A5100672459- Hepatitis B Virus Studies
- Hepatitis C virus research
- Cardiac Ischemia and Reperfusion
- Monoclonal and Polyclonal Antibodies Research
- Diet and metabolism studies
- Nerve injury and regeneration
- Biochemical effects in animals
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Nosocomial Infections in ICU
- Traditional Chinese Medicine Studies
- Neurological Disease Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Pancreatic function and diabetes
- Diphtheria, Corynebacterium, and Tetanus
- IL-33, ST2, and ILC Pathways
- Traditional Chinese Medicine Analysis
- Circadian rhythm and melatonin
- Ophthalmology and Eye Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Organ Transplantation Techniques and Outcomes
- Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
Renji Hospital
2007-2024
Shanghai Jiao Tong University
2007-2024
Henan University of Traditional Chinese Medicine
2023
Shaanxi University of Chinese Medicine
2010-2023
Harbin Medical University
2019-2023
University of Hong Kong
2012-2023
Chinese Academy of Agricultural Sciences
2023
Institute of Animal Sciences
2023
Zhengzhou University
2023
Nantong University
2023
Trimethylamine-N-oxide (TMAO), a metabolite of gut microbiota, has been implicated in the pathogenesis Alzheimer's disease (AD). However, mechanisms by which TMAO influence cognitive and pathological processes AD have not investigated. In this study, we found that circulating levels displayed an age-related increase both WT APP/PS1 mice association with AD-like behavioral profile. Reduced 3,3-Dimethyl-1-butanol (DMB) treatment ameliorated deterioration long-term potentiation (LTP) mice....
Electroacupuncture (EA) is used clinically for the treatment of constipation. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in colonic motility; however it unknown whether alterations 5-HT are associated with EA. In this study, effect and mechanism EA at acupuncture points LI11 ST37 were examined using a cold saline-induced rat model constipation.A constipation was induced by saline gavage 24 Sprague-Dawley rats. A further six rats included as Control group. The constipated...
Abstract The prevalence of infertility caused by endometrial defects is steadily increasing, posing a significant challenge to women's reproductive health. In this study, injectable “homing‐like” bioactive decellularized extracellular matrix short‐fibers (DEFs) porcine skin origin are innovatively designed for and fertility restoration. DEFs can effectively bind cells through noncovalent dipole interactions release growth factors in situ. vitro, the attracted effect, enabling cell adhesion,...
The proinflammatory cytokine interleukin-1β (IL-1β) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis granulosa cells. However, the exact effect of IL-1β on progesterone synthesis cells underlying mechanism remain unclear. By using cultured granulosa-lutein collected from women undergoing vitro fertilization or intracytoplasmic sperm injection, we found that upregulated steroidogenic acute regulatory protein...
To investigate the effects of combined acupuncture and eugenol on learning-memory ability antioxidation system hippocampus in Alzheimer disease (AD) rats. Sixty Sprague Dawley rats, weighing (300±10) g, were randomly divided with 10 rats per group into a normal control group, AD model cut olfactory nerve Xiu three-needle group. The was established by injection amyloid β1-40 (Aβ 1-40). Morris maze tests conducted for evaluating ability. Content malondialdehyde (MDA) activities superoxide...
MK-801, also known as dizocilpine, is a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist that induces schizophrenia-like symptoms. Our previous study showed brain-derived neurotrophic factor (BDNF) signaling was upregulated in cultured hippocampal astrocytes response to MK-801. However, dysfunctional NMDA receptors are mainly expressed neurons. The effects of MK-801 on neuron-derived BDNF expression and risperidone MK-801-induced cognitive impairment changes unclear. To...
The development of diabetic macrovascular complications is a multifactorial process, and melatonin may possess cardiovascular protective properties. This study was designed to evaluate whether attenuates arteriosclerosis endothelial permeability by suppressing the myosin light-chain kinase (MLCK)/myosin phosphorylation (p-MLC) system via mitogen-activated protein (MAPK) signaling pathway or phosphatase-targeting subunit (p-MYPT)/p-MLC in diabetes mellitus (DM). Rats were randomly divided...
BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting joints. This research aimed to explore the effects of Xinfeng capsules (XFC) on cardiac injury in adjuvant (AA) model rats and assessed associated mechanism. MATERIAL AND METHODS:An rat was established by intracutaneously injection with Freund's complete (FCA). Model were divided into 4 groups: an AA group, astragalus polysaccharides (APS) methotrexate (MTX) XFC triptolide (TPT) group. Hematoxylin-eosin (HE)...
The dependence of plant health and crop quality on the epiphytic microbial community has been extensively addressed, but little is known about plant-associated communities under natural conditions. In this study, bacterial fungal grape leaves were analyzed by 16S rRNA gene internal transcribed spacer high-throughput sequencing, respectively. results showed differences in composition leaf samples nine wine varieties. most abundant genus was Pseudomonas, top three varieties with Pseudomonas...
The aim of the present study was to determine levels soluble fractalkine (sFKN) and expression CX3CR1 in neuropsychiatric systemic lupus erythematosus (NPSLE). Disease activity SLE assessed using Activity Index (SLEDAI). mRNA FKN were quantified reverse transcription-quantitative polymerase chain reaction. Levels sFKN serum cerebrospinal fluid (CSF) measured enzyme-linked immunosorbent assays. peripheral blood mononuclear cells from patients with NPSLE, non-NPSLE Behcet's disease...
The aim of the present study was to investigate role G‑protein‑coupled receptor 30 (GPR30) in long‑term 17β‑estradiol (E2) deprivation (LTED) a rat model with global cerebral ischemia (GCI), and its therapeutic target for ischemic stroke clinical setting. Following bilateral ovariectomy, GCI induced rats 1 or 10 weeks post‑surgery. To determine protein mRNA expression levels GPR30 hippocampal CA1 region LTED rats, short‑term E2 (STED) naturally aging western blot analysis reverse...
Background: To understand the prevalence of diabetic retinopathy (DR) in Shenzhen and to analyze risk factors for occurrence development DR. Based on comprehensive information system diabetes prevention control communities 2019, six community health service centers were used as research sites carry out multicenter, cross-sectional screening studies. Methods: Cluster random sampling was collect data from 904 patients with Shenzhen. The DR vision-threatening (VTDR) analyzed, multivariate...
The standard addition strategy allows accurate pharmacodynamic compounds screening and embodies the systematic nature of TCM.
The envelope glycoprotein E2 of hepatitis C virus (HCV) has been shown to bind human target cells. Anti‐E2 antibodies have associated with both recovery from natural infection in humans and protection challenge homologous HCV chimpanzees. Therefore become a major for the development anti‐HCV vaccines. Two fragments [amino acids (aa) 450–565 aa 385–565] derived subtype 1b genome were expressed as N‐terminally hexahistidine‐tagged proteins Escherichia coli purified over 85% purity. Both...
AIM: To establish a convenient immunoassay method based on recombinant antigen preS1(21-119aa) to detect anti-preS1 antibodies and evaluate the clinical significance of in hepatitis B. METHODS:The expression plasmid pET-28a-preS1 was constructed, large quantity fragment HBsAg protein obtained.The preS1 purified by Ni 2+ -IDA affinity chromatography used as coated indirect ELISA streptavidin-biotin system for detection sera from HBV-infected patients.For follow-up study, serial were collected...