A5100389601- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Immune Cell Function and Interaction
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Chromatography in Natural Products
- Phytochemistry and biological activity of medicinal plants
- Phytochemistry and Biological Activities
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Menstrual Health and Disorders
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Plant-derived Lignans Synthesis and Bioactivity
- Gout, Hyperuricemia, Uric Acid
- Drug-Induced Hepatotoxicity and Protection
- bioluminescence and chemiluminescence research
Tianjin University of Traditional Chinese Medicine
2016-2025
Chongqing Academy of Chinese Materia Medica
2025
Northeast Normal University
2023-2024
China Agricultural University
2021
In-Q-Tel
2019
Cancer Research UK
2014
Cockayne syndrome (CS) is a multisystem disorder with severe neurological symptoms. The majority of CS patients carry mutations in group B (CSB), best known for its role transcription-coupled nucleotide excision repair. Indeed, because various repair pathways are compromised patient cells, widely considered genome instability syndrome. Here, we investigate the connection between neuropathology and dysregulation gene expression. Transcriptome analysis human fibroblasts revealed that even...
Heart failure is a common systemic disease with high morbidity and mortality worldwide. Doxorubicin (DOX) commonly used anthracycline broad-spectrum antitumor antibiotic strong effect definite curative effect. However, cardiotoxicity the adverse reaction of drug dose cumulative toxicity, but mechanism still unclear. In this study, proteomics metabonomics techniques were to analyze tissue plasma DOX-induced heart (HF) in rats clarify molecular harmful effects DOX on cardiac metabolism...
Background: Chemotherapy-induced immunosuppression significantly impacts patient’s quality of life. Umbelliferone (UMB) is known for its anti-inflammatory, antioxidant, and anti-apoptotic properties, but effects on cyclophosphamide (CTX)-induced need further study. Methods: We established a CTX-induced immunosuppressed mouse model administered varying doses UMB. Immune function was assessed by evaluating white blood cells, lymphocytes, thymus spleen indices, CD4+/CD8+ T cell ratios. Serum...
Non-alcoholic steatohepatitis (NASH) poses a serious threat to human health. Alisol B 23-Acetate (AB23A) has shown beneficial effects on NASH, but its mechanism of action remains unclear. We conducted in vitro experiments by inducing L02 cell damage with free fatty acids (FFA) and administering various concentrations AB23A. found that AB23A intervention reduced triglyceride (TG) levels FFA-induced cells improved cellular steatosis. Transcriptomic analysis revealed significantly downregulated...
Activation of the STING pathway is essential for restoring immune surveillance against dormant disseminated tumor cells (DTCs) in lungs. Inhaled Mn2+ has potential as a agonist; however, its clinical application limited by risk chronic inflammation and metastasis, primarily due to reactive oxygen species (ROS) generation during inhalation. To address these risks, salvianolic acid B (salB) was identified an effective ionophore Mn2+, enhancing activation while mitigating ROS-induced...
Citrate-modified silver nanoparticles (AgNP-cit) have received extensive attention due to their excellent antimicrobial properties. However, these particles tend migrate in vivo, thereby entering the blood circulatory system granular form and accumulating liver, causing toxic reactions. mechanism underlying AgNP-cit toxicity is not yet clear. Thus, we adopted a tandem mass tag (TMT)-labeled quantitative proteomics metabolomics approach identify proteins small molecule metabolites associated...
Gout Party is a Chinese medicine prescription composed of Aconiti Lateralis Radix Praeparaia, Cocta, Cremastrae Pseudobulbus Pleiones Pseudobulbus, Smilacis Glabrae Rhizoma, Rehmanniae Radix, and Glycyrrhizae et which can relieve joint pain caused by gouty arthritis (GA) rheumatoid, has therapeutic effect on acute (AGA). However, little information available the molecular biological basis mechanism for treatment AGA. AGA model was established injecting sodium urate, colchicine served as...
Coronary heart disease (CHD) threatens human health. The discovery and assessment of potential biometabolic markers for different syndrome types CHD may contribute to decipher pathophysiological mechanisms identify new targets diagnosis treatment. On the basis UPLC-Q-TOF/MS metabolomics technology, urine samples 1072 participants from nine centers, including normal control, phlegm blood stasis (PBS) Qi Yin deficiency (QYD) syndrome, other syndromes CHD, were conducted find biomarkers. Among...
Rhubarb, as a traditional Chinese medicine, is the preferred drug for treatment of stagnation and constipation in clinical practice. It has been reported that rhubarb possesses hepatotoxicity, but its mechanism vivo still unclear.In this study, chemical components were identified based on UPLC-Q-TOF/MS combined with data postprocessing technology. The metabolic biomarkers obtained through metabolomics technology related to rhubarb-induced hepatotoxicity. Furthermore, potential targets...
The Simiao pill (SMP) is a classic prescription that has shown anti-inflammatory, analgesic, and immunomodulatory effects clinically used to treat inflammatory diseases, such as rheumatoid arthritis (RA) gouty arthritis, for which the mechanism of action remain largely unknown. In this study, serum samples from RA rats were analyzed using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry based metabolomics technology chromatography with tandem...
Current hormone-based treatments for immune thrombocytopenic purpura (ITP) are associated with potentially serious adverse reactions. Zi Dian Fang (ZDF) is a multi-target Traditional Chinese Medicine (TCM) used to treat both the symptoms and root causes of ITP, fewer side effects than treatments. This study analysis therapeutic ZDF on ITP from three aspects: platelet proliferation, immunoregulation, inflammation. After detection 52 chemical constituents by UPLC-Q-TOF/MS, The main targets...
Triptolide (TP), the main active ingredient of Tripterygium wilfordii Hook F., has great potential in treatment autoimmune diseases. However, it been found that side effects TP involve multiple organs and systems, which most serious relate to kidney. The mechanism nephrotoxicity caused by requires further investigation. In present study, we integrated proteomic metabolomic methods identify proteins small molecule metabolites associated with TP-induced nephrotoxicity. There was a significant...
Abstract Background Pulmonary tuberculosis (PTB) and lung cancer (LC) have similar clinical symptoms atypical imaging findings, which are easily misdiagnosed. There is an urgent need for a noninvasive accurate biomarker to distinguish LC from PTB. Methods A total of 694 subjects were enrolled divided into discovery set (n = 122), identification 214), validation 358). Metabolites identified by multivariate univariate analyses. Receiver operating characteristic curve used evaluate the...
Abstract Background Pao zhi is a common traditional approach that usually occurs before most herbs are prescribed whereby during processing, secondary plant metabolites transformed, thus helping to increase potency, reduce toxicity and altering their effects. Using Radix Aconiti (Chuan Wu, CW) as model herb, suitable chemical markers crucial for studying the processing mechanisms of these herbs. Results In this study, comprehensive metabolomic characters CW Prepared (ZCW) by RPLC-Q-TOF/MS...
Abstract Triptolide (TP) is one of the important active components in Tripterygium wilfordii Hook. F., which shows strong anti-inflammatory and immunomodulatory effects. However, a large number literature studies have reported that TP main component causing nephrotoxicity, mechanism nephrotoxicity has not yet been revealed. Therefore, it great practical significance to clarify toxicity TP. This study integrated network pharmacology targeted metabolomics reveal Firstly, screening 61 action...
Both Strychnos nux-vomica Linn. (SNV) and Tripterygium wilfordii Hook F (TwHF) have received extensive attention due to their excellent clinical efficacies.