A5100414438- Analytical Chemistry and Chromatography
- RNA modifications and cancer
- Mass Spectrometry Techniques and Applications
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Asymmetric Synthesis and Catalysis
- Soybean genetics and cultivation
- Neurobiology and Insect Physiology Research
- Glycosylation and Glycoproteins Research
- Synthesis and Biological Evaluation
- Phagocytosis and Immune Regulation
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Immune cells in cancer
- Membrane-based Ion Separation Techniques
- Insect and Arachnid Ecology and Behavior
- Immune Cell Function and Interaction
- Chemical Synthesis and Reactions
- Cyclopropane Reaction Mechanisms
- Membrane Separation Technologies
- Carbohydrate Chemistry and Synthesis
- RNA Research and Splicing
- Microfluidic and Capillary Electrophoresis Applications
Beijing National Laboratory for Molecular Sciences
2009-2025
Peking University
2012-2025
Chongqing University
2020-2025
Chinese Academy of Sciences
2007-2025
Shanghai Institute of Materia Medica
2025
Guiyang Medical University
2023-2025
Shandong University
2022-2025
Harbin Medical University
2021-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Shanghai University of Traditional Chinese Medicine
2025
Microelectrodes enable localized electrical stimulation and recording, they have revolutionized our understanding of the spatiotemporal dynamics systems that generate or respond to signals. However, such comprehensive rely on molecular signals—e.g., chemical communication in multicellular neural, developmental, immune systems—remains elusive because inability deliver, capture, interpret complex information. To overcome this challenge, we developed “chemistrode,” a plug-based microfluidic...
The quality of tissue imaging by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) depends on the effectiveness matrix deposition, especially for lipids that may dissolve in solvent used application. This article describes use an oscillating capillary nebulizer (OCN) to spray small droplets aerosol onto sample surface improved homogeneity, reduced crystal size, and controlled effects. system was then applied analysis histological slices brains from mice with homozygous...
Abstract The development of osteoporosis is often accompanied by autophagy disturbance, which also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs). However, the underlying molecular mechanisms are still not fully understood. Methyltransferase-like 14 (METTL14) main enzyme for N6-methyladenosine (m6A), most prevalent internal modification in mammalian mRNAs, and it has been implicated many bioprocesses. Herein, we demonstrate that METTL14 plays a critical role...
Abstract Massive intra-articular infiltration of proinflammatory macrophages is a prominent feature rheumatoid arthritis (RA) lesions, which are thought to underlie articular immune dysfunction, severe synovitis and ultimately joint erosion. Here we report an efferocytosis-informed nanoimitator (EINI) for in situ targeted reprogramming synovial inflammatory (SIMs) that thwarts their autoimmune attack reestablishes homeostasis, mitigates RA. The EINI consists drug-based core with oxidative...
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration Alzheimer's disease (AD). The aggregation hyperphosphorylated into neurofibrillary tangles is also hallmark brain lesion AD. Tau phosphorylation regulated by kinases, phosphatases, and O-GlcNAcylation, posttranslational modification proteins on the serine or threonine residues with β-N-acetylglucosamine (GlcNAc). O-GlcNAcylation dynamically O-GlcNAc transferase, enzyme catalyzing...
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal O-GlcNAc groups to from are catalyzed O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) β-N-acetylglucosaminidase (O-GlcNAcase, OGA), respectively. often modulates protein phosphorylation regulates several cellular signaling functions, especially in the brain. However, its developmental regulation not well known. Here,...
Selecting a suitable site to deposit their eggs is an important reproductive need of Drosophila females. Although choosiness toward egg-laying sites well documented, the specific neural mechanism that activates females' search for attractive not known. Here, we show distention and contraction internal tract triggered by egg delivery through plays critical role in activating such search. We found females start exhibit acetic acid (AA) attraction prior depositing each but no when they are...
Diabetes is a chronic metabolic disorder disease characterized by high blood glucose levels and has become one of the most serious threats to human health. In recent decades, number insulin delivery systems, including bulk gels, nanogels, polymeric micelles, have been developed for treatment diabetes. Herein, kind H2O2 dual-responsive nanogel was designed enhanced glucose-responsive delivery. The nanogels composed poly(ethylene glycol) poly(cyclic phenylboronic ester) (glucose dual-sensitive...
