A5100677549- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Health and Contraception
- Ectopic Pregnancy Diagnosis and Management
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Land Use and Ecosystem Services
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Hormonal Regulation and Hypertension
- Ovarian cancer diagnosis and treatment
- Protein Structure and Dynamics
- Apelin-related biomedical research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Environmental Changes in China
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Inflammasome and immune disorders
Sun Yat-sen University
2025
Renji Hospital
2017-2024
Shanghai Jiao Tong University
2014-2024
Fujian Institute of Oceanography
2024
Ministry of Natural Resources
2024
Liaoning Normal University
2024
Zhujiang Hospital
2022-2023
Southern Medical University
2003-2023
XinHua Hospital
2020-2022
Shandong University
2022
Implantation failure remains a critical barrier to in vitro fertilization. Prednisone, as an immune-regulatory agent, is widely used improve the probability of implantation and pregnancy, although evidence for efficacy inadequate.To determine 10 mg prednisone compared with placebo on live birth among women recurrent failure.A double-blind, placebo-controlled, randomized clinical trial conducted at 8 fertility centers China. Eligible who had history 2 or more unsuccessful embryo transfer...
Abstract STUDY QUESTION Does ovarian ferroptosis play an active role in the development of polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Increased was present PCOS ovaries and inhibition with ferrostatin-1 (Fer-1) ameliorated morphology anovulation. WHAT IS KNOWN ALREADY Programmed cell death plays a fundamental follicle development. However, types mechanisms involved are yet to be elucidated. Ferroptosis is recently discovered iron-dependent programmed death. Impaired iron metabolism...
Hyperandrogenism is one of the most common causes for anovulation in women and increases risk metabolic disorder PCOS patients. Autophagy plays an important role dysfunction endocrine anovulation. However, relationship between hyperandrogenism autophagy human granulosa cells patients remains unclear. By collecting from non-PCOS patients, we found that abundance autophagy-related genes ATG5, ATG7, BECN1 mRNA ratio marker protein light chain 3B II/I (LC3 II/I) were significantly increased...
The soluble dietary fiber polydextrose (PDX) is a randomly linked glucose oligomer containing small amounts of sorbitol and citric acid widely used in the food industry. However, whether PDX can prevent treat obesity high-fat diet (HFD)-fed mice has not been directly investigated, further studies are needed to better understand complex interactions among PDX, adipose tissue inflammation gut microbiota. In present study, reduced body weight, fasting blood (FBG), accumulation, adipocyte...
Endometrial decidualization is a prerequisite for implantation, and impaired associated with recurrent implantation failure (RIF). Coding genes of the HOX family have been clarified as critical regulators in endometrial decidualization, but role long non-coding RNAs (lncRNAs) gene has yet to be determined. The aim this study was clarify possible roles lncRNAs decidualization. In study, we identified that HOXA11-AS most reduced lncRNA human endometrium during window it elevated RIF patients....
Abstract The prevalence of infertility caused by endometrial defects is steadily increasing, posing a significant challenge to women's reproductive health. In this study, injectable “homing‐like” bioactive decellularized extracellular matrix short‐fibers (DEFs) porcine skin origin are innovatively designed for and fertility restoration. DEFs can effectively bind cells through noncovalent dipole interactions release growth factors in situ. vitro, the attracted effect, enabling cell adhesion,...
Ambient air pollution has adverse effects on the reproductive system. However, inconsistent conclusions were reached from different studies with regard to pollutants and pregnancy outcomes, especially livebirth rate in assisted technology (ART) windows of exposure.
The acceleration of urbanization and development marine resources has led to the imbalance land structure, which threatens sustainable human living environment. Exploring spatial distribution patterns land-sea its spatio-temporal evolution characteristics is an important initiative resolve conflicts optimise structure use. Taking Liaoning Coastal Economic Belt as example, this paper constructs a system measure value Production-Living-Ecological Functions (PLEF) coastal zone realizes...
The neglect of occult lymph nodes metastasis (OLNM) is one the pivotal causes early non-small cell lung cancer (NSCLC) recurrence after local treatments such as stereotactic body radiotherapy (SBRT) or surgery. This study aimed to develop and validate a computed tomography (CT)-based radiomics deep learning (DL) fusion model for predicting non-invasive OLNM. Patients with radiologically node-negative adenocarcinoma from two centers were retrospectively analyzed. We developed clinical,...
