A5060102282- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Microtubule and mitosis dynamics
- Liver physiology and pathology
- 14-3-3 protein interactions
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- interferon and immune responses
- Extracellular vesicles in disease
- Distributed Control Multi-Agent Systems
- Advanced biosensing and bioanalysis techniques
- Distributed Sensor Networks and Detection Algorithms
- Hormonal Regulation and Hypertension
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Advanced Fiber Optic Sensors
- Apelin-related biomedical research
- Tryptophan and brain disorders
- Blood groups and transfusion
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Anhui Medical University
2024-2025
Zhongda Hospital Southeast University
2021-2024
Southeast University
2013-2024
Tongji University
2024
Taizhou Second People's Hospital
2019-2024
Xiamen University
2020-2024
Xiamen Maternal and Child Health Hospital
2024
Carnegie Mellon University
2024
Upon antigen stimulation, T lymphocytes undergo dramatic changes in metabolism to fulfill the bioenergetic, biosynthetic and redox demands of proliferation differentiation. Glutathione (GSH) plays an essential role controlling balance cell fate. While GSH can be recycled from disulfide (GSSG), inhibition this recycling pathway does not impact content murine By contrast, de novo synthesis GSH, by deleting either catalytic (Gclc) or modifier (Gclm) subunit glutamate-cysteine ligase (Gcl),...
Developing antibody agonists targeting the human apelin receptor (APJ) is a promising therapeutic approach for treatment of chronic heart failure. Here, we report structure-guided discovery single-domain (sdAb) agonist JN241-9, based on cocrystal structure APJ with an sdAb antagonist JN241, first class A G protein-coupled (GPCR) functional antibody. As revealed by structure, JN241 binds to extracellular side APJ, makes critical contacts second loop, and inserts CDR3 into ligand-binding...
The distributed filtering problem is studied for a multi-rate uniform sampling linear discrete system over sensor networks, where packet losses may occur during data exchange between nodes. transformed into single-rate by using virtual measurement method. At each node, the estimates received from neighbour nodes are fused matrix or scalar weighting according to their different estimation accuracy. A recursive filter with Kalman consensus structure devised based on estimate, gain and solved...
Previous studies have indicated that miR-146a-5p acts as an oncogene in several types of cancer, yet a tumor suppressor gene others. In non-small cell lung cancer (NSCLC), one report showed it was downregulated and played the role suppressor. However, another study overexpressed serum NSCLC patients compared to healthy controls. Therefore, is obvious further function necessary fully understand its importance. Herein, we verified miR- 146a- 5p NSCLC. Our data revealed expression level...
MicroRNAs are a class of non-coding single-stranded RNA, 20-23 nucleotide in length, which can be involved the regulation gene expression. Through binding with 3'-untranslated regions (3'-UTR), microRNAs cause degradation target mRNAs or inhibition translation, and thus regulating expression genes at post-transcriptional level. In this study, we found that miR-486-5p was significantly downregulated non-small cell lung cancer (NSCLC) tissues lines, suggesting might function as tumor...
Abstract Heightened aerobic glycolysis and glutaminolysis are characteristic metabolic phenotypes in cancer cells. Neuroblastoma (NBL), a devastating pediatric cancer, is featured by frequent genomic amplification of MYCN, member the Myc oncogene family that primarily expressed early stage embryonic development required for neural crest development. Here we report an enriched gene signature associated with MYCN children NBL. The partial knockdown suppresses NBL Conversely, forced...
This study aimed to quantitatively evaluate the therapeutic effect of decompression on mandibular cystic lesions using three-dimensional volumetric analysis and investigate factors influencing volume reduction patterns. A retrospective cohort 44 patients with lesions, including 12 unicystic ameloblastomas (UAB), odontogenic keratocysts (OKC), 20 nonkeratinizing cysts (NKC), was analyzed. Volumetric measurements before after were obtained Three- dimensional (3D) Slicer software CBCT data....
Novel molecularly targeted agents that block the development and metastasis of human brain metastatic breast cancer hold great promise for their translational value. In this study, we constructed a novel targeting composite peptide BRBP1-TAT-KLA comprising three elements: carcinoma cell (231-BR)-binding BRBP1, penetrating TAT proapoptotic KLA. This efficiently internalized in 231-BR cells consequently induced mitochondrial damage cellular apoptosis. Exposure to significantly decreased...
