ECs at level. Methods: Skin tissues collected from 10 donors were subjected scRNA-seq. Human EC atlas over 23,000...
Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease that can be life-threatening. Gene mutations are found in some cases, but its immune pathogenesis largely unknown. Here, we observed the neutrophil:lymphocyte ratio patients with GPP was higher than healthy controls decreased after effective treatment. Neutrophils isolated from induced expressions of genes including IL-1β, IL-36G, IL-18, TNF-α, C-X-C motif chemokine ligands keratinocytes normal neutrophils...
Abstract Transcription factor AP-2α (TFAP2A) was previously regarded as a critical regulator during embryonic development, and its mediation in carcinogenesis has received intensive attention recently. However, role lung adenocarcinoma (LUAD) not been fully elucidated. Here, we tried to investigate TFAP2A expression profiling, clinical significance, biological function molecular underpinnings LUAD. We proved LUAD possessed universal high expression, indicating pervasively poorer prognosis...
Diabetic nephropathy (DN) is a microangiopathic disease characterized by excessive urinary albumin excretion, which occurs in 30% of patients with diabetes mellitus. It the second leading cause end-stage renal diseases China. Nuclear factor-kappa B (NF-κB) reported to be closely correlated inflammation underlying diabetes-associated damage. Crocin, plant-derived compound, has antioxidant properties that may inhibit NF-κB.In present study, we used conditionally immortalized mouse podocyte...
Psoriasis is characterized by keratinocyte hyperproliferation. While significant progress has been made in understanding the molecular mechanism regulating proliferation of keratinocytes, little known about epigenetic factors that control this process. EZH2 and mediated trimethylation histone H3 lysine 27 (H3K27me3) was previously shown ectopically expressed carcinoma proliferation, thereby we sought to clarify role EZH2-H3K27me3 psoriatic keratinocyte. Interestingly, found H3K27me3 were...
Abstract Background Exosomes are known to transmit microRNAs (miRNAs) affect cancer progression, while the role of M2 macrophages-derived exosomes (M2 exosomes) conveying miR-501-3p in lung (LC) remains unknown. We aim explore exosomal LC development via targeting WD repeat domain 82 (WDR82). Methods Lung tissue and normal specimens were collected, which tumor-associated macrophages (TAM) measured by immunohistochemistry. induced treated with altered miR-501-3p, then extracted identified....
The global spread of the novel coronavirus disease 2019, caused by SARS-CoV-2 virus, impacts individuals all age groups, including lactating women and children. Concerns have been raised regarding potential transmission from mother to child, following discovery RNA in human milk. Therefore, this study aims investigate whether Omicron variants are transmitted through This was conducted between March May 2022 at Children's Medical Center, First Hospital Jilin University, Lequn Branch. Fourteen...
The refinement of risk stratification in lung adenocarcinoma (LUAD) plays a pivotal role advancing precision medicine; however, the current staging classification falls short comprehensiveness, particularly case stage IA patients. We aimed to molecularly stratify LUAD patients especially for IA. analysed tumour heterogeneity and identified highly proliferating cancer cells (HPCs) by performing single-cell RNA sequencing (scRNA-seq) analysis, immunohistochemical (IHC) staining using tissue...
Abstract Psoriasis is a common chronic inflammatory skin disease characterized by epidermal hyperplasia and dermal inflammation. Keratinocyte activation known to play critical role in psoriasis, but the underlying mechanism remains unclear. Interferon-inducible protein 16 (IFI16), an innate immune system sensor, reported affect keratinocyte function. We therefore hypothesized that IFI16 promotes psoriasis modulating activation. In present study, we cinfirmed was overexpressed keratinocytes...
Abstract Objective Mutations in driver genes contribute to the development and progression of lung adenocarcinoma (LUAD). However, dynamic evolutionary process from situ (AIS) minimally invasive (MIA) eventually (IAC), role is currently unclear. This study aimed analyse gene status LUAD preneoplasia IAC. Methods Patients with who underwent surgery our centre March 2015 December 2019 were retrospectively analysed, patients tumour sizes ≤3.0 cm pN0 included final analysis. The mutation common...
This study aimed to investigate the prospects of using chemotherapy in combination with atezolizumab neoadjuvant or conversion treatment small cell lung cancer (SCLC).Prior surgery, untreated patients limited-stage SCLC received three cycles combined etoposide and platinum. The primary endpoint trial was pathological complete response (pCR) per-protocol (PP) cohort. In addition, safety assessed based on treatment-related adverse events (AEs) postoperative complications.Overall, 13 17...
Abstract Tumor‐associated macrophages (TAMs) greatly contribute to immune checkpoint inhibitor (ICI) resistance of cancer. However, its underlying mechanisms and whether TAMs can be promising targets overcome ICI remain unveiled. Through integrative analysis multiomics data single‐cell RNA‐seq (iMOS) in lung adenocarcinoma (LUAD), lymphotoxin β receptor ( LTBR ) is identified as a potential TAMs, whose high expression, duplication, low methylation are correlated with unfavorable prognosis....
Abstract Extracorporeal Membrane Oxygenation (ECMO) has become an increasingly important technique for patients with respiratory or cardiac failure a variety of causes. In addition, there are many reports about the use ECMO in surgical operation on neonates and children tracheal obstruction. this report we present case adult patient who underwent carinal resection reconstruction after left pneumonectomy assistance successfully. To our knowledge, is first its kind to pneumonectomy. report,...
Lung cancer is the leading cause of mortality in both men and women, with dismal survival rates due to late-stage diagnoses a lack efficacious therapies. The new treatment options completely novel mechanism therapeutic activity are needed for lung improve patient outcome. present study was aimed at testing efficacy recombinant adenovirus H101 as an oncolytic agent killing human cell lines vitro vivo. We assessed coxsackievirus receptor (CAR) expression on by RT-PCR immunocytochemistry...
KIAA1199 has been identified as an oncogene in many cancers. Here, we collected 153 cases of nonsmall cell lung cancer (NSCLC) tissues to investigate the relationships between protein and clinical factors.Immunohistochemistry (IHC) staining was used detect expression KIAA1199. Follow-up included blood analysis, chest X-ray, ultrasound examination, computed tomography carried out every 3 months for first 2 years at 6-month intervals thereafter during follow-up period (3 years). Kaplan-Meier...