A5100447740- Cancer Cells and Metastasis
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Mechanisms of cancer metastasis
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Parkinson's Disease Mechanisms and Treatments
- Lung Cancer Research Studies
- Neurological disorders and treatments
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Cytokine Signaling Pathways and Interactions
- Adenosine and Purinergic Signaling
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Amyotrophic Lateral Sclerosis Research
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- Genomics, phytochemicals, and oxidative stress
- Liver physiology and pathology
Yunnan University
2025
University of Science and Technology of China
2025
China Medical University
2025
Nationwide Children's Hospital
2014-2024
The Ohio State University
2018-2024
Chinese Institute for Brain Research
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Anhui Medical University
2021-2024
Chongqing Medical University
2024
West China Hospital of Sichuan University
2020-2024
T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector must adapt fluctuations in environmental nutrient levels at sites of infection inflammation. Here, we show that can utilize inosine, as an alternative substrate, support cell growth function the absence glucose vitro. metabolize inosine into hypoxanthine phosphorylated ribose by purine nucleoside phosphorylase. We demonstrate subunit...
Significance Macrophages maintain homeostatic proliferation in the presence of mitogens whereas encounters with invading microorganisms inhibit and engage a rapid proinflammatory response. Such cell fate change requires an extensive reprogramming metabolism, regulatory mechanisms behind this remain unknown. We found that myelocytomatosis viral oncogen (Myc) plays major role regulating proliferation-associated metabolic programs. However, stimuli suppress Myc hypoxia-inducible factor alpha...
Upon antigen stimulation, T lymphocytes undergo dramatic changes in metabolism to fulfill the bioenergetic, biosynthetic and redox demands of proliferation differentiation. Glutathione (GSH) plays an essential role controlling balance cell fate. While GSH can be recycled from disulfide (GSSG), inhibition this recycling pathway does not impact content murine By contrast, de novo synthesis GSH, by deleting either catalytic (Gclc) or modifier (Gclm) subunit glutamate-cysteine ligase (Gcl),...
Robust and effective T cell immune surveillance cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth cytokine production. Here, we show that asparagine (Asn) restriction on CD8
Cancer stem cells (CSC) are thought to be responsible for tumor initiation and regeneration after chemotherapy. Previously, we showed that chemotherapy of non-small cell lung cancer (NSCLC) lines can select outgrowth highly tumorigenic metastatic CSCs. The high malignancy CSCs was associated with an efficient cytokine network. In this study, provide evidence blocking factor (SCF)-c-kit signaling is sufficient inhibit CSC proliferation survival promoted by were isolated from NSCLC as spheres...
Background It is unknown if there are cardiac abnormalities in persons who have recovered from coronavirus disease 2019 (COVID-19) without symptoms or those normal biomarkers and electrocardiograms. Purpose To evaluate involvement participants had COVID-19 clinical evidence of by using MRI. Materials Methods This prospective observational cohort study included 40 with moderate (n = 24) severe 16) pneumonia no cardiovascular medical history, were symptoms, electrocardiograms, serologic enzyme...
DNA-damaging treatments such as radiotherapy (RT) have become promising to improve the efficacy of immune checkpoint inhibitors by enhancing tumor immunogenicity. However, accompanying treatment-related detrimental events in normal tissues posed a major obstacle radioimmunotherapy and present new challenges dose delivery mode clinical RT. In study, ultrahigh rate FLASH X-ray irradiation was applied counteract intestinal toxicity radioimmunotherapy. context programmed cell death ligand-1...
Effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain growth, proliferation, and cytokine production. Epigenetic control genome also governs cell transcriptome lineage commitment maintenance. Cellular programs interact with epigenetic regulation by providing substrates for covalent modifications chromatin. By using complementary genetic, epigenetic, approaches, we revealed that tricarboxylic acid (TCA) cycle flux fueled biosynthetic...
Epithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, widespread distant metastasis at stages the typical biological behaviour small cell lung cancer (SCLC). Our previous reports showed that high expression of transcription factor E2F1 was involved SCLC, but role process EMT SCLC unknown. Immunohistochemistry performed to evaluate expressions related markers. Immunofluorescence used detect cytoskeletal proteins markers when silenced lines. Adenovirus...
Polyamine homeostasis determines T cell function.
Abstract Heightened aerobic glycolysis and glutaminolysis are characteristic metabolic phenotypes in cancer cells. Neuroblastoma (NBL), a devastating pediatric cancer, is featured by frequent genomic amplification of MYCN, member the Myc oncogene family that primarily expressed early stage embryonic development required for neural crest development. Here we report an enriched gene signature associated with MYCN children NBL. The partial knockdown suppresses NBL Conversely, forced...
Degradation of RBM39 by indisulam leads to exceptional response in high-risk neuroblastoma.
The fibroblast activation protein (FAP), overexpressed on cancer-associated fibroblasts (CAFs), has become a valuable target for tumor diagnosis and therapy. However, most FAP-based radioligands show insufficient uptake retention. In this study, three novel albumin-binding FAP ligands (denoted as FSDD0I, FSDD1I, FSDD3I) were labeled with 68Ga 177Lu to overcome these limitations. Cell-based studies molecular docking assays performed identify the specificity protein-binding properties FAP....
Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue sarcoma transformed by the pathognomonic Paired Box 3–Forkhead O1 (PAX3-FOXO1) fusion protein, which governs a core regulatory circuitry factor network. Here, we show that histone lysine demethylase 4B (KDM4B) therapeutic vulnerability for PAX3-FOXO1 + RMS. Genetic and pharmacologic inhibition of KDM4B substantially...
γ-Aminobutyrate (GAB), the biochemical form of (GABA) γ-aminobutyric acid, participates in shaping physiological processes, including immune response. How GAB metabolism is controlled to mediate such functions remains elusive. Here we show that one most abundant metabolites CD4
Objective To develop and validate a predictive model for hyperlipidemia risk among middle-aged older adult individuals in China, this study aims to offer an effective screening tool identifying those at risk. Methods In study, we included 6,629 individuals, aged 45 above, who met the inclusion criteria from 2015 China Health Retirement Longitudinal Study (CHARLS) as our research subjects. Utilizing LASSO regression multivariate Logistic method, analyzed independent factors associated with...
Background Nonalcoholic fatty liver disease (NAFLD) has emerged as a significant global health concern, with advanced fibrosis increasing mortality risks. Despite the abundance of dietary guidelines for managing NAFLD, precise impact diet quality on among individuals remains elusive. This study aims to explore influence five indexes NAFLD patients and patients. Methods utilized data from National Health Nutrition Examination Survey (NHANES) spanning 2005 2018 assess based Alternate...
<div>Abstract<p>c-MYC is an important driver of high-risk neuroblastoma. A lack c-MYC–driven genetically engineered mouse models (GEMM) has hampered the ability to better understand mechanisms neuroblastoma oncogenesis and develop effective therapies. In this study, we showed that conditional c-MYC induction via Cre recombinase driven by a tyrosine hydroxylase promoter led preponderance <i>PDX1</i><sup>+</sup> somatostatinoma, type pancreatic...
<p>Supplementary Data including 12 figures and table S1</p>