A5030737953- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Plant-based Medicinal Research
- Lipid metabolism and disorders
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Immune cells in cancer
- Computational Drug Discovery Methods
- Sexual function and dysfunction studies
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Diet and metabolism studies
- HIV Research and Treatment
- Pancreatic function and diabetes
- Medical Research and Treatments
- T-cell and B-cell Immunology
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Immune Response and Inflammation
- Metabolism, Diabetes, and Cancer
- Bone Metabolism and Diseases
Yunnan University of Traditional Chinese Medicine
2021-2025
Yunnan Provincial Hospital of Traditional Chinese Medicine
2020-2025
Yunnan University
2009-2025
Nanjing University of Chinese Medicine
2021-2023
Affiliated Hospital of Hangzhou Normal University
2022
First Affiliated Hospital of Kunming Medical University
2021
Kunming Medical University
2021
NewYork–Presbyterian Brooklyn Methodist Hospital
2010-2012
Abstract The changes in T regulatory cell (Treg) and helper (Th) 17 ratios holds paramount importance ensuring internal homeostasis disease progression. Recently, novel subsets of Treg Th17, namely IL-17-producing IL-10-producing Th17 have been identified. are widely considered as the intermediates during Treg/Th17 transformation. These “bi-functional” cells exhibit plasticity demonstrated with important roles multiple physiological functions processes. Yin Yang represent opposing aspects...
Metabolomic analysis has been used to characterize the effects and mechanisms of drugs for nonalcoholic fatty liver disease (NAFLD) at metabolic level. Nuciferine is an active component derived from folium nelumbinis demonstrated have beneficial on a high-fat diet (HFD) induced hepatic steatosis model. However, effect altered metabolites nuciferine NAFLD not yet elucidated. In this study, we established rat model using HFD treated with nuciferine. The lipid content levels, pro-inflammatory...
Polygala japonica Houtt. (PJ) has been demonstrated with several biological potentials such as lipid-lowering and anti-inflammatory effects. However, the effects mechanisms of PJ on nonalcoholic steatohepatitis (NASH) remain unclear.The aim this study was to evaluate NASH illustrate mechanism based modulating gut microbiota host metabolism.NASH mouse model induced using methionine choline deficient (MCD) diet orally treated PJ. The therapeutic, anti-inflammatory, anti-oxidative mice were...
High complexity in precoding design for frequency division duplex systems necessitates streamlined solutions. Guided by Synesthesia of Machines (SoM), this paper introduces a heterogeneous multi-vehicle, multi-modal sensing aided scheme within vertical federated learning (VFL) framework, which significantly minimizes pilot sequence length while optimizing the system's sum rate. We address challenges posed local data heterogeneity due to varying on-board sensor configurations through...
Non-alcoholic steatohepatitis (NASH) poses a serious threat to human health. Alisol B 23-Acetate (AB23A) has shown beneficial effects on NASH, but its mechanism of action remains unclear. We conducted in vitro experiments by inducing L02 cell damage with free fatty acids (FFA) and administering various concentrations AB23A. found that AB23A intervention reduced triglyceride (TG) levels FFA-induced cells improved cellular steatosis. Transcriptomic analysis revealed significantly downregulated...
Pi-Dan-Jian-Qing decoction (PDJQ) can been used in the treatment of type 2 diabetes mellitus (T2DM) clinic. However, protective mechanisms PDJQ on T2DM remain unknown. Recent studies have shown that changes gut microbiota could affect host metabolism and contribute to progression T2DM. In this study, we first investigated therapeutic effects rats. 16S rRNA sequencing untargeted metabolomics analyses were investigate action Our results showed improve hyperglycemia, hyperlipidemia, insulin...
The aim of this study was to elucidate the mechanism nuciferine on alleviating obesity based modulating gut microbiota, ameliorating chronic inflammation, and improving permeability. In study, obese model mice were induced by high-fat diet then randomly divided into group, group; some other same week age fed with normal as group. modeling process, administered intragastrically(ig) for 12 weeks. course both treatment, body weight food intake in each group measured weekly. After Lee's index,...
The study created mice model of Hashimoto's thyroiditis (HT) and induced thyroid inflammatory cell lines, exploring the mechanism Xiaoying Daotan decoction on HT.Divided HT models into group (0.2 mL saline), Western medicine levothyroxine sodium tablets), traditional Chinese Xiaoyin prescription), Notch protein inhibition prescription). After treatment, serum expression T (Treg)/T helper 17 (Th17) cytokines levels were detected through Enzyme linked immunosorbent assay (ELISA). Use real-time...