A5004515034- Malaria Research and Control
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Viral Infections and Vectors
- Parasitic Diseases Research and Treatment
- Toxin Mechanisms and Immunotoxins
- Synthesis and Biological Evaluation
- Insect Pest Control Strategies
- Ethics in medical practice
- Genetics, Bioinformatics, and Biomedical Research
- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Drug-Induced Hepatotoxicity and Protection
- Viral Infections and Outbreaks Research
- Food Security and Health in Diverse Populations
- HIV/AIDS Impact and Responses
- Paraoxonase enzyme and polymorphisms
- Parasitic Infections and Diagnostics
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Amoebic Infections and Treatments
Instituut voor Tropische Geneeskunde
2017-2025
University of Antwerp
2010-2019
Gouverneur Kinsbergencentrum
2017
University of Kinshasa
2015
The in vitro susceptibilities of the reference strain Leishmania donovani MHOM/ET/67/L82 to sodium stibogluconate, amphotericin B, miltefosine, and experimental compound PX-6518 were determined for extracellular log-phase promastigotes, established axenic amastigotes, fresh spleen-derived intracellular amastigotes primary mouse peritoneal macrophages. Susceptibility B did not differ across various models (50% inhibitory concentrations [IC50], 0.6 0.7 microM), showed slightly higher potency...
<ns4:p>Background Coordinated efforts in the control of gambiense human African trypanosomiasis (gHAT) have significantly reduced its endemicity. WHO targets interruption transmission by 2030. However, challenges remain, including low sensitivity current parasitological confirmation tests, leaving a potential reservoir untreated. Acoziborole, single-dose oral treatment, effective both disease stages with good safety profile, offers treatment parasitologically negative gHAT seropositive...
In areas of high malaria transmission, Plasmodium falciparum infection during pregnancy is characterized by malaria-related anaemia, placental and does not always result in clinical symptoms. This situation associated with poor outcomes. The aim this study was to determine the extent asymptomatic P. infection, its relation anaemia as well most cost-effective technique for diagnosis healthy pregnant women living Kinshasa, Democratic Republic Congo.In a cross-sectional design, information on...
ABSTRACT Diagnostic material from patients with leishmaniasis is generally available as promastigotes, and proper testing for susceptibility to first-line drugs by the intracellular amastigote assay frequently hampered poor infectivity of promastigotes macrophage host cell. Several conditions optimization in vitro metacyclogenesis cell Leishmania donovani , L. guyanensis braziliensis field strains obtained receiving standard antimony medication were investigated. Triggering log-phase become...
Background Pathogens causing acute fever, with the exception of malaria, remain largely unidentified in sub-Saharan Africa, given local unavailability diagnostic tests and broad differential diagnosis. Methodology We conducted a cross-sectional study including outpatient undifferentiated fever both children adults, between November 2015 June 2016 Kinshasa, Democratic Republic Congo. Serological molecular for selected arboviral infections were performed on blood, PCR, NS1-RDT, ELISA IFA...
Background Anaemia reduces cognitive potential in school children, retards their growth and predisposes them to other diseases. As there is a paucity of data on the current burden P. falciparum, S. mansoni soil transmitted helminths (STH) infections correlation with schoolchildren's anemia Democratic Republic Congo (DRC), we collect these data. Methods This study reports baseline collected from randomized controlled trial investigating impact IPT SP SP-PQ malaria morbidity Congolese...
Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in India. Although no clinical resistance yet reported, proactive vigilance should be warranted. The present vitro study compared the outcome and stability experimental PMM-resistance induction on promastigotes intracellular amastigotes. Cloned antimony-resistant L. donovani field isolates from India Nepal were exposed to stepwise increasing concentrations PMM (up 500 µM), either as or One resulting...
Malaria is preventable and treatable when recommended interventions are properly implemented. Thus, diagnosis treatment focus on symptomatic individuals while asymptomatic Plasmodium infection (PI) plays a role in the sustainability of transmission may also have an impact morbidity disease terms anaemia, nutritional status even cognitive development children. The objective this study was to assess PI prevalence its relationship with known factors vulnerable but stratum population. A simple...
Background Socio-cultural and economic factors constitute real barriers for uptake of screening treatment Human African Trypanosomiasis (HAT) in the Democratic Republic Congo (DRC). Better understanding addressing these may enhance effectiveness HAT control. Methods We performed a qualitative study consisting semi-structured interviews focus group discussions Bandundu Kasaï Oriental provinces, two provinces lagging behind elimination effort. Our population included current former patients,...
