A5084892136- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Essential Oils and Antimicrobial Activity
- Bacterial biofilms and quorum sensing
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Insect Pest Control Strategies
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Antimicrobial Peptides and Activities
- Antifungal resistance and susceptibility
- Phytochemicals and Antioxidant Activities
- Fungal Biology and Applications
- Parasites and Host Interactions
- Malaria Research and Control
- Cancer therapeutics and mechanisms
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Phytochemistry and Bioactivity Studies
- Free Radicals and Antioxidants
- Toxin Mechanisms and Immunotoxins
- Antimicrobial agents and applications
- Mycobacterium research and diagnosis
- Ethnobotanical and Medicinal Plants Studies
- Antimicrobial Resistance in Staphylococcus
University of Antwerp
2016-2025
Institute of Medical Microbiology and Hygiene
2024
Provincial Institute for Hygiene
2022-2024
Amberton University
2024
ORCID
2022
Ministère de la Santé et de l'Hygiène Publique
2016-2019
Research Network (United States)
2019
Province of Antwerp
2018
John Wiley & Sons (United Kingdom)
2017
GTx (United States)
2016
The structure−activity relationship of flavonoids as inhibitors xanthine oxidase and scavengers the superoxide radical, produced by action enzyme oxidase, was investigated. hydroxyl groups at C-5 C-7 double bond between C-2 C-3 were essential for a high inhibitory activity on oxidase. Flavones showed slightly higher than flavonols. All flavonoid derivatives except isorhamnetin (30) less active original compounds. For scavenging other hand, group C-3' in ring B essential. According to their...
ABSTRACT Although the exact role of quorum sensing (QS) in various stages biofilm formation, maturation, and dispersal resistance is not entirely clear, use QS inhibitors (QSI) has been proposed as a potential antibiofilm strategy. We have investigated whether QSI enhance susceptibility bacterial biofilms to treatment with conventional antimicrobial agents. The used our study target acyl-homoserine lactone-based system present Pseudomonas aeruginosa Burkholderia cepacia complex organisms...
Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPIV). It has been convincingly linked multiple disease states involving remodeling of the extracellular matrix. FAP inhibition investigated as therapeutic option for several these diseases, with most attention so far devoted oncology applications. We previously discovered N-4-quinolinoyl-Gly-(2S)-cyanoPro scaffold possible entry highly potent and selective inhibitors. In present study, we explore...
Abstract Breakthroughs in cancer immunotherapies have demonstrated considerable success, though not without limitations. Non‐thermal plasma (NTP) for therapy has been emerging as a potential adjuvant treatment via induction of immunogenic cell death (ICD). Cancer cells undergoing ICD stimulate patient's immune system to mount an anticancer response. While promising, the underlying mechanisms NTP‐induced must be closely examined. Here, interaction between non‐thermal and cancerous is studied....
Fibroblast activation protein (FAP) is a serine protease that generally accepted to play an important role in tumor growth and other diseases involving tissue remodeling. Currently there are no FAP inhibitors with reported selectivity toward both the closely related dipeptidyl peptidases (DPPs) prolyl oligopeptidase (PREP). We present discovery of new class N-(4-quinolinoyl)-Gly-(2-cyanopyrrolidine) scaffold. have explored effects substituting quinoline ring varying position its sp(2)...
Background Chronic airway inflammation is the main driver of pathogenesis in respiratory diseases such as severe asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF) and bronchiectasis. While role common pathogens widely recognised, influence other microbiota members still poorly understood. Methods We hypothesised that lung contains bacteria with immunomodulatory activity which modulate net levels immune activation by key pathogens. Therefore, we assessed effect several...
The in vitro susceptibilities of the reference strain Leishmania donovani MHOM/ET/67/L82 to sodium stibogluconate, amphotericin B, miltefosine, and experimental compound PX-6518 were determined for extracellular log-phase promastigotes, established axenic amastigotes, fresh spleen-derived intracellular amastigotes primary mouse peritoneal macrophages. Susceptibility B did not differ across various models (50% inhibitory concentrations [IC50], 0.6 0.7 microM), showed slightly higher potency...
ABSTRACT Bacteria and matrix are essential for the development of biofilms, assays should therefore target both components. The current European guidelines biocidal efficacy testing not adequate sessile microorganisms; hence, alternative discriminatory test protocols be used. activities a broad range biocides on Staphylococcus aureus Pseudomonas aeruginosa biofilms were evaluated using such in vitro assays. Nearly all selected showed significant decrease S. biofilm viability, with sodium...
Background Many bacteria, including Vibrio spp., regulate virulence gene expression in a cell-density dependent way through communication process termed quorum sensing (QS). Hence, interfering with QS could be valuable novel antipathogenic strategy. Cinnamaldehyde has previously been shown to inhibit QS-regulated by decreasing the DNA-binding ability of response regulator LuxR. However, little is known about structure-activity relationship cinnamaldehyde analogs. Methodology/Principal...
Background During normal pregnancy, placental oxidative stress (OS) is present during all three trimesters and necessary to obtain cell function. However, if OS reaches a certain level, pregnancy complications might arise. In preeclampsia (PE), dangerous specific hypertensive disorder, induced in the ischemic placenta causes systemic inflammatory response activates maternal endothelial cells. this study, we aimed quantify superoxide concentrations (as measure of OS) using electron...
Summary A number of clinical studies have shown protective effects lactobacilli against Candida species in the gastrointestinal tract, urogenital tract and oral cavity, while others did not show clear effects. Evidence on mode action is also still lacking. In this study, anti‐ activity model probiotic strain Lactobacillus rhamnosus GG was explored different assays to determine molecular interactions. We found that L. able interfere with growth, morphogenesis adhesion. These three aspects 's...
It was recently proposed that bactericidal antibiotics, besides through specific drug-target interactions, kill bacteria by a common mechanism involving the production of reactive oxygen species (ROS). However, this hydroxyl radicals has become subject lot debate. Since contribution ROS to antibiotic mediated killing most likely depends on conditions, differences in experimental procedures are expected be at basis conflicting results. In present study different methods (ROS stainings,...
During the last decade miltefosine (MIL) has been used as first-line treatment for visceral leishmaniasis in endemic areas with antimonial resistance, but a decline clinical effectiveness is now being reported. While only two MIL-resistant Leishmania infantum strains from HIV co-infected patients have documented, phenotypic MIL-resistance L. donovani not yet identified laboratory. Hence, better understanding of factors contributing to increased MIL-treatment failure necessary. Given paucity...