Liang Chen

ORCID: 0000-0002-8765-4570
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Research Areas
  • Composite Material Mechanics
  • Dendrimers and Hyperbranched Polymers
  • Numerical methods in engineering
  • Advanced Polymer Synthesis and Characterization
  • Polymer crystallization and properties
  • Mechanical Behavior of Composites
  • Electrospun Nanofibers in Biomedical Applications
  • Polymer Nanocomposites and Properties
  • Tissue Engineering and Regenerative Medicine
  • Sarcoma Diagnosis and Treatment
  • Distributed Control Multi-Agent Systems
  • Analytical Chemistry and Chromatography
  • Supramolecular Chemistry and Complexes
  • Synthesis and properties of polymers
  • Job Satisfaction and Organizational Behavior
  • Mesoporous Materials and Catalysis
  • Salivary Gland Tumors Diagnosis and Treatment
  • Polymer Surface Interaction Studies
  • Total Knee Arthroplasty Outcomes
  • Error Correcting Code Techniques
  • Silk-based biomaterials and applications
  • Composite Structure Analysis and Optimization
  • Supramolecular Self-Assembly in Materials
  • RNA Interference and Gene Delivery
  • Contact Mechanics and Variational Inequalities

Shanghai Jiao Tong University
2016-2025

Shanghai Ninth People's Hospital
2022-2025

Ruijin Hospital
2013-2024

University of Science and Technology of China
2014-2023

Tibet Autonomous Region People's Hospital
2023

XinHua Hospital
2017-2023

Nanjing Sport Institute
2022-2023

East China University of Science and Technology
2007-2022

Renji Hospital
2022

Shanghai Chest Hospital
2019-2021

Abstract The anther cuticle and microspore exine act as protective barriers for the male gametophyte pollen grain, but relatively little is known about mechanisms underlying biosynthesis of monomers which they are composed. We report here isolation characterization a rice (Oryza sativa) sterile mutant, cyp704B2, exhibits swollen sporophytic tapetal layer, aborted grains without detectable exine, undeveloped cuticle. In addition, chemical composition analysis indicated that cutin were hardly...

10.1105/tpc.109.070326 article EN cc-by The Plant Cell 2010-01-01

Abstract Background Most of the natural extracellular matrix (ECM) is a three-dimensional (3D) network structure micro/nanofibers for cell adhesion and growth 3D. Electrospun fibers distinctive mimicked 2D ECM, however, it impossible to simulate 3D ECM because longitudinal collapse continuous micro/nanofibers. Herein, electrospun micro/nano-fibrous sponge was fabricated via electrospinning, homogenization, shaping thermal crosslinking tissue regeneration cells vascular. Results Fibrous...

10.1186/s12951-021-00878-5 article EN cc-by Journal of Nanobiotechnology 2021-05-08

The localization and accumulation of drugs in the body determine their therapeutic effects; however, specific microstructure damaged tissues hinders drug delivery. Currently, there is a shortage effective carriers to breach these barriers achieve efficient tissue cellular delivery drugs. In this study, an injectable double positively charged functional hydrogel microsphere with "targeting cartilage extracellular matrix", "cartilage penetration", "cellular phagocytosis" designed for matching...

10.1002/smll.202202156 article EN Small 2022-09-03

Abstract The high density structure of cartilage matrix negative charge seriously hinders the penetration and enrichment drugs/genes into tissue. In this study, hexachlorocyclotriphosphonitrile is used as core to prepare self‐polymerized phosphorus dendrimers with inflammatory reaction through substitution condensation reaction. vector can achieve efficient damaged articular (slightly acidic condition) effective anchoring (normal physiological size effect under response. Meanwhile, a gene...

10.1002/adfm.202305635 article EN Advanced Functional Materials 2023-08-11

A tumor targeted and pH-responsive drug release system that is based on folic acid (FA) conjugated to poly(ethylene glycol) (PEG)-modified dendrimers (PAMAM) with doxorubicin (DOX) superparamagnetic iron oxide (Fe3O4) (FA-PEG-PAMAM-DOX@IONPs) has been constructed characterized. IONPs were stabilized by FA-PEG-G3.5 PAMAM dendrimers. The anticancer DOX was the dendrimer segments of amino-stabilized using hydrazine as linker via hydrazone bonds, which are cleavable can be used an ideal system....

10.1039/c2jm16792a article EN Journal of Materials Chemistry 2012-01-01

In contrast to an expected Ostwald-like ripening of amyloid assemblies, the nucleating core Dutch mutant Aβ peptide Alzheimer’s disease assembles through a series conformational transitions. Structural characterization intermediate assemblies by isotope-edited IR and solid-state NMR reveals unexpected strand orientation intermediates suggests new nucleation mechanisms in progressive assembly pathway.

10.1021/ja508621b article EN Journal of the American Chemical Society 2014-10-14

Abstract The prevalence of infertility caused by endometrial defects is steadily increasing, posing a significant challenge to women's reproductive health. In this study, injectable “homing‐like” bioactive decellularized extracellular matrix short‐fibers (DEFs) porcine skin origin are innovatively designed for and fertility restoration. DEFs can effectively bind cells through noncovalent dipole interactions release growth factors in situ. vitro, the attracted effect, enabling cell adhesion,...

