A5030878686- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Lysosomal Storage Disorders Research
- Heart Failure Treatment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Mechanical Circulatory Support Devices
- Synthesis and Biological Evaluation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- HIV/AIDS drug development and treatment
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Peripheral Neuropathies and Disorders
- Cardiac Ischemia and Reperfusion
- Chemotherapy-related skin toxicity
- Pharmacological Effects and Assays
- Memory and Neural Mechanisms
- Carbohydrate Chemistry and Synthesis
Drugs for Neglected Diseases Initiative
2014-2023
Scherrer (Switzerland)
2022
Kinshasa General Hospital
2022
University of Florida
2017
Columbus Oncology and Hematology Associates
2017
Reckitt Benckiser (United States)
2017
Paris Biotech Santé
2003-2007
Human Technopole
2003
Novartis (France)
1997
Centre Hospitalier Universitaire Henri-Mondor
1993
<h2>Summary</h2><h3>Background</h3> Human African trypanosomiasis caused by <i>Trypanosoma brucei gambiense</i> (gambiense HAT) in patients with late-stage disease requires hospital admission to receive nifurtimox–eflornithine combination therapy (NECT). Fexinidazole, the latest treatment that has been recommended WHO, also systematic hospital, which is problematic areas few health-care resources. We aim assess safety and efficacy of acoziborole adult adolescent gambiense HAT....
<ns4:p>Background Coordinated efforts in the control of gambiense human African trypanosomiasis (gHAT) have significantly reduced its endemicity. WHO targets interruption transmission by 2030. However, challenges remain, including low sensitivity current parasitological confirmation tests, leaving a potential reservoir untreated. Acoziborole, single-dose oral treatment, effective both disease stages with good safety profile, offers treatment parasitologically negative gHAT seropositive...
Fexinidazole is a 5-nitroimidazole recently included in clinical efficacy trial as an oral drug for the treatment of human African trypanosomiasis (HAT). Preclinical studies showed it acts pharmacologically active pro-drug with two key metabolites: sulfoxide and sulfone (the most metabolite). The present aimed to determine best dose regimen stage 2 sleeping sickness patients, which could eventually also treat 1 patients.Fexinidazole was assessed 154 healthy adult male subjects sub-Saharan...
Staging and treatment of human African trypanosomiasis caused by Trypanosoma brucei gambiense (g-HAT) required lumbar puncture to assess cerebrospinal fluid (CSF) intravenous drugs that cross the blood-brain barrier for late-stage infection. These procedures are inconvenient in rural health systems disease-endemic countries. A pivotal study established fexinidazole as first oral monotherapy be effective against non-severe stage 2 g-HAT. We aimed safety efficacy early
Avibactam is a non-β-lactam β-lactamase inhibitor intended for use as fixed-dose combination with ceftazidime the treatment of certain serious Gram-negative infections. As avibactam primarily excreted unchanged in urine, renal impairment may affect its pharmacokinetics. This phase 1 study investigated effect and hemodialysis on pharmacokinetics safety. Healthy controls subjects increasing degrees received single 30-minute intravenous (IV) infusion (100 mg). Anuric requiring same pre-...
In this article, the authors show strategy used to streamline introduction of fexinidazole, first all oral treatment human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense. The dose range was determined in phase 1 studies and a significant food effect observed, which tested with field-adapted meals. pharmacokinetic profile required definition higher loading dosage for 4 days administration daily together typical local meal optimize product absorption rapidly achieve drug...
Acoziborole is a novel boron-containing candidate developed as an oral drug for the treatment of human African trypanosomiasis (HAT). Results from preclinical studies allowed progression to Phase 1 trials. We aimed determine best dose regimen all stages HAT. was assessed in 128 healthy adult males sub-Saharan origin living France. The study included single administration 20- 1200-mg randomised double-blind cohorts 8 (6 active, 2 placebo) assess safety, tolerability, and pharmacokinetics. In...
A single dose of 6 mg/kg teicoplanin was infused over 10 min in six children mean age 7 years, and a 20 four neonates 8.5 days. Serum sampling performed at 0 1, 4, 12 24 h thereafter 24-hourly, up to ten Urine collected for each throughout the study children. Teicoplanin assayed by high performance liquid chromatography. Tolerability excellent both neonates. For all patients serum concentrations followed an open two-compartment model. Mean Cmax 48.6 +/- 16.7 mg/l (10 min) children, 19.6 1.05...
Fexinidazole is a novel oral treatment for human African trypanosomiasis caused by Trypanosoma brucei gambiense (g-HAT). also has activity against T. cruzi, the causative agent of Chagas disease. During course dose ranging assessment in patients with chronic indeterminate disease, delayed neutropenia and significant increases hepatic transaminases were observed clinical investigations suspended. We retrospectively analyzed all available pharmacokinetic pharmacodynamic data on fexinidazole...
A series of clinical pharmacology studies was performed to screen for possible pharmacokinetic/dynamic contributions drug interactions reported in rheumatoid arthritis patients receiving cyclosporine and nonsteroidal antiinflammatory drugs (NSAIDs). No clinically relevant pharmacokinetic changes any the were noted when single‐dose coadministered during a steady‐state regimen aspirin, indomethacin, or piroxicam healthy volunteers. Only with diclofenac an interaction observed whereby area...
Teicoplanin, a new glycopeptide antibiotic belonging to the same class as vancomycin, is mixture of six main components, designated A3, A2-1, A2-2, A2-3, A2-4 and A2-5. An assay method by higher performance liquid chromatography (HPLC) has been devised separate monitor each these components in blood urine.
From September 1985 to August 1988, 32 patients were referred from various intensive care units throughout Paris for urgent cardiac transplantation or a mechanical bridge transplantation. At time of admission, under maximal sympathomimetic therapy, the index (CI) was 1.81 +/- 0.26 l/min per m2, pulmonary capillary wedge pressure (PCWP 31 7 mmHg), systemic vascular resistances (SVR) 2053 469 dynes s cm-5. In 25, diuresis less than 25 ml/h. Five anuric. Prior any final decision, new inotropic...
Developing countries face numerous barriers to conducting effective and efficient ethics reviews of international collaborative research. In addition potentially overlooking important scientific ethical considerations, inadequate or insufficiently trained committees may insist on unwarranted changes protocols that can impair a study's validity. Moreover, poorly functioning review systems impose substantial delays the commencement research, which needlessly undermine development new...
Background Spliced Leader (SL) trypanosome RNA is detectable only in the presence of live trypanosomes, abundant and Trypanozoon subgenus has a unique sequence. As previously shown blood from Guinean human African trypanosomiasis (HAT) patients, SL-RNA an accurate target for diagnosis. Detection cerebrospinal fluid (CSF) never been attempted. In large group Congolese gambiense HAT present study aims i) to confirm sensitivity detection and; ii) assess diagnostic performance compared CSF....