A5100733696- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Microtubule and mitosis dynamics
- Protein Degradation and Inhibitors
- Machine Learning in Healthcare
- Histone Deacetylase Inhibitors Research
- Advanced Photocatalysis Techniques
- Ferroptosis and cancer prognosis
- Carbon dioxide utilization in catalysis
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Viral-associated cancers and disorders
- Meningioma and schwannoma management
- Genital Health and Disease
Hainan University
2025
Xiamen University
2023-2024
Sun Yat-sen University
2013-2024
Sun Yat-sen University Cancer Center
2013-2024
University of Massachusetts Boston
2021-2024
Jiangnan University
2024
Shanxi Medical University
2023-2024
Xinjiang Medical University
2024
Tumor Hospital of Xinjiang Medical University
2024
Annoroad Gene Technology (China)
2024
Abstract Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that HIF-1α anti-sense lncRNA, HIFAL, essential for maintaining and enhancing HIF-1α-mediated transactivation glycolysis. Mechanistically, HIFAL recruits prolyl hydroxylase 3 (PHD3) to pyruvate kinase 2 (PKM2) induce its hydroxylation introduces the PKM2/PHD3 complex into nucleus via binding with heterogeneous nuclear ribonucleoprotein F (hnRNPF) enhance transactivation....
Abstract Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes progress and determines the outcome of therapeutic response. Here, we comprehensively characterized transcriptomes 34,037 single cells obtained from 12 treatment‐naïve patients with colorectal cancer. Our comprehensive evaluation revealed attenuated B‐cell antigen presentation, distinct regulatory T‐cell clusters different origin novel polyfunctional associated macrophages...
Bladder cancer treatment remains a major clinical challenge due to therapy resistance and high recurrence rate. Profiling intratumor heterogeneity can reveal the molecular mechanism of bladder recurrence.Here, we performed single-cell RNA sequencing Assay for Transposase-Accessible Chromatin using (ATAC-seq) on tumors from 13 patients with low risk, recurrent cancer.Our study generated comprehensive cancer-cell atlas consisting 54,971 single cells identified distinct cell subpopulations. We...
Traditional EZH2 inhibitors are developed to suppress the enzymatic methylation activity, and they may have therapeutic limitations due nonenzymatic functions of in cancer development. Here, we report proteolysis-target chimera (PROTAC)-based degraders target whole lymphoma. Two series were designed synthesized hijack E3 ligase systems containing either von Hippel–Lindau (VHL) or cereblon (CRBN), some VHL-based compounds able mediate degradation. best degraders, YM181 YM281, induced robust...
The importance of trained immunity in antitumor has been increasingly recognized, but the underlying metabolic regulation mechanisms remain incompletely understood. In this study, we find that squalene epoxidase (SQLE), a key enzyme cholesterol synthesis, is required for β-glucan-induced macrophages and ensuing activity. Unexpectedly, shunt pathway, not classical synthesis catalyzed by SQLE, induction. Specifically, 24(S),25-epoxycholesterol (24(S),25-EC), pathway metabolite, activates liver...
Abstract Background Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little known about how SEs facilitate tumour suppression. Individuals Down syndrome exhibit remarkably reduced incidence of breast cancer (BC), moving the search for tumor suppressor genes on human chromosome 21 (HSA21). In this study, we aim to identify and explore potential mechanisms by are established RCAN1.4 HSA21 BC. Methods silico analysis...
Abstract Triple‐negative breast cancer (TNBC) has a relatively poor outcome. Acquired chemoresistance is major clinical challenge for TNBC patients. Previously, we reported that kinase‐dead Aurora kinase A (Aurora‐A) could effectively transactivate the FOXM1 promoter. Here, demonstrate an additional pathway through which Aurora‐A stabilizes by attenuating its ubiquitin in TNBC. Specifically, late M phase and early G1 of cell cycle, promotes proliferation cells. Knock‐down significantly...
Synthesis of formate from hydrogenation carbon dioxide (CO2 ) is an atom-economic reaction but confronted with challenges in developing high-performance non-precious metal catalysts for application the process. Herein, we report a highly durable edge-rich molybdenum disulfide (MoS2 catalyst CO2 to at 200 °C, which delivers high selectivity over 99 % superior turnover frequency 780.7 h-1 surpassing those previously reported catalysts. Multiple experimental characterization techniques combined...
Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness establish the hierarchical architectures remains elusive. Here, pan-cancer transcriptomic screening for 10852 samples of 33 TCGA types reveals that cAMP-responsive element (CRE) transcription factors are convergent activators stemness. Deconvolution profiles, specification markers and illustration norepinephrine dynamics uncover bond...
Abstract FOXA family proteins act as pioneer factors by remodeling compact chromatin structures. FOXA1 is crucial for the binding of androgen receptor (AR) in both normal prostate epithelial cells and luminal subtype cancer (PCa). Recent studies have highlighted emergence FOXA2 an adaptive response to AR signaling inhibition treatments. However, role transition regulating lineage plasticity remains unclear. Our study demonstrates that binds distinct classes developmental enhancers multiple...
Abstract The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk fragility fractures. However, the specific mechanisms HFD-induced are not fully understood. Our study shows that exposure HFD induces premature senescence in bone marrow mesenchymal stem cells (BMSCs), diminishing their proliferation osteogenic capability, thereby contributes osteoporosis. Transcriptomic chromatin accessibility analyses revealed decreased vitamin D receptor (VDR)-binding...
The human microRNA cluster MC-let-7a-1∼let-7d, with three members let-7a-1, let-7f-1, and let-7d, is an important of the let-7 family. These microRNAs play critical roles in regulating development carcinogenesis. Therefore, precise control MC-let-7a-1∼let-7d level for cellular functions. In this study, we first showed that expression these was significantly reduced hepatocellular carcinoma HepG2 cells as compared immortalized liver L02 cells. We demonstrated encoded by a single polycistronic...
Abstract AURKA is a potential kinase target in various malignancies. The kinase‐independent oncogenic functions partially disclose the inadequate efficacy of inhibitor Phase III clinical trial. Simultaneously targeting catalytic and noncatalytic may be feasible approach. Here, set proteolysis chimeras (PROTACs) are developed. CRBN‐based dAurA383 preferentially degrades highly abundant mitotic AURKA, while cIAP‐based dAurA450 lowly interphase acute myeloid leukemia (AML) cells. proteomic...
The androgen receptor (AR) plays a pivotal role in driving prostate cancer (PCa) development. However, when stimulated by high levels of androgens, AR can also function as tumor suppressor PCa cells. While the high-dose testosterone (high-T) treatment is currently being tested clinical trials castration-resistant (CRPC), there still pressing need to fully understand underlying mechanism and thus develop strategies exploit this tumor-suppressive activity AR. In study, we demonstrate that...