Paclitaxel (PTX) is a first-line chemotherapeutic drug for breast cancer, but PTX resistance often occurs in metastatic cancer. In addition, due to the poor targeting of drugs and presence blood–brain barrier (BBB), it hard effectively treat brain cancer using paclitaxel. Thus, urgent develop an effective delivery system treatment The current study found that TWF1 gene, epithelial–mesenchymal transition-associated was overexpressed (231-BR) cells associated with 231-BR cells. Knockdown by...
<title>Abstract</title> Hypopharyngeal squamous cell carcinoma (HPSCC), one of the most aggressive malignancies in upper aerodigestive tract, is characterized by poor prognosis and low overall survival rates. While alcohol consumption constitutes a key risk factor driving its progression, molecular mechanisms underlying HPSCC adaptation to alcohol-induced oxidative stress remain unclear. This study elucidates role CHCHD2 mediating alcohol-driven epithelial-mesenchymal transition (EMT)...
The flow cytometric quantitation of DNA content by DNA-binding fluorochrome, propidium iodide (PI) is the most widely used method for cell cycle analysis. However, commonly methods are time-consuming and labor-intensive incompatible with staining mitotic markers fluorescent-labeled antibodies. Here, we report an optimized simple protocol rapid simultaneous analysis characteristic phosphorylated proteins content, permitting quantification cells in mitosis, G1, S G2 stage a single assay....
Osteosarcoma (OS) is the most frequent primary malignant bone tumor. Ferroptosis, a form of regulated cell death, key tumor suppression mechanism. Although methionine adenosyltransferase II alpha (MAT2A) has been reported to inhibit several cells, it unclear whether inhibition MAT2A in OS cells can reduce ferroptosis. CCK-8, flow cytometry, and Transwell assays were performed evaluate viability, apoptosis/cycle, migration, respectively. The levels ferrous iron glutathione (GSH) measured...
Microglia are believed to be the key immune effectors of central microenvironment, and their dysregulation is associated with neuroinflammation mood disorders. Nucleotide-binding oligomerization domain-like receptor family caspase recruitment domain-containing five (NLRC5) a new member Nod-like family. Recently, NLRC5 has been reported expressed by microglia. Nonetheless, exact roles in microglial activation its function depression have not investigated yet. Herein, we found that reducing...
Ischemic stroke is a complex disease with multiple etiologies and clinical manifestations. Paired immunoglobulin-like receptor B (PirB), which originally thought to function exclusively in the immune system, now also known be expressed by neurons. A growing number of studies indicate that PirB can inhibit neurite outgrowth restrict neuronal plasticity. The aim study investigate whether an attractive theranostic target for ischemic stroke.First, we investigated spatial-temporal expression...
From unicellular to multicellular organisms, cell-cycle progression is tightly coupled biosynthetic and bioenergetic demands. Accumulating evidence has demonstrated the G1/S-phase transition as a key checkpoint where cells respond their metabolic status commit replicating genome. However, mechanism underlying coordination of metabolism G2/M-phase in mammalian remains unclear. Here, we show that activation AMP-activated protein kinase (AMPK), highly conserved cellular energy sensor,...
HLA-G and HLA-E are nonclassical human MHC class I molecules, which promote tolerance to NK cytotoxicity. MICA MICB known enhance the functions of T cells. However, expression these molecules has never been investigated in liver cancer. Using RT-PCR western blot, we aimed identify HLA-G, HLA-E, a panel 41 tissues dissecting from cancer patients China. mRNA was expressed 8 Human Hepatocellular Carcinoma (HCC) specimens 1 adjacent normal hepatocellular tissue. The protein found 7 mRNA-positive...
MHC class I (MHC-I) molecules are important components of the immune system. Recently MHC-I have been reported to also play roles in brain development and synaptic plasticity. In this study, we examine molecular mechanism(s) underlying activity-dependent expression using hippocampal neurons. Here report that neuronal level is dynamically regulated during after birth vivo. Kainic acid (KA) treatment significantly increases cultured neurons vitro, suggesting by activity. addition, KA...