A5080516970- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Infant Nutrition and Health
- Infant Development and Preterm Care
- Gestational Diabetes Research and Management
- Child Nutrition and Feeding Issues
- Child Nutrition and Water Access
- Neuroscience of respiration and sleep
- Health, Medicine and Society
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Metabolism and Genetic Disorders
- Breastfeeding Practices and Influences
- Neonatal Health and Biochemistry
- Epigenetics and DNA Methylation
- Child and Adolescent Health
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Renal and related cancers
- Clinical Nutrition and Gastroenterology
- Obesity, Physical Activity, Diet
- Adipose Tissue and Metabolism
- Organ Transplantation Techniques and Outcomes
- Ethics and Legal Issues in Pediatric Healthcare
University of Lausanne
2016-2025
University Hospital of Lausanne
2015-2024
Inserm
2001-2020
Université Paris Cité
2013-2020
Institut de Recherche pour le Développement
2020
University of Florence
2020
Ospedale di Livorno
2020
Terra
2020
University of Ferrara
2000-2019
Hôpital Orthopédique de la Suisse Romande
2015-2018
As management of respiratory distress syndrome (RDS) advances, clinicians must continually revise their current practice. We report the fourth update "European Guidelines for Management RDS" by a European panel experienced neonatologists and an expert perinatal obstetrician based on available literature up to end 2018. Optimising outcome babies with RDS includes prediction risk preterm delivery, need appropriate maternal transfer centre timely use antenatal steroids. Delivery room has become...
<h3>Importance</h3> Up-to-date estimates of the health outcomes preterm children are needed for assessing perinatal care, informing parents, making decisions about and providing evidence clinical guidelines. <h3>Objectives</h3> To determine survival neonatal morbidity infants born from 22 through 34 completed weeks’ gestation in France 2011 compare these with a comparable cohort 1997. <h3>Design, Setting, Participants</h3> The EPIPAGE-2 study is national, prospective, population-based...
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report updated recommendations a European Panel expert neonatologists who developed consensus guidelines after critical examination most up-to-date evidence 2007 and 2010. This second update is based upon published up to end 2012. Strong exists for role antenatal steroids RDS prevention, but it not clear if benefit repeated courses on outcomes outweighs risk...
Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report third update European Guidelines for Management RDS by a panel expert neonatologists including input from an perinatal obstetrician based on available literature up beginning 2016. Optimizing outcome babies with includes consideration when use antenatal steroids, and good obstetric practice methods predicting risk preterm delivery also whether transfer...
Respiratory distress syndrome (RDS) care pathways evolve slowly as new evidence emerges. We report the sixth version of "European Guidelines for Management RDS" by a panel experienced European neonatologists and an expert perinatal obstetrician based on available literature up to end 2022. Optimising outcome babies with RDS includes prediction risk preterm delivery, appropriate maternal transfer centre, timely use antenatal steroids. Evidence-based lung-protective management initiation...
Early surfactant followed by extubation to nasal continuous positive airway pressure (nCPAP) compared with later and mechanical ventilation (MV) reduce the need for MV, air leaks, bronchopulmonary dysplasia. This randomized, controlled trial investigated whether prophylactic nCPAP early application selective would MV in first 5 days of life.A total 208 inborn infants who were born at 25 28 weeks' gestation not intubated birth randomly assigned or within 30 minutes birth. Outcomes assessed...
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report updated recommendations a European panel expert neonatologists who had developed consensus guidelines after critical examination most up-to-date evidence 2007. These are based upon published up to end 2009. Strong exists for role single course antenatal steroids RDS prevention, but potential benefit and long-term safety repeated courses unclear. Many...
Context Supplementation of breast milk is difficult once infants suckle the and often discontinued at end hospitalisation after discharge. Thus, breastfed preterm are exposed to an increased risk nutritional deficit with a possible consequence on neurodevelopmental outcome. Objective To assess relationship between feeding time discharge, weight gain during Design Observational cohort study. Setting Two large, independent population-based cohorts very infants: Loire Infant Follow-up Team...
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report recommendations a European panel expert neonatologists who developed consensus guidelines after critical examination most up-to-date evidence 2007. Strong exists for role antenatal steroids RDS prevention, but it is not clear if repeated courses are safe. Many practices involved preterm stabilization at birth based, including oxygen administration and...
Background. Necrotizing enterocolitis (NEC) is the most common and serious gastrointestinal disorder among preterm neonates. We aimed to assess a specific gut microbiota profile associated with NEC.
Preeclampsia (PE) is a common human-specific pregnancy disorder defined by hypertension and proteinuria during gestation responsible for maternal fetal morbimortality. STOX1 , encoding transcription factor, was the first gene associated with PE as identified positional cloning approaches. Its overexpression in choriocarcinoma cells mimics transcriptional consequences of human placenta. Here, we created transgenic mouse strains overexpressing . Wild-type female mice crossed male reproduce...
Intrauterine growth restriction (IUGR) affects 10-15% of all pregnancies worldwide. IUGR may result from maternal, placental or fetal origin. Maternal malnutrition before and during pregnancy represents the most prevalent non-genetic cause. reflects an abnormal adaptive in a deleterious environment. Individuals born after are more susceptible to develop diseases related subsequent stressors through lifetime. Animal models help decipher underlying causes dysregulated pathways molecular...
Genomic imprinting characterizes genes with a monoallelic expression, which is dependent on the parental origin of each allele. Approximately 150 imprinted are known to date, in humans and mice but, though computational searches have tried extract intrinsic characteristics these identify new ones, existing list probably far from being comprehensive. We used high-throughput strategy by diverting classical use genotyping microarrays compare genotypes mRNA/cDNA vs. genomic DNA presenting...