A5100614795- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Genetic and phenotypic traits in livestock
- Circular RNAs in diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Amino Acid Enzymes and Metabolism
- Renal and related cancers
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Genetic Mapping and Diversity in Plants and Animals
- TGF-β signaling in diseases
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- DNA and Nucleic Acid Chemistry
- Genomics, phytochemicals, and oxidative stress
- Tryptophan and brain disorders
Guiyang Medical University
2019-2025
Xuzhou Medical College
2023-2025
Tongji Hospital
2017-2024
Third Affiliated Hospital of Sun Yat-sen University
2014-2024
Sun Yat-sen University
2014-2024
Huazhong University of Science and Technology
2017-2024
Nanchang University
2021-2024
State Key Laboratory of Medicinal Chemical Biology
2023-2024
Anhui Medical University
2022-2024
Fujian Agriculture and Forestry University
2024
Significance Macrophages maintain homeostatic proliferation in the presence of mitogens whereas encounters with invading microorganisms inhibit and engage a rapid proinflammatory response. Such cell fate change requires an extensive reprogramming metabolism, regulatory mechanisms behind this remain unknown. We found that myelocytomatosis viral oncogen (Myc) plays major role regulating proliferation-associated metabolic programs. However, stimuli suppress Myc hypoxia-inducible factor alpha...
Abstract Ferroptosis is a newly identified iron-dependent form of death that becoming increasingly recognized as promising avenue for cancer therapy. N6-methyladenosine (m 6 A) the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, crucial role m A regulating ferroptosis during colorectal (CRC) tumorigenesis remains elusive. Herein, we find increased ferroptotic cell and correlates with decreased demethylase fat mass obesity-associated protein...
Lung cancer is the leading cause of death worldwide. However, molecular mechanisms underlying lung development have not been fully understood. The functions histone deacetylases (HDACs), a class total eighteen proteins (HDAC1-11 and SIRT1-7 in mammals) that deacetylate histones non-histone proteins, cancers are largely unknown.Hdac7 +/-/K-Ras mice HDAC7-depleted human cell lines were used as models for studying function Hdac7 gene cancer. Kaplan-Meier survival analysis was performed to...
This work demonstrates the significant fluorescence enhancement of thioflavin T (ThT) when binding to G-quadruplexes possessing hybrid structures by using UV-vis absorption spectra, and Tm experiments confirm events. ThT does not disturb native G-quadruplex preformed in Na(+) K(+) solutions. The is caused rotation restriction benzothiazole (BZT) dimethylaminobenzene (DMAB) rings excited state upon its binding. molecular rotor mechanism as a means confirmed nonrotor analogue ThT....
Effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain growth, proliferation, and cytokine production. Epigenetic control genome also governs cell transcriptome lineage commitment maintenance. Cellular programs interact with epigenetic regulation by providing substrates for covalent modifications chromatin. By using complementary genetic, epigenetic, approaches, we revealed that tricarboxylic acid (TCA) cycle flux fueled biosynthetic...
Abstract Background Abnormal microglial polarization phenotypes contribute to the pathogenesis of Alzheimer’s disease (AD). Circular RNAs (circRNAs) have garnered increasing attention due their significant roles in human diseases. Although research has demonstrated differential expression circRNAs AD, specific functions AD remain largely unexplored. Methods CircRNA microarray was performed identify differentially expressed hippocampus APP/PS1 and WT mice. The stability circAPP assessed via...
Polyamine homeostasis determines T cell function.
Single nucleotide polymorphism (SNP) is a common form of genetic variation and popularly exists in maize genome. An Illumina GoldenGate assay with 1 536 SNP markers was used to genotype inbred lines identified the functional variations underlying drought tolerance by association analysis. Across 80 lines, 006 polymorphic SNPs (65.5% total) good call quality were estimate pattern diversity, population structure, familial relatedness. The analysis showed best number fixed subgroups six, which...
Abstract AURKA is a potential kinase target in various malignancies. The kinase‐independent oncogenic functions partially disclose the inadequate efficacy of inhibitor Phase III clinical trial. Simultaneously targeting catalytic and noncatalytic may be feasible approach. Here, set proteolysis chimeras (PROTACs) are developed. CRBN‐based dAurA383 preferentially degrades highly abundant mitotic AURKA, while cIAP‐based dAurA450 lowly interphase acute myeloid leukemia (AML) cells. proteomic...
