A5083437982- Plant-Microbe Interactions and Immunity
- MicroRNA in disease regulation
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- Plant Molecular Biology Research
- Plant Disease Resistance and Genetics
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Plant tissue culture and regeneration
- Bacterial Infections and Vaccines
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Anaerobic Digestion and Biogas Production
- Cancer Cells and Metastasis
- Mitochondrial Function and Pathology
- Plant Pathogens and Fungal Diseases
- Chemokine receptors and signaling
- Cardiac tumors and thrombi
- Pneumonia and Respiratory Infections
- Photosynthetic Processes and Mechanisms
- Lung Cancer Treatments and Mutations
- Vanadium and Halogenation Chemistry
- Bone Metabolism and Diseases
- Circular RNAs in diseases
Chinese Academy of Sciences
2014-2025
State Key Laboratory of Plant Genomics
2014-2025
Northwest A&F University
2021-2025
University of South China
2025
Southern University of Science and Technology
2022-2025
Northwestern Polytechnical University
2022-2024
Shandong University of Traditional Chinese Medicine
2024
Chengdu University of Traditional Chinese Medicine
2024
University of Science and Technology Beijing
2021-2024
Beijing Forestry University
2020-2024
Summary Cutaneous wounds are among the most common soft tissue injuries and particularly hard to heal in aging. Caloric restriction ( CR ) is well documented extend longevity; pharmacologically, profound rejuvenative effects of mimetics have been uncovered, especially metformin MET ), resveratrol RSV rapamycin RAPA ). However, locally applied impacts functional differences these agents on wound healing remain be established. Here, we discovered that chronic topical administration , but not...
Abstract Background RNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted N7-methylguanosine (m 7 G) modification and its modifiers METTL1/WDR4 confirmed an oncogene role multiple cancers. However, the functions molecular mechanisms of acute myeloid leukemia (AML) remain be determined. Methods expression levels were quantified using qRT-PCR, western blot analysis on AML clinical samples, bioinformatics publicly available...
Background. There is major need for a more sensitive assay the diagnosis of pneumococcal community-acquired pneumonia (CAP). We hypothesized that nasopharyngeal (NP) proliferation may lead to microaspiration followed by pneumonia. therefore tested quantitative lytA real-time polymerase chain reaction (rtPCR) on NP swab samples from patients with and controls. Methods. In absence reference standard, composite diagnostic standard was considered positive in South African human immunodeficiency...
MicroRNAs emerge as critical post-transcriptional regulators in bone metabolism. We have previously reported vitro that miR-21 promotes osteogenesis, while studies also revealed a regulator of osteoclastogenesis and promoter osteoclast differentiation vitro. However, vivo data are still lacking identifying skeletal function miR-21, particularly its effects on osteoporosis. Here, using knockout (miR-21-/-) mice, we investigated development, remodeling loss. Unexpectedly, miR-21-/- mice...
Rational: Senescence of mesenchymal stem cells (MSCs) and the related functional decline osteogenesis have emerged as critical pathogenesis osteoporosis in aging.Resveratrol (RESV), a small molecular compound that safely mimics effects dietary restriction, has been well documented to extend lifespan lower organisms improve health aging rodents.However, whether RESV promotes function senescent alleviating age-related phenotypes remains largely unknown.Here, we intend investigate counteracts...
microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), application of mechanical force induces alveolar bone remodeling, but whether respond to contribute OTM is unknown. microRNA-21 (miR-21) has been previously reported vitro mediate stretch-induced osteogenic differentiation periodontal ligament stem cells support osteoclast differentiation. In this study, authors show that miR-21...
Abstract Tomato spotted wilt virus (TSWV) poses a significant threat as devastating pathogen to the global production and quality of tomato (Solanum lycopersicum). Mining novel resistance genes within germplasm is an effective environmentally friendly approach combat TSWV. In this study, we investigated mechanisms underlying high TSWV in specific line after experimental inoculation, despite not possessing any known genes. The candidate causal disease traits were finely mapped by constructing...
Verticillium dahliae Kleb. is a phytopathogenic fungus that causes wilt disease in wide range of crops, including cotton. The life cycle V. includes three vegetative phases: parasitic, saprophytic and dormant. dormant microsclerotia are the primary infectious propagules, which germinate when they stimulated by root exudates. In this study, we report first application Agrobacterium tumefaciens-mediated transformation (ATMT) for construction insertional mutants from virulent defoliating...
We prospectively examined the relation between pretrial serum vitamin D status and risk of oesophageal gastric cancers among subjects who developed cancer over 5.25 years follow-up, including 545 squamous cell carcinomas (ESCC), 353 cardia adenocarcinomas, 81 noncardia an age- sex-stratified random sample 1105 subjects. The distribution 25(OH)D was calculated using known sampling weights. For cohort as a whole, 25th, 50th, 75th percentile concentrations 25(OH)-vitamin were 19.6, 31.9, 48.7...
Abstract Gene-modified mesenchymal stem cell (MSC)-like cells with enhanced bone marrow homing and osteogenesis have been used in treating glucocorticoid-induced murine osteoporosis (GIOP). Recent preclinical studies further demonstrated the immunomodulatory anticatabolic potential of allogeneic MSCs under inflammatory autoimmune conditions. In this study, we investigated whether systemic infusion without genetic manipulation could prevent GIOP, anabolic effects existed, or immunomodulation...
MiRNAs in animals and plants play crucial roles diverse developmental processes under both normal stress conditions. miRNA-like small RNAs (milRNAs) identified some fungi remain functionally uncharacterized. Here, we a number of milRNAs Verticillium dahliae , soil-borne fungal pathogen responsible for devastating wilt diseases many crops. Accumulation V. milRNA1, named VdmilR1, was detected by RNA gel blotting. We show that the precursor gene VdMILR1 is transcribed polymerase II able to...
Immunotherapy is restricted by a complex tumor immunosuppressive microenvironment (TIM) and low drug delivery efficiency. Herein, multifunctional adjuvant micelle nanosystem (PPD/MPC) integrated with broken barriers re-education of three classes immune-tolerant cells constructed for cancer immunotherapy. The significantly conquers the penetration barrier via weakly acidic microenvironment-responsive size reduction charge reversal strategy. detached core MPC could effectively be internalized...
Auxin response factors (ARFs) play central roles in conferring auxin-mediated responses through selection of target genes plants. Despite their physiological importance, systematic analysis ARF potato have not been investigated yet. Our genome-wide identified 20 StARF (Solanum tuberosum ARF) from and found that they are unevenly distributed all the chromosomes except chromosome X. Sequence alignment conserved motif suggested presence typical domains but StARF18c lacks B3 DNA-binding domain....
Therapeutic effects of mesenchymal stem cell (MSC) infusion have been revealed in various human disorders, but impacts diseased micro-environments are only beginning to be noticed. Donor diabetic hyperglycemia is reported impair therapeutic efficacy cells. However, whether recipient condition also affects MSC-mediated therapy unknown. We and others previously shown that MSC could cure osteopenia, particularly ovariectomized (OVX) mice. Here, we discovered impaired on osteopenia type 1...
MicroRNAs (miRNAs) are involved in human cancers including myeloma. MiR-19a is one of the oncogenic miR-17-92 clusters, which identified as a key component many cancers. Nevertheless, function miR-19a myeloma has not been totally elucidated. The purpose this study to investigate biological functions MM. In vitro, we detected that miR-19a-3p overexpressed cells. proliferation and invision cells analyzed by MTT BD matrigel assays, respectively. Western blot was performed evaluate expression...