A5065974305- Redox biology and oxidative stress
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Sulfur Compounds in Biology
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- Multiple Sclerosis Research Studies
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Light effects on plants
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- T-cell and B-cell Immunology
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Psoriasis: Treatment and Pathogenesis
- Genomics, phytochemicals, and oxidative stress
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
University of South China
2015-2023
Nationwide Children's Hospital
2016-2018
The Ohio State University
2018
Tokushima University
2012
Significance Macrophages maintain homeostatic proliferation in the presence of mitogens whereas encounters with invading microorganisms inhibit and engage a rapid proinflammatory response. Such cell fate change requires an extensive reprogramming metabolism, regulatory mechanisms behind this remain unknown. We found that myelocytomatosis viral oncogen (Myc) plays major role regulating proliferation-associated metabolic programs. However, stimuli suppress Myc hypoxia-inducible factor alpha...
Upon antigen stimulation, T lymphocytes undergo dramatic changes in metabolism to fulfill the bioenergetic, biosynthetic and redox demands of proliferation differentiation. Glutathione (GSH) plays an essential role controlling balance cell fate. While GSH can be recycled from disulfide (GSSG), inhibition this recycling pathway does not impact content murine By contrast, de novo synthesis GSH, by deleting either catalytic (Gclc) or modifier (Gclm) subunit glutamate-cysteine ligase (Gcl),...
Abstract Heightened aerobic glycolysis and glutaminolysis are characteristic metabolic phenotypes in cancer cells. Neuroblastoma (NBL), a devastating pediatric cancer, is featured by frequent genomic amplification of MYCN, member the Myc oncogene family that primarily expressed early stage embryonic development required for neural crest development. Here we report an enriched gene signature associated with MYCN children NBL. The partial knockdown suppresses NBL Conversely, forced...
The interplay of CD4(+) and CD8(+) T cells targeting autoantigens is responsible for the progression a number autoimmune diseases, including type 1 diabetes mellitus (T1D). Understanding molecular mechanisms that regulate cell activation crucial designing effective therapies diseases. We probed panel Abs with cell-modulating activity identified mAb specific H chain CD98 (CD98hc) was able to suppress proliferation. anti-CD98hc also inhibited Ag-specific proliferation acquisition effector...
Photoreactivation is an error-free mechanism of DNA repair, utilized by prokaryotes and most eukaryotes catalyzed specific enzymes called photolyases. has been reported in Vibrio parahaemolyticus WP28; however, information on photolyases V. (V.p) strains not reported. This study examined the photoreactivation V.p RIMD2210633. The photolyase responsible for repairing cyclobutane pyrimidine dimer (CPD) was identified, corresponding gene determined as VPA1471. protein overexpressed Escherichia...