A5100736195- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cocoa and Sweet Potato Agronomy
- Plant Molecular Biology Research
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer-related gene regulation
- Plant Gene Expression Analysis
- Cardiac Fibrosis and Remodeling
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Photosynthetic Processes and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Plant Stress Responses and Tolerance
- Plant biochemistry and biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Plant Reproductive Biology
- Viral gastroenteritis research and epidemiology
- Pharmacological Effects of Medicinal Plants
- Fern and Epiphyte Biology
- Pharmacological Effects of Natural Compounds
- Ginger and Zingiberaceae research
Jiangsu Normal University
2019-2025
Louisiana State University
2021-2024
Shenyang Pharmaceutical University
2022-2024
Army Medical University
2023-2024
Xinxiang Medical University
2024
First Affiliated Hospital of Xinxiang Medical University
2024
Xinqiao Hospital
2023-2024
Louisiana State University Agricultural Center
2023-2024
Huazhong Agricultural University
2024
Shihezi University
2004-2022
As the most abundant internal modification of mRNA, N6 -methyladenosine (m6 A) methylation RNA is emerging as a new layer epitranscriptomic gene regulation in cellular processes, including embryo development, flowering-time control, microspore generation and fruit ripening, plants. However, role m6 A plant responses to environmental stimuli remains largely unexplored. In this study, we show that plays an important salt stress tolerance Arabidopsis. All mutants writer components, MTA, MTB,...
Abstract Background RNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted N7-methylguanosine (m 7 G) modification and its modifiers METTL1/WDR4 confirmed an oncogene role multiple cancers. However, the functions molecular mechanisms of acute myeloid leukemia (AML) remain be determined. Methods expression levels were quantified using qRT-PCR, western blot analysis on AML clinical samples, bioinformatics publicly available...
Leaf color is one of the well-sought traits in breeding program for Anthurium andraeanum Lind. Knowledge mechanisms anthuriums to produce leaves with different shades green would help effectively select desirable traits. In this study, micro- and ultra-structural physiological features on wild type leaf mutants (dark green, rubescent, etiolated, albino) A. 'Sonate' were analyzed. Results show that chloroplasts exhibited abnormal morphology distribution. Using next generation sequencing...
Abstract Background Intramuscular fat (IMF) and intramuscular connective tissue (IMC) are often seen in human myopathies central to beef quality. The mechanisms regulating their accumulation remain poorly understood. Here, we explored the possibility of using cattle as a novel model for mechanistic studies adipogenesis fibrogenesis. Methods Skeletal muscle single‐cell RNAseq was performed on three breeds, including Wagyu (high IMF), Brahman (abundant IMC but scarce Wagyu/Brahman cross....
We previously described several abnormally expressed long non-coding RNA (lncRNA) in tong squamous cell carcinomas (TSCCs) that might be associated with tumor progression. In the present study, we aimed to investigate role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) lncRNA metastatic potential TSCC cells and its molecular mechanisms.Expression levels MALAT-1 were examined via quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) 127 samples as well...
Abstract N 6-methyladenosine (m6A) RNA methylation has been shown to play a crucial role in plant development and floral transition. Two recent studies have identified FIONA1 as an m6A methyltransferase that regulates the transition Arabidopsis through influencing stability of CONSTANS (CO), SUPPRESSOR OF OVEREXPRESSION 1 (SOC1), FLOWERING LOCUS C (FLC). In this study, we confirmed is installs marks small group mRNAs. Furthermore, show that, addition its CO, SOC1, FLC, FIONA1-mediated...
// Ran Cheng 1, * , Ya-Jing Liu 2, Jun-Wei Cui 1 Man Yang Xiao-Ling Peng Li Zhan Wang Li-Zhang Zhu Si-Yi Lu Zou Xiao-Qin Wu Yu-Xia 2 You Zhou Zheng-Yu Fang Wei Department of Breast Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, China Institute Biomedical Research, PKU-HKUST Medical Center, First authors Correspondence to: Wei, email: rxwei1123@163.com Fang, fangzy796@163.com Keywords: aspirin, ER-positive breast cancer, c-myc, cyclinD1, tamoxifen resistance Received:...