10.1002/advs.202306507 article EN cc-by Advanced Science 2024-03-19

Background: The correlation between the Miniaci angle and presurgical hip-knee-ankle (HKA) angle, weightbearing line (WBL) percentage, changes in HKA (ΔHKA angle) WBL percentage (ΔWBL percentage) is significant opening-wedge high tibial osteotomy (OWHTO). conversion formulas that interrelate with pre-HKA (formula 1), pre-WBL 2), ΔHKA 3), ΔWBL 4) have been derived through linear regression analysis. However, accuracy of has not validated. Purpose: To validate precision targeting various...

10.1177/23259671241308916 article EN cc-by-nc-nd Orthopaedic Journal of Sports Medicine 2025-02-01

A new class of crystalline inclusion complexes a multiarm hyperbranched polyether combined with various cyclodextrins (CDs) was successfully prepared. Using self-condensing ring-opening polymerization, kind poly(3-ethyl-3-oxetanemethanol) core and multiple linear poly(ethylene glycol) (PEG) arms obtained. It has been found that this can be dissolved in water. Adding α-CDs to the solution, molecular recognition results formation based on noncovalent interactions between PEG particles α-CDs....

10.1021/la035740a article EN Langmuir 2003-12-10

Edge computing provides physical resources closer to end users, becoming a good complement cloud computing. With the rapid development of container technology and microservice architecture, orchestration has become hot issue. However, container-based scheduling problem in edge is still urgent be solved. In this paper, we first formulate as multi-objective optimization problem, aiming optimize network latency among microservices, reliability applications load balancing cluster. We further...

10.2298/csis200229041f article EN cc-by-nc-nd Computer Science and Information Systems 2020-11-24

Protein hydrogels are an important class of materials for applications in biotechnology and medicine. The fine-tuning their sequence, molecular weight, stereochemistry offers unique opportunities to engineer biofunctionality, biocompatibility, biodegradability into these materials. Here we report a new family redox-sensitive protein with controllable mechanical properties composed recombinant silk-elastin-like polymers (SELPs). SELPs were designed synthesized different ratios silk-to-elastin...

10.1021/acs.biomac.6b00973 article EN Biomacromolecules 2016-10-04

Abstract Bone infection is an inflammatory bone disease caused by infectious microorganisms, which can lead to progressive destruction and loss. It still urgent unmet clinical need develop a rapid effective sterilized method reduce infection. In this study, near‐infrared (NIR) light‐responsive polydopamine (PDA) adherent Copper nanoparticles (Cu‐NPs) are constructed using electrospun poly lactic acid (PLLA) fibers as substrate (PLLA@PDA/Cu). Dopamine (DA) self‐polymerized synthesize the PDA...

10.1002/admi.202300113 article EN cc-by Advanced Materials Interfaces 2023-08-03

A supramolecular method to control polymer architectures (see picture) is demonstrated with the synthesis of a series poly(sulfone–amine) samples various degrees branching merely by changing amount host (β-cyclodextrin) present. Further modification chains allows preparation condensation polymers peculiar topological structures, functionalities, and properties.

10.1002/anie.200502306 article EN Angewandte Chemie International Edition 2005-11-22

Drawing from the grounded theory of work engagement, this research aims to explore three essential yet previously unexamined pathways-work meaningfulness, emotion regulation, and job competence in simultaneously transmitting effects mindfulness training employee experience engagement. We employed a six-wave quasi-experimental design recruited 129 employees (77 experimental group 59 control group) participate quasi-experiment, tested our simultaneous mediating models using structural equation...

10.3389/fpsyg.2022.997638 article EN cc-by Frontiers in Psychology 2022-10-26

Novel nucleophilic ligands were synthesized from oleic acid conjugated with 2-mercaptoimidazole via a UV-initiated thiol−ene reaction, and by condensation of trans-9,10-epoxystearic 4(5)-imidazoledithiocarboxylic acid. Nanoparticles (NPs) 10−100 nm Ag(0) or Co(0) cores obtained reduction Ag+ Co2+ borohydride in N,N-dimethylformamide aqueous solutions respectively. The NPs capped 9,10-epoxystearic acids further covalently bound to functionalized imidazole moieties enabled facile hydrolysis...

10.1021/cm1018508 article EN Chemistry of Materials 2010-08-20

Abstract Magnesium alloy covered stents have rarely been used in the common carotid artery (CCA). We evaluated long-term efficacy of magnesium a lateral aneurysm model rabbit CCA. (group A, n = 7) or Willis B, 5) were inserted 12 New Zealand White rabbits and they followed up for months. The feasibility occlusion was studied through angiograms; changes vessel area lumen assessed with IVUS. Complete aneurysmal achieved all aneurysms. Angiography showed that diameter stented CCA group A at 6...

10.1038/srep37401 article EN cc-by Scientific Reports 2016-11-21
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