A5100414443- Plant Stress Responses and Tolerance
- Lung Cancer Treatments and Mutations
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- Lung Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Photosynthetic Processes and Mechanisms
- HER2/EGFR in Cancer Research
- Plant nutrient uptake and metabolism
- Polysaccharides and Plant Cell Walls
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- Plant Gene Expression Analysis
- Natural product bioactivities and synthesis
- Plant responses to water stress
- Postharvest Quality and Shelf Life Management
- Synthesis and biological activity
- Glycosylation and Glycoproteins Research
- Plant Reproductive Biology
- Legume Nitrogen Fixing Symbiosis
- Phytochemistry and Biological Activities
- Colorectal Cancer Screening and Detection
- Aluminum toxicity and tolerance in plants and animals
Sichuan University
2014-2025
Henan Polytechnic University
2025
West China Hospital of Sichuan University
2021-2025
Jinan University
2025
Shenzhen Bay Laboratory
2025
Tongde Hospital of Zhejiang Province
2023-2024
State Ethnic Affairs Commission
2022-2024
Southwest Minzu University
2022-2024
Regend Therapeutics (China)
2024
Northwest A&F University
2020-2024
The structure−activity relationship of flavonoids as inhibitors xanthine oxidase and scavengers the superoxide radical, produced by action enzyme oxidase, was investigated. hydroxyl groups at C-5 C-7 double bond between C-2 C-3 were essential for a high inhibitory activity on oxidase. Flavones showed slightly higher than flavonols. All flavonoid derivatives except isorhamnetin (30) less active original compounds. For scavenging other hand, group C-3' in ring B essential. According to their...
Seed protein, oil content and yield are highly correlated agronomically important traits that essentially account for the economic value of soybean. The underlying molecular mechanisms selection these seed during soybean domestication are, however, less known. Here, we demonstrate a CCT gene, POWR1, underlies large-effect protein/oil QTL. A causative TE insertion truncates its domain substantially increases content, weight, while decreasing protein content. POWR1 pleiotropically controls...
This study aims to extract an active heteropolysaccharide Chia seed polysaccharide (CSP-A) and further purified by DEAE Sepharose Fast Flow CL-6B chromatographic column, characterize its structure, evaluate antioxidant immunomodulatory activities. Structural analysis revealed that CSP-A was composed of d-mannose, d-glucuronic acid d-xylose in a molar ratio 1:3:4 with molecular weight 1.688 × 105 Da, owning 4 sugar residues β-d-Manp-(1→, →4)-α-d-GlcpA-(1→, →2,4)-β-d-Xylp-(1→, → 4)-β-d-Manp-(1...
Rice (Oryza sativa) is one of the most important crops grown worldwide, and saline-alkali stress seriously affects yield quality rice. It imperative to elucidate molecular mechanisms underlying rice response stress. In this study, we conducted an integrated analysis transcriptome metabolome effects long-term on High (pH > 9.5) induced significant changes in gene expression metabolites, including 9347 differentially expressed genes (DEGs) 693 accumulated metabolites (DAMs). Among DAMs, lipids...
Drought is a major environmental threat that limits crop growth, development, and productivity worldwide. Improving drought resistance with genetic engineering methods necessary to tackle global climate change. It well known NAC (NAM, ATAF CUC) transcription factors play critical role in coping stress plants. In this study, we identified an factor ZmNAC20, which regulates response maize. ZmNAC20 expression was rapidly upregulated by abscisic acid (ABA). Under conditions, the...
Ligand-dependent interactions between nuclear receptors and members of a family receptor coactivators are associated with transcriptional activation. Here we used fluorescence resonance energy transfer (FRET) as an approach for detecting quantitating such interactions. Using the ligand binding domain (LBD) peroxisome proliferator-activated (PPARgamma) model, known agonists (thiazolidinediones delta12, 14-PGJ2) induced specific interaction resulting in FRET fluorescently labeled LBD...
Ligand-induced endocytosis and lysosomal degradation of cognate receptors regulate the extent cell signaling. Along with linear endocytic motifs that recruit adaptin protein complex 2 (AP2)-clathrin molecules, monoubiquitination has emerged as a major signal. By investigating ubiquitin-dependent interferon (IFN)-alpha/beta receptor 1 (IFNAR1) subunit type I IFN receptor, we reveal IFNAR1 is polyubiquitinated via both Lys48- Lys63-linked chains. The SCF(betaTrcp) (Skp1-Cullin1-F-box complex)...