Soil salinization is a major environmental stressor that reduces the growth and yield of crops. Maintaining balance ions under salinity vital for plant salt tolerance; however, little known about correlation between tolerance crops ion contents their roots shoots. Here, we investigated poorly understood salt-tolerance mechanisms, particularly regarding (particularly Na+), in Brassica napus subsp. L., an agriculturally important species. Twenty B. inbred lines were randomly chosen from five...
The role of serum albumin in the risk diabetic peripheral neuropathy (DPN) remains unclear. This study aimed to explore relationship between level and DPN, examine any possible effect modifiers among patients with type 2 diabetes mellitus.This cross-sectional was conducted Jiangxi, China, from May 2012 December 2014. Serum levels were determined 523 subjects, association DPN evaluated using linear regression models (odds ratio [OR] corresponding 95% confidence interval [CI]).There a...
Transforming growth factor β (TGFβ) has been shown to be a multifunctional cytokine required for embryonic development and regulation of trophoblast cell behaviors. In the present study, non-transformed cell-line representative normal human (NPC) was used examine effect TGFβ1 on adhesion invasion. vitro assay showed that could significantly promote intercellular adhesion, while inhibiting invasion across collagen I-coated filter. Reverse transcription (RT)-PCR gelatin zymography demonstrated...
Transcriptional networks orchestrate complex developmental processes, and such are commonly instigated by master regulators for development. By now, considerable progress has been made in elucidating GATA factor-dependent genetic that control red blood cell Here we reported GATA-1 GATA-2 co-regulated the expression of two microRNA genes, microRNA-27a microRNA-24, with critical roles regulating erythroid differentiation. In general, occupied miR-27a∼24 promoter repressed their transcription...
WRKY DNA-binding protein (WRKY) is a large gene family involved in plant responses and adaptation to salt, drought, cold heat stresses. Sweet potato from the genus Ipomoea staple food crop, but genes species remain unknown date. Hence, we carried out genome-wide analysis of WRKYs trifida (H.B.K.) G. Don., wild ancestor sweet potato.A total 83 encoding 96 proteins were identified I. trifida, their distribution, duplication, structure, phylogeny expression patterns studied. ItfWRKYs...
Sweetpotato is the seventh largest crop worldwide, and soil salinization a major environmental stress limiting its yield. Recent studies have shown that noncoding RNAs (ncRNAs) play important regulatory roles in plant responses to abiotic stress. However, ncRNAs sweetpotato remain largely unexplored. This study analyzed characteristics of salt-responsive adventitious roots under salt via whole-transcriptome RNA sequencing. The results revealed 3175 messenger (mRNAs), 458 microRNAs (miRNAs),...
Abstract Background To explore the efficacy of a prediction model based on diffusion‐weighted imaging (DWI) features extracted from deep learning (DL) and radiomics combined with clinical parameters apparent diffusion coefficient (ADC) values to identify microsatellite instability (MSI) in endometrial cancer (EC). Methods This study included cohort 116 patients EC, who were subsequently divided into training ( n = 81) test 35) sets. From DWI, conventional convolutional neural network‐based...
Our recent studies show that the reduced activity of epithelial sodium channels (ENaC) in endothelial cells accounts for adaptation vasculature to salt Sprague-Dawley rats. The present study examines a hypothesis enhanced ENaC mediates loss vasorelaxation Dahl salt-sensitive (SS) rats.We used cell-attached patch-clamp technique record split-open mesenteric arteries. Western blot and immunofluorescence staining were evaluate levels aldosterone, ENaC, eNOS NO. Blood pressure was measured with...
Limonium bicolor is a dicotyledonous recretohalophyte with several multicellular salt glands on the leaves. The plant can directly secrete excess onto leaf surface through to maintain ion homeostasis under stress. Therefore, it of great significance study functions genes related gland development and tolerance. In this study, an R1-type MYB transcription factor gene was screened from L. bicolor, named LbMYB48, its expression strongly induced by Subcellular localization analysis showed that...
Human adenovirus (HAdV) is increasingly recognized as a major cause of human respiratory tract viral infections. Its outbreaks and epidemics in various populations resulted considerable morbidity mortality. Therefore, rapid specific assay for HAdV clinical samples crucial importance to diagnosing The present study aimed develop evaluate multiplex quantitative polymerase chain reaction (qPCR) the detection accurate quantification B, C E. lower limit this was two genomic copies per reaction,...