A5102271240- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Neurobiology and Insect Physiology Research
- Mitochondrial Function and Pathology
- Cardiac tumors and thrombi
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Silk-based biomaterials and applications
- RNA Research and Splicing
- Invertebrate Immune Response Mechanisms
- MicroRNA in disease regulation
- Insect Utilization and Effects
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Advanced MRI Techniques and Applications
- Circular RNAs in diseases
- Probiotics and Fermented Foods
- Innovative Teaching and Learning Methods
- Advanced Glycation End Products research
- Plant Gene Expression Analysis
- Bee Products Chemical Analysis
- Cancer-related gene regulation
- Motivation and Self-Concept in Sports
- Viral Infectious Diseases and Gene Expression in Insects
- Effects of Environmental Stressors on Livestock
Xinqiao Hospital
2021-2024
Fujian Agriculture and Forestry University
2023-2024
Nanjing Agricultural University
2024
Army Medical University
2021-2024
State Key Laboratory of Silkworm Genomic Biology
2017-2023
Southwest University
2017-2023
Army Medical College
2023
Nanjing Traditional Chinese Medicine Hospital
2022
Anhui Agricultural University
2022
Kyungnam University
2020
Abstract Background RNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted N7-methylguanosine (m 7 G) modification and its modifiers METTL1/WDR4 confirmed an oncogene role multiple cancers. However, the functions molecular mechanisms of acute myeloid leukemia (AML) remain be determined. Methods expression levels were quantified using qRT-PCR, western blot analysis on AML clinical samples, bioinformatics publicly available...
Background: Acute myeloid leukaemia (AML) is the most common acute in adults; AML highly heterogeneous and involves abnormalities at multiple omics levels.Small non-coding RNAs (sncRNAs) present body fluids are important regulatory molecules considered promising non-invasive clinical diagnostic biomarkers for disease.However, signature of sncRNA profile alteration patient serum bone marrow supernatant still under exploration.Methods: We examined data blood samples from 80 consecutive,...
Abstract Background Adaptation to high-altitude hypobaric hypoxia has been shown require a set of physiological traits enabled by an associated genetic modifications, as well transcriptome regulation. These lead both lifetime adaptation individuals at high altitudes and generational evolution populations seen for instance in those Tibet. Additionally, RNA which are sensitive environmental exposure, have play pivotal biological roles maintaining the functions organs. However, dynamic...
Transcription factors (TFs) play critical roles in mediating the plant response to various abiotic stresses, particularly heat stress. Plants respond elevated temperatures by modulating expression of genes involved diverse metabolic pathways, a regulatory process primarily governed multiple TFs networked configuration. Many TFs, such as WRKY, MYB, NAC, bZIP, zinc finger protein, AP2/ERF, DREB, ERF, bHLH, and brassinosteroids, are associated with shock factor (Hsf) families, stress tolerance....
Endometrial cancer (EC) is one of the most frequent malignancies occurring in female genital system. miR-205-5p has been reported to involve progression multiple malignancies, including EC. However, detail function and mechanism chemoresistance EC have not defined. qRT-PCR assay was performed detect abundance tissues cell lines. The sensitivity HEC-1-A RL95-2 cells PTX assessed based on results IC50. MTT flow cytometry (FCM) analyses were carried out determine proliferation apoptosis....
Due to domestication, the genetic diversity in cultivated rice is lower than that of wild species. Recent progress sequencing genomes and genus an important step identifying their differences associated with abiotic biotic stresses-resistant ability. Thus, this study, heat shock transcription factor (Hsf) genes 6 accessions, including Oryza barthii, glumaepatula, meridionalis, nivara, punctate rufipogon, 1 variety Nipponbare were firstly identified, evolution Hsf analyzed. Totally, 22, 23,...
Abstract Hypobaric hypoxia as an extreme environment in a plateau may have deleterious effects on human health. Studies indicated that rush entry into reduce male fertility and manifest decreased sperm counts weakened motility. RNA modifications are sensitive to environmental changes recently emerged novel post-transcriptional regulators spermatogenesis intergenerational epigenetic inheritance. In the present study, we generated mouse model simulating of 5500 m altitude for 35 days, which...
VgR, a member of the LDLR family, functions to transport vitellogenin into ovaries protome ovarian growth and embryonic development. In insects, only widely accepted ligand VgR is Vg. Recently, BmVgR has been shown interact with BmSP1 in vitro. Therefore, this study, we evaluated whether could certain cells. Although combine BmVg BmSP1, did not affect amount taken up by Sf9 Parallel immunofluorescence showed that most were localized inner oocyte membrane, showing tissue localization similar...
Tea residue, as a byproduct in tea processing, is highly nutritious and can be used good raw material for ruminant feed. This study aimed to investigate the effects of Lactiplantibacillus plantarum (L. plantarum) Bacillus licheniformis (B. licheniformis) mixed fermentation residue mixture (tea residue:wheat bran, 7:3) on chemical composition, bacterial community, rumen degradation rate. Changes composition community were evaluated after 0 (F0), 1 (F1), 3 (F3), 5 (F5) days fermentation. The...
Five Lycopodium alkaloids featuring novel C17N2 (1 and 2), C29N3 (3 4), C15N2 (5) skeletons were isolated from japonicum. Compound 1 is the first natural product containing a 3-aza[3.3.3]propellane motif. The structures of these compounds elucidated by spectroscopic analysis, X-ray crystallography, computational methods. Compounds 3-5 significantly inhibited TGF-β1-induced fibronectin deposition in HK-2 cells at nontoxic concentration 20 μM.
Hypoxia is a known stress factor in mammals and has been shown to potentially impair male fertility, which manifests as spermatogenic dysfunction decreased semen quality. Studies have that RNA modifications, the novel post-transcriptional regulators, are involved spermatogenesis, hypoxia-induced alterations modification testes sperm cells may be associated with impaired spermatogenesis mice. However, molecular mechanisms via modifications influence under hypoxic conditions unclear. In this...
Vitellogenin receptors (VgRs) transport vitellogenin (Vg) into oocytes, thereby promoting egg growth and embryonic development. VgRs recognize multiple ligands in oviparous animals, but their role insects is rarely reported. In this study, we investigated whether Bombyx mori VgR (BmVgR) binds transports lipoprotein-1 (BmLP1) lipoprotein-7 (BmLP7) of the 30 kDa lipoproteins (30 K proteins), which are essential for formation development B. . Protein sequence analysis showed BmLP7, similar to...
The dual luciferase reporter gene system provides sensitive readout, while it relies on a constitutively-expressed control for readout normalization. However, most standard genes are not constitutively expressed under all conditions. Here, we report an effective method to construct plasmid the that would be suitable hormone research in silkworm cell lines. First, modified BmVgP78M, stably-expressed constitutive promoter cells by mutating its hormone-related element. Then, constructed...
Testosterone derived from testicular Leydig cells (LCs) is important for male sheep, and the testis susceptible to external temperature. The present study aimed explore alleviating effect of selenomethionine (Se-Met) on heat-induced injury in Hu sheep LCs. Isolated LCs were exposed heat (41.5°C, exposure, HE) or not (37°C, nonheat NE), NE HE treated with 0 (C) 8 μmol/L (S) Se-Met 6 h. Cell viability, testosterone level, expression GPX1, HSD3B, apoptosis-related genes p38 mitogen-activated...
<b><i>Objectives:</i></b> Gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging is useful in assessing left ventricular (LV) and function. This study evaluated the LV functional changes after adenosine vasodilator stress, using gated SPECT. <b><i>Methods:</i></b> The population consisted of 70 patients who underwent adenosine-mediated stress rest All coronary angiography. Semi-quantitative assessment was analyzed...
This paper investigates the implementation of multi-rate low-density parity-check (QC-LDPC) codes. We propose a novel scheme to construct QC-LDPC codes from regular mother These can share single particular decoder which is designed for code previously in spite either irregularity or regularity. Based on this construction, encoding also be implemented by encoder with simple shift registers at speeds linearly proportional number bits parallel and length information sequence serial encoding....
This study investigates the positive and negative effects of online teaching on EFL students’ learning motivation. There are 26 English majors in a Chinese university participant this study. Data were collected from multiple sources: semi-structured interview direct observation. The result shows that course aspect, it has effect. In teacher both effects. But group effect, because losing interaction.