Abstract The phytohormone abscisic acid (ABA) plays a vital role in plant growth and development. function of ABA is mediated by group newly discovered receptors, named PYRABACTIN RESISTANCE 1/PYR‐LIKE/REGULATORY COMPONENTS OF RECEPTORs (PYR1/PYLs/RCARs). Here, we report that an Arabidopsis thaliana F‐box protein RCAR3 INTERACTING F‐BOX PROTEIN 1 (RIFP1) interacts with receptor (RCAR3) SCF E3 ligase complex subunits SKP1‐LIKE PROTEINs (ASKs) vitro vivo . rifp1 mutant plants displayed...
The function of abscisic acid (ABA) is mediated by its receptors termed RCARs/PYR1/PYLs. Modulation ABA signaling vital for plant growth and development. RCAR-PP2C-SnRK2 regulatory modules have been defined as the core components in signaling. However, it still not clear whether how could be modified at initial post-translational stage to fine-tune transduction pathway. Here we identify characterize putative receptor-like cytoplasmic kinase (RLCK) Arabidopsis named CARK1, which interacts...
Silicosis resulting from silica exposure is a global occupational disease characterized by severe pathological changes in progressive pulmonary fibrosis. Previous evidence has indicated that dysbiosis of the gut microbiota occurs after environmental dust and associated with certain diseases. The aims this study are to elucidate compositional functional characteristics early-stage silicosis understand their influence on We investigated microbial composition fecal samples 18 patients 21...
Abstract The phytohormone ethylene is well known for its important role in the ripening of climacteric fruit, such as tomato (Solanum lycopersicum). However, and mode action other plant hormones fruit regulation are not fully understood. Here, we showed that exogenous GA treatment or increasing endogenous gibberellin content by overexpressing synthesis gene SlGA3ox2 specifically tissues delayed ripening, whereas with biosynthesis inhibitor paclobutrazol (PAC) accelerated ripening. Moreover,...
Cotton is one of the most important natural fibers used in textile industry worldwide. It to identify key factors involved cotton fiber development. In this study, zinc finger protein8 (GhZFP8) encoding a C2H2 transcription factor (TF) was cloned from cotton. qPCR showed that transcripts GhZFP8 were detected leaves and at 3, 6, 30 days post-anthesis (DPA), but not roots, stems, or flowers. The overexpression increased trichome number on siliques, leaves, inflorescence, inhibited growth....
Introduction Abiotic stress during growth readily reduces cotton crop yield. The different survival tactics of plants include the activation numerous response genes, such as BREVIS RADIX ( BRX ). Methods In this study, gene family upland was identified and analyzed by bioinformatics method, three salt-tolerant cold-resistant GhBRX genes were screened. expression GhBRX.1 , GhBRX.2 GhBRXL4.3 in silenced virus-induced silencing (VIGS) technique. physiological biochemical indexes related...
The phytohormone abscisic acid (ABA) regulates plant growth, the developmental process, and abiotic stresses. ABA signaling is induced in response to mediate acclimation environmental challenges, including high salinity drought. ABA-binding receptors (RCAR/PYR1/PYL), composing of 14 members, are core components ABA-signaling pathway. Here, we observed that three subfamilies within RCARs showed different expression patterns at basal exogenous levels. Subsequently, generated transgenic plants...
The rice blast fungus Magnaporthe oryzae generates infection structure appressoria in response to surface cues largely due functions of signaling molecules, including G-proteins, regulators G-protein (RGS), mitogen-activated protein (MAP) kinase pathways, cAMP signaling, and TOR pathways. M. encodes eight RGS RGS-like proteins (MoRgs1 MoRgs8), MoRgs1, MoRgs3, MoRgs4, MoRgs7 were found be particularly important appressorium development. To explore the mechanisms by which these regulate...
Management of PD-1 blockade resistance in metastatic melanoma (MM) remains challenging. Immunotherapy or chemotherapy alone provides limited benefit this setting. Chemo-immunotherapy (CIT) has demonstrated favorable efficacy and safety profiles lung cancer. Our pre-clinical study showed that MM patients who have failed blockade, the addition increases CX3CR1+ therapy-responsive CD8+ T-cells with enhanced anti-tumor activity, resulting improved clinical response. Here, we examined outcomes...
Abstract Gibberellins (GAs) play crucial roles in a wide range of developmental processes and stress responses plants. However, the GA-responsive genes tomato (Solanum lycopersicum) fruit development remain largely unknown. Here, we identify 17 GASA (Gibberellic Acid-Stimulated Arabidopsis) family tomato. These encode proteins with cleavable signal peptide at their N terminus conserved domain C terminus. The expression levels all were responsive to exogenous GA treatment, but adding ethylene...