Our previous studies have revealed that the protective effect of an enriched environment (EE) may be linked with astrocyte proliferation and angiogenesis. However, relationship between astrocytes angiogenesis under EE conditions still requires further study. The current research examined neuroprotective effects on in astrocytic interleukin-17A (IL-17A)-dependent manner following cerebral ischemia/reperfusion (I/R) injury.A rat model ischemic stroke based middle artery occlusion (MCAO) for...
Impaired wound healing and ulcer complications are major causes of morbidity in patients with diabetes. is associated increased inflammation poor angiogenesis diabetes patients. Here, we demonstrate that topical administration a secreted recombinant protein (Meteorin-like [Metrnl]) accelerates epithelialization mice. We observed significant increase Metrnl expression during physiological healing; however, its remained low diabetic healing. Functionally, the significantly accelerated closure...
Abstract Background The roles of mitochondria in energy metabolism, the generation ROS, aging, and initiation apoptosis have implicated their importance tumorigenesis. In this study we aim to establish mutation spectrum understand role somatic mtDNA mutations esophageal cancer. Methods entire mitochondrial genome was screened for 20 pairs (18 squamous cell carcinomas, one adenosquamous carcinoma adenocarcinoma) tumor/surrounding normal tissue cancers, using temporal temperature gradient gel...
// Wen Zhang 1, * , Li Bao 3, 9, 10, Shaoxing Yang 6, Zhaoyang Qian Mei Dong 4, Liyuan Yin 2, 19 Zhao 7 Keli Ge 1 Zhenling Deng Jing 5 Fei Qi 8 Zhongxue An 3 Yuan Yu Qingbo Wang Renhua Wu Fan Lianfeng 16 Xiping Chen 17 Yingjian Na Lin Feng 2 Lingling liu Yujie Zhu Tiancheng Qin Shuren Youhui Xiuqing 11, 12 Jian 13 Xin Yi Liqun Zou Hong-Wu 18 Henrik J. Ditzel 14 Hongjun Gao 6 Kaitai Binlei Liu 15, Shujun Cheng Department of Immunology, Cancer Hospital, Chinese Academy Medical Sciences and...
AIM2, a cytosolic DNA sensor, plays an important role during infection caused by pathogens with double-stranded DNA; however, its in human cytomegalovirus (HCMV) remains unclear. Previously, we showed increase AIM2 protein levels the early stage of HCMV and decrease 24 h post infection. Because has developed variety strategies to evade host immunity, speculated that this decline might be attributed viral immune escape mechanism. The tegument pUL83 is evasion several studies have reported...
XB130, a classical adaptor protein, exerts critical role in diverse cellular processes. Aberrant expression of XB130 is closely associated with tumorigenesis and aggressiveness. However, the mechanisms governing its regulation remain poorly understood. Heterogeneous nuclear ribonucleoprotein C (hnRNPC), as an RNA-binding known to modulate multiple aspects RNA metabolism has been implicated pathogenesis various cancers. We have previously discovered that hnRNPC one candidate proteins interact...
Abstract Background Alveolar rhabdomyosarcoma (ARMS) has a high propensity to metastasize, leading its aggressiveness and poor survival rate among those with the disease. More than 80% of aggressive ARMSs harbor PAX3-FKHR fusion transcription factor, which regulates cell migration promotes metastasis, most likely by regulating protein’s transcriptional targets. Therefore, identifying druggable targets that are also downstream effectors PAX3-FKHR–mediated metastasis may lead novel therapeutic...
The major cause of death among pulmonary hypertension patients is right heart failure, but the biology not well understood. Previous studies showed that mechanisms activation GATA4, a regulator cardiac hypertrophy, in response to pressure overload are different between left and ventricles. In ventricle, aortic constriction triggers GATA4 via posttranslational modifications without influencing expression, while artery banding enhances expression ventricle. We found can also be increased...
Thioflavin T (ThT) has been widely utilized as a fluorescent marker for amyloid fibrils. However, the use of ThT an efficient reporter specific DNA structure still remains in question. Here, we report that fluorescence intensity is obviously enhancement when it binds to ds-DNAs which contain cavity structures such abasic site, gap site or mismatch site. Such cannot be achieved without these structures. The cavities provide appropriate spaces accommodate and allow occurrence some...
Absent in melanoma 2 (AIM2) inflammasome is a multiprotein complex which plays pivotal role the host immune response to multiple pathogens. The of AIM2 human cytomegalovirus (HCMV) infection poorly studied. Thus, using small inference RNA (siRNA) approach and THP‐1 derived macrophage cells infected with HCMV AD169 strain, we investigated impact on AIM2‐mediated molecular events. Compared wild‐type cells, AIM2‐defiecient macrophages showed limited ability activate caspase‐1, process IL‐1β,...