A5006305384- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Radiology practices and education
- Medical Imaging and Pathology Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Renal cell carcinoma treatment
- Surgical Simulation and Training
- Cancer, Hypoxia, and Metabolism
- Cardiac Arrhythmias and Treatments
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Nanoplatforms for cancer theranostics
- Gallbladder and Bile Duct Disorders
- Venous Thromboembolism Diagnosis and Management
- Microbial Inactivation Methods
- Central Venous Catheters and Hemodialysis
- Neuroendocrine Tumor Research Advances
- Heat shock proteins research
- Ultrasound in Clinical Applications
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2016-2025
University of Mazandaran
2025
Indian Institute of Technology Delhi
2021-2025
Dr. Hari Singh Gour University
2025
Interfaith Medical Center
2025
University of Engineering and Technology Lahore
2023-2024
Hadassah Medical Center
2012-2024
Rawalpindi Medical University
2024
Aga Khan University
2024
Image-guided tumor ablation has become a well-established hallmark of local cancer therapy. The breadth options available in this growing field increases the need for standardization terminology and reporting criteria to facilitate effective communication ideas appropriate comparison among treatments that use different technologies, such as chemical (eg, ethanol or acetic acid) ablation, thermal therapies radiofrequency, laser, microwave, focused ultrasound, cryoablation) newer ablative...
To determine the long-term (10-year) survival of patients with colorectal liver metastases treated radiofrequency (RF) ablation and systemic chemotherapy intention