The proinflammatory cytokine interleukin-1β (IL-1β) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis granulosa cells. However, the exact effect of IL-1β on progesterone synthesis cells underlying mechanism remain unclear. By using cultured granulosa-lutein collected from women undergoing vitro fertilization or intracytoplasmic sperm injection, we found that upregulated steroidogenic acute regulatory protein...
Embryo implantation rate remains an inefficient process in vitro fertilization and embryo transfer (IVF-ET) cycles. The role long noncoding RNA (lncRNA) plays unclear. We aimed to investigate the expression pattern of lncRNA TCL1 upstream neural differentiation-associated (TUNAR) human cyclic endometrium clarify TUNAR development endometrial receptivity. Endometrial biopsies were collected at late proliferative phase, luteinizing hormone (LH)+2 LH+7, from patients with or without recurrent...
Abstract Context Endometrial insulin resistance (IR) may account for the endometrial dysfunction in polycystic ovary syndrome (PCOS). The underlying mechanism remains to be elucidated. Objective To investigate whether abundance of 11β-hydroxysteroid dehydrogenases (11β-HSDs) 1 and 2 cortisol as well signaling pathway are altered PCOS endometrium clarify relationship between IR local cortisol. Design We measured cortisone concentrations, 11β-HSD1 11β-HSD2, core molecules biopsies collected...
Reliable preoperative diagnosis of malignant thyroid tumors remains challenging because the inconclusive cytological examination fine‐needle aspiration biopsies. Although numerous studies have successfully demonstrated use high‐throughput molecular diagnostics in cancer prediction, application microarrays routine clinical limited. Our aim was, therefore, to identify a small subset genes develop practical and inexpensive diagnostic tool for use. We developed two‐step feature selection method...
Abstract STUDY QUESTION Does severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the frozen–thawed embryo transfer (FET) cycle affect implantation and pregnancy rates? SUMMARY ANSWER There is no evidence that SARS-CoV-2 of women FET negatively affects rates. WHAT IS KNOWN ALREADY Coronavirus disease 2019 (COVID-19), as a multi-systemic disease, poses threat to reproductive health. However, effects on following fertility treatments, particularly FET, remain largely...
Coastal wetlands are important areas with valuable natural resources and diverse biodiversity. Due to the influence of both factors human activities, landscape coastal undergoes significant changes. It is crucial systematically monitor analyze dynamic changes in wetland cover over a long-term time series. In this paper, series remote sensing classification process was proposed, which integrated feature selection sample migration. Utilizing Google Earth Engine (GEE) Landsat TM/ETM/OLI image...
Abstract Background Recurrent implantation failure (RIF) brings great challenges to clinicians and causes deep frustration patients. Previous data has suggested that prednisone may play a promising role in the establishment of pregnancy help improve outcome women with RIF. But there is insufficient evidence from randomized clinical trials had adequate power determine if can enhance live births as primary outcome. Methods/design This trial prospective, multicenter, randomized, double-blind,...
Insulin resistance (IR) contributes to ovarian dysfunctions in polycystic syndrome (PCOS) patients. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver response inflammation. In addition its role inflammation, SAA1 may participate IR development peripheral tissues. Yet, expressional regulation of ovary and pathogenesis PCOS remain elusive.Follicular fluid, granulosa cells venous blood were collected from non-PCOS patients with without measure abundance for...
Essential genes often play key roles in biological processes and mutations these will have a great impact on an organism's survival reproduction. Studying lethal phenotypes provide important information about the function of gene product direct therapy. Traditionally, essential been identified through single-gene knockout experiments, transposon mutagenesis, or antisense RNA inhibitions. However, experimental methods are expensive, labor-intensive, time-consuming. In addition, such...
Genes with indispensable functions are identified as essential; however, the traditional gene-level studies of essentiality have several limitations. In this study, we characterized gene from a new perspective protein domains, independent structural or functional units polypeptide chain.To identify such essential developed an Expectation-Maximization (EM) algorithm-based Essential Domain Prediction (EDP) Model. With simulated datasets, model provided convergent results given different...