Electrochemically driven, Cp*Ir(III)-catalyzed regioselective annulative couplings of benzoic acids with alkynes have been established herein. The combination iridium catalyst and electricity not only circumvents the need for stoichiometric amount chemical oxidant, but also ensures broad reaction compatibility a wide array sterically electronically diverse substrates. This electrochemical approach represents sustainable strategy as an ideal alternative supplement to oxidative annulations...
N,N'-Bis(n-octyl)-2,3,6,7-tetrabromonaphthalene diimide (TBNDI) was synthesized by a new imidization reaction and characterized HRMS, (1)H NMR, (13)C elemental analyses, FT-IR, UV-vis, single-crystal X-ray analysis. The TBNDIs are the key precursors for synthesis of core-tetrasubstituted-naphthalene diimides.
Abstract The synthesis, characterization, and field‐effect transistor (FET) properties of a new class thieno[3,2‐b]thieno[2′,3′:4,5]thieno[2,3‐d]thiophene derivatives are described. optical spectra their films show the presence stronger interactions between molecules in solid state. Thermal analyses reveal that three materials thermally stable have no phase transitions at low temperature. crystal structures determined, π‐stacked intermolecular S···S contacts. These organic exhibit p‐type FET...
As a key copper homeostasis-related molecule, lipoyltransferase 1 (LIPT1) is an essential enzyme for the activation of mitochondrial 2-ketoacid dehydrogenase, participating in fatty acylation. However, biological significances LIPT1 pan-cancer are unclear. Here, we comprehensively analyzed functional characteristics human cancers and its roles immune response. We found that was down-regulated some cancers. And overexpression associated with favorable prognosis these patients, such as breast...
C1GALT1 plays a pivotal role in colorectal cancer (CRC) development and progression through its involvement various molecular mechanisms. This enzyme is central to the O-glycosylation process, producing tumor-associated carbohydrate antigens (TACA) like Tn sTn, which are linked metastasis poor prognosis. The interaction between core 3 synthase crucial for synthesis of O-glycans, essential gastrointestinal health mucosal barrier integrity. Aberrations this pathway can lead CRC development....
G-triplexes are G-rich oligonucleotides composed of three G-tracts and have absorbed much attention due to their potential biological functions attractive performance in biosensing. Through the optimization loop compositions, DNA lengths, 5'-flanking bases sequences, a new stable G-triplex sequence with 14 (G3-F15) was discovered dramatically activate fluorescence Thioflavin T (ThT), water-soluble fluorogenic dye. The enhancement ThT after binding G3-F15 reached 3200 times, which strongest...
A series of fused thiophenes composed alpha-oligothiophene units as building blocks, end-capped with either styrene or 1-pentyl-4-vinylbenzene groups, has been synthesized through Stille coupling reactions. The compounds have fully characterized by means (1)H NMR spectrometry, high-resolution mass and elemental analysis. molecules present a trans-trans configuration between their double bonds, which verified confirmed Fourier-transform infrared spectroscopy single-crystal X-ray diffraction...
A novel and efficient method for the construction of α-(1,3-dithiolan-2-ylidene) δ-lactam δ-lactone rings has been developed. It involves regiospecific 6-endo-annulation in situ generated 2-(1,3-dithiolan-2-ylidene)-3,4-dienamides/acids from dehydrative coupling α-oxo ketene dithioacetals with tertiary propargyl alcohols promoted by BF3·Et2O. range δ-lactams δ-lactones are obtained good to high yields. In addition, indenes prepared using α-acetyl dithioacetal as precursor.
Accurate genotyping is important for genetic testing. Sanger sequencing-based typing the gold standard genotyping, but it has been underused, due to its high cost and low throughput. In contrast, short-read sequencing provides inexpensive high-throughput sequencing, holding great promise reaching goal of cost-effective genotyping. However, length paucity appropriate methods, pose a major challenge. Here, we present RCHSBT—reliable, sequence based pipeline—which takes short reads as input,...
The liver X receptor (LXR) agonist T317 reduces atherosclerosis but induces fatty liver. Metformin activates energy metabolism by activating AMPKα. In this study, we determined if interactions between metformin and could inhibit without activation of hepatic lipogenesis.Apolipoprotein E-deficient mice were treated with T317, or both agents, in a high-fat diet for 16 weeks. Then, samples aorta, liver, macrophage serum collected to determine atherosclerotic lesions, lipid profiles expression...