Abstract Maesa saponins with the 13,28‐epoxy‐oleanane triterpene core skeleton were described recently to possess strong and selective in vitro vivo antileishmania activity. In absence of direct chemical derivatization possibilities, a structure‐based literature search was carried out explore structure‐activity relationship. Crude alcohol extracts from several plant species Myrsinaceae, Primulaceae, Aceraceae Icacinaceae evaluated for activity against Leishmania infantum intracellular...
School-aged children suffer the most from schistosomiasis infection in sub Saharan Africa due to poverty and limited sanitary conditions. Mapping of disease burden is recommended there a need updating prevalence data which as old 20 years Democratic Republic Congo. An epidemiological parasitological study was carried out 2011 health zone Kasansa. Six areas (HA) were included study. In each area, one primary school selected. screened for S. mansoni using parallel Kato-Katz direct microscopy...
The Democratic Republic of the Congo (DRC) is one five countries carrying half global malaria burden with children 0–5 years old being most at risk. Rapid diagnostic tests (RDTs) are currently routinely used for detection Plasmodium infection in health centres and may be a useful tool population-based survey. This study assessed, stable transmission zone Kinshasa, whether HRP2-based RDT matches selection criteria National Malaria Control Programme (NMCP), DRC assessed relevant fever...
Abstract In medical research, the ethical principle of respect for persons is operationalized into process informed consent. The consent tools should be contextualized and adapted to different socio‐cultural environment, especially when research crosses traditional boundaries reaches poor communities. We look at challenges experienced in malaria Quinact trial, conducted D emocratic R epublic C ongo, describe some lessons learned, related definition acceptable representative, role independent...
Artemisinin-based combination therapy (ACT) following a confirmed parasitological diagnosis is recommended by the World Health Organization (WHO) and Congolese National Malaria Control Program (NMCP). However, commitment competence of all stakeholders (patients, medical professionals, governments funders) required to achieve effective case management secure "useful therapeutic life" drugs. The health seeking behaviour patients care professionals' practices for malaria were assessed.This was...
Quinine or alternative artemisinin-based combination treatment (ACT) is the recommended rescue for uncomplicated malaria. However, patients are often re-treated with same ACT though it unclear whether this most suitable approach. We assessed efficacy and safety of re-treating malaria failures used primary episode, compared other treatments.This was a bicentre, open-label, randomised, three-arm phase 3 trial done in Lisungi health centre DR Congo, Kazo Uganda 2012-14. Children aged 12-60...
Background In the Democratic Republic of Congo, artesunate-amodiaquine (ASAQ) is first-line medication recommended for uncomplicated malaria treatment. We conducted a study in Kinshasa to describe clinical features disease and assess efficacy ASAQ its impact on multiplicity infection children with malaria. Methods Children aged 12 59 months P. falciparum were treated followed up passively 42 days. To distinguish new infections from recrudescent parasites, samples genotyped using stepwise...
In recent years, the number of reported Human African Trypanosomiasis (HAT) cases caused by Trypanosoma brucei (T . b ) gambiense has been markedly declining, and goal ‘elimination as a public health problem’ is within reach. For next stage, i.e. interruption HAT transmission 2030, intensive screening surveillance will need to be maintained, but with tools strategies more efficiently tailored very low prevalence. We assessed sequential use ELISA Immune Trypanolysis (ITL) on dried blood spot...
In Democratic Republic of Congo access to health care is limited because many geographical and financial barriers, while quality often low. Global donors assist the country with a number community-oriented interventions such as free distribution bednets, antihelminthic drugs, vitamin A supplementation vaccination campaigns, but uptake these not always optimal. The aim this study was explore perceptions poor urban communities capital Kinshasa regard issues in general well their experiences...
Schistosomiasis (SCH) is an important public health problem in developing countries and school-aged children are the most affected. This study explored nutritional status their correlation with SCH attending primary school (3rd to 6th class) living area of Kasansa Democratic Republic Congo.Across-sectional household survey was carried out February 2011. Children whose parents reported attend were included. Socio-demographic characteristics, information on morbidity history risk factor...
The oleanane triterpene saponin PX-6518, with known potent in vitro and vivo activity against Leishmania donovani, was investigated for its spectrum the cutaneous species mexicana, panamensis major. In based on reduction of amastigotes primary peritoneal mouse macrophages. BALB/c mice were injected 2 × 106 base tail (L. L. major) or foot mexicana) subcutaneously treated PX-6518 [1–10 mg/kg body weight (BW)] Pentostam® (250 BW SbV eq). Evolution skin lesions monitored a prophylactic...