A5100454268- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Pharmacological Effects of Natural Compounds
- Acute Ischemic Stroke Management
- Lung Cancer Research Studies
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Studies
- Thyroid Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neurological Disease Mechanisms and Treatments
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Peroxisome Proliferator-Activated Receptors
- Gastrointestinal motility and disorders
- Hepatitis B Virus Studies
- Hormonal and reproductive studies
- Pneumonia and Respiratory Infections
- Oral microbiology and periodontitis research
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
Baker Heart and Diabetes Institute
2024-2025
La Trobe University
2024-2025
Nanjing University of Posts and Telecommunications
2025
Shanxi Agricultural University
2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Shantou University
2025
Shantou University Medical College
2025
Nanjing University of Chinese Medicine
2024
Objectives To screen out the predictors of central cervical lymph node metastasis (CLNM) for papillary thyroid carcinoma (PTC) and establish a prediction model to guide operation PTC patients (cN0). Methods Data from 296 (cN0) who underwent at Second Affiliated Hospital Chongqing Medical University were collected retrospectively analyzed. They divided into two groups in accordance with CLNM or not. Their information, including ultrasound (US) features, BRAF V600E status, other...
Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of new type histone modification, methacrylation (Kmea), corresponding to structural isomer crotonyllysine. We validate identity this using diverse chemical approaches and further confirm occurrence mark by pan specific site-specific anti-methacryllysine antibodies. In total, identify 27 Kmea modified sites HeLa cells affinity enrichment...
After adulthood, as a person grows older, the secretion of sex hormones in body gradually decreases, and risk periodontitis increases. But relationship between is still controversial.
Salvianolic acid A (SAA) is a traditional Chinese medicine that has good therapeutic effect on cardiovascular disease. However, the underlying mechanisms by which SAA improves mitochondrial respiration and cardiac function in diabetic cardiomyopathy (DCM) remain unknown. This study aims to elucidate whether had any protection pathophysiology of DCM explored potential mechanisms. Diabetes was induced rats 30 mg/kg streptozotocin (STZ) treatment. After week stability, 5 isoprenaline (ISO)...
Objective: Accurate prognostic prediction in patients with high-grade aneruysmal subarachnoid hemorrhage (aSAH) is essential for personalized treatment. In this study, we developed an interpretable machine learning model aSAH using SHapley Additive exPlanations (SHAP). Methods: A prospective registry cohort of was collected one single-center hospital. The endpoint our study a 12-month follow-up outcome. dataset divided into training and validation sets 7:3 ratio. Machine algorithms,...
The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting...
Cadmium (Cd) causes a health risk to humans and animals. Exercise can prevent treat variety of diseases, but the effect mechanism exercise on cadmium poisoning are still unclear. The present research aims investigate antagonistic impacts enterotoxicity hepatotoxicity caused by Cd. results indicated that exercise, both before during Cd exposure, reduce pathological damages in liver duodenum mice, suppressing expression levels IL-1β, IL-6 TNF-α genes. In mice exposed Cd, significantly...
Introduction Ziprasidone is primarily metabolized by CYP3A4, an enzyme with genetic variability and susceptibility to inhibition or induction. This study explored the functional of CYP3A4 in ziprasidone metabolism, focusing on drug interactions polymorphisms. Methods The metabolic kinetic properties were evaluated through vitro experiments utilizing rat liver microsomes (RLM), human (HLM), baculosomes. In vivo validation studies conducted Sprague-Dawley rats. Results Quercetin significantly...
To assess the impact of pharmacist interventions on rational use prophylactic antibiotics and cost saving in elective cesarean section economic outcomes implementing interventions.A pre-to-post intervention design was applied to practices antibiotic department gynecology obstetrics a Chinese tertiary hospital. Patients admitted during 3-month period from June August 2012 that October December undergoing were assigned pre-intervention post-intervention group, respectively. Pharmacist...
Abstract We conceived of a new anti-tumor mechanism action by which soluble target in tumor microenvironment, such as tumor-driving growth factor, can be phagocytized along with cancer cells via antibody-dependent cellular phagocytosis (ADCP) using an antibody bispecific for the and solid overexpressed on cell surface. In this study, we explored conception through engineering pair antibodies (BsAbs) co-targeting human epidermal factor receptor-2 (HER2) or mouse vascular endothelial A...
Chemoradiotherapy (CRT) has been associated with increased incidence of cardiovascular (CV) adverse events (CVAE). Coronary artery calcium scoring (CAC) shown to predict coronary beyond the traditional CV risk factors. This study examines whether CAC, measured on standard care, non-contrast chest CT (NCCT) imaging, predicts development CVAE in patients non-small cell lung cancer (NSCLC) treated CRT.Patients NSCLC CRT at MD Anderson Cancer Center from 7/2009 until 4/2014 and who had least one...
miR-454-3p is considered to have a crucial role in cancer progression, but the potential involvement acute myeloid leukemia (AML) remains unclear.Expression of and ZEB2 mRNA protein were quantified AML cell lines. Cells transfected with inhibitor or mimic growth was assessed by colony formation CCK-8 assays cycle, apoptosis autophagy investigated Western blotting, flow cytometry, immunofluorescence 3-methyladenine (3-MA) treatment.miR-454-3p expression attenuated cells. overexpression...
Pulmonary fibrosis is the final outcome of a variety diffuse pulmonary interstitial diseases, and it has an unclear pathogenesis. There no effective drug treatment, so clinical prognosis poor. As component ginseng, total ginsenoside (TG) inhibits acute lung injury. This study determined whether TG protective effects on investigated its mechanisms. A model in BALB/c mice was established by injecting bleomycin chemotherapeutic agent into trachea. (40, 80, 160 mg/kg/d) given continuously for 28...
Non–small cell lung cancer (NSCLC) patients with oncogenic ROS1 rearrangements would inevitably develop drug resistance and disease progression after receiving targeted oncogene therapy. Here, we present a metastatic adenocarcinoma patient harboring CD74–ROS1 fusion who initially responded to crizotinib then developed acquiring rarely reported BRAF V600E mutation.
Background: Radiomics and artificial intelligence approaches have been developed to predict chronic obstructive pulmonary disease (COPD), but it is still unclear which approach has the best performance. Therefore, we established five prediction models that employed deep-learning (DL) radiomics-based machine-learning (ML) identify COPD on low-dose computed tomography (LDCT) images compared relative performance of different find model for identifying COPD.