A5070985495- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Neonatal Health and Biochemistry
- Child and Adolescent Health
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Fatty Acid Research and Health
- Birth, Development, and Health
- Airway Management and Intubation Techniques
- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Biochemical Analysis and Sensing Techniques
- Neonatal skin health care
- Pediatric health and respiratory diseases
- Material Properties and Processing
- Surfactants and Colloidal Systems
- Cardiovascular Conditions and Treatments
- Thyroid Disorders and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
- ATP Synthase and ATPases Research
- Blood groups and transfusion
- Porphyrin Metabolism and Disorders
Charles University
2015-2025
General University Hospital in Prague
2010-2025
RELX Group (United States)
2022
Academic Pediatric Association
2022
Leiden University Medical Center
2021
Georgetown University
2003
Ocní klinika
2000
As management of respiratory distress syndrome (RDS) advances, clinicians must continually revise their current practice. We report the fourth update "European Guidelines for Management RDS" by a European panel experienced neonatologists and an expert perinatal obstetrician based on available literature up to end 2018. Optimising outcome babies with RDS includes prediction risk preterm delivery, need appropriate maternal transfer centre timely use antenatal steroids. Delivery room has become...
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report updated recommendations a European Panel expert neonatologists who developed consensus guidelines after critical examination most up-to-date evidence 2007 and 2010. This second update is based upon published up to end 2012. Strong exists for role antenatal steroids RDS prevention, but it not clear if benefit repeated courses on outcomes outweighs risk...
Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report third update European Guidelines for Management RDS by a panel expert neonatologists including input from an perinatal obstetrician based on available literature up beginning 2016. Optimizing outcome babies with includes consideration when use antenatal steroids, and good obstetric practice methods predicting risk preterm delivery also whether transfer...
Respiratory distress syndrome (RDS) care pathways evolve slowly as new evidence emerges. We report the sixth version of "European Guidelines for Management RDS" by a panel experienced European neonatologists and an expert perinatal obstetrician based on available literature up to end 2022. Optimising outcome babies with RDS includes prediction risk preterm delivery, appropriate maternal transfer centre, timely use antenatal steroids. Evidence-based lung-protective management initiation...
Early surfactant followed by extubation to nasal continuous positive airway pressure (nCPAP) compared with later and mechanical ventilation (MV) reduce the need for MV, air leaks, bronchopulmonary dysplasia. This randomized, controlled trial investigated whether prophylactic nCPAP early application selective would MV in first 5 days of life.A total 208 inborn infants who were born at 25 28 weeks' gestation not intubated birth randomly assigned or within 30 minutes birth. Outcomes assessed...
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report updated recommendations a European panel expert neonatologists who had developed consensus guidelines after critical examination most up-to-date evidence 2007. These are based upon published up to end 2009. Strong exists for role single course antenatal steroids RDS prevention, but potential benefit and long-term safety repeated courses unclear. Many...
Systemic glucocorticoids reduce the incidence of bronchopulmonary dysplasia among extremely preterm infants, but they may compromise brain development. The effects inhaled on outcomes in these infants are unclear.
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report recommendations a European panel expert neonatologists who developed consensus guidelines after critical examination most up-to-date evidence 2007. Strong exists for role antenatal steroids RDS prevention, but it is not clear if repeated courses are safe. Many practices involved preterm stabilization at birth based, including oxygen administration and...
The long-term effects on neurodevelopment of the use inhaled glucocorticoids in extremely preterm infants for prevention or treatment bronchopulmonary dysplasia are uncertain.
<h3>Objective</h3> CHF5633 (Chiesi Farmaceutici S.p.A., Parma, Italy) is the first fully synthetic surfactant enriched by peptide analogues of <i>two</i> human proteins. We planned to assess safety and tolerability explore preliminary efficacy. <h3>Design</h3> Multicentre cohort study. <h3>Patients</h3> Forty infants from 27<sup>+0</sup> 33<sup>+6</sup> weeks gestation with respiratory distress syndrome requiring fraction inspired oxygen (FiO<sub>2</sub>) ≥0.35 were treated a single dose...
Applying a mask on the face for respiratory support could induce trigeminocardiac reflex leading to apnoea and bradycardia. We have examined effect of applying breathing heart rate in preterm infants at birth.Resuscitation videos ≤ 32 weeks gestation recorded from 2010 until 2018 Leiden University Medical Centre General Hospital Prague were reviewed. All received via mask. Breathing noted before after application over first 5 min.Recordings 429 included (median (IQR) gestational age 28+6...
ObjectiveTo investigate the efficacy and safety of nebulized poractant alfa (at 200 400 mg/kg doses) delivered in combination with nasal continuous positive airway pressure compared alone premature infants diagnosed respiratory distress syndrome.Study designThis randomized, controlled, multinational study was conducted at 280/7 to 326/7 weeks gestation. The primary outcome incidence failure first 72 hours life, defined as needing endotracheal surfactant and/or mechanical ventilation owing...
Objective Regarding the use of lung ultrasound (LU) in neonatal intensive care units (NICUs) across Europe, to assess how widely it is used, for what indications and its implementation might be improved. Design intervention International online survey. Results Replies were received from 560 NICUs 24 countries between January May 2023. LU uptake varied considerably (20%–98% NICUs) countries. In 428 (76%), was used clinical indications, while 34 (6%) only research purposes. One-third had <2...
inflammatory properties, and early inhalation of corticosteroids may provide beneficial local effects on the lungs prior to development a full response with lower risk undesirable systemic side effects. Inhaled Postnatal SteroidsThe efficacy inhaled steroids prevent BPD has already been investigated in several randomised trials, both comparison [13] placebo [14-20] .According recent systematic reviews drugs for prevention treatment BPD, there are 7 fully published controlled trials which...
Vernix caseosa protects the skin of a human fetus during last trimester pregnancy and newborn after delivery. Besides its cellular proteinaceous components, an important constituent functional agent is complex lipid fraction, implicated in multitude salubrious effects vernix caseosa. Little known about how chemical composition lipids affected by various biological characteristics baby, such as gestational age, birth weight, and, but not least, gender newborn. This study reports on...
Cholesteryl esters of ω-(O-acyl)-hydroxy FAs (Chl-ωOAHFAs) were identified for the first time in vernix caseosa and characterized using chromatography MS. Chl-ωOAHFAs isolated adsorption on silica gel magnesium hydroxide. Their general structure was established high-resolution tandem MS intact lipids, products their transesterification derivatizations. Individual molecular species nonaqueous reversed-phase HPLC coupled to atmospheric pressure chemical ionization. The analytes detected as...
Abstract We sought to determine the normocapnic values of expiratory tidal volume measured by hot‐wire anemometer, and evaluate how often exceeds estimated anatomical dead space during high‐frequency oscillatory ventilation (HFOV) in preterm infants. also relationship between other respiratory parameters. The neonatal respiration monitor SLE 2100 VPM, a was used measure expired (V T,E ) patients ventilated Sensormedics 3100A routine clinical use HFOV. Two hundred fourteen simultaneous...
Standard resuscitation guidelines are based on data from a range of gestational ages. We sought to evaluate the effectiveness our delivery room protocol across ages in preterm infants born at <29 weeks.We performed an observational study prospectively collected video recordings 73 infants. The percentage bradycardic patients, time reach target oxygen saturation and extent all interventions were compared between three age groups: 22-24 weeks (n = 22), 25-26 27) 27-28 24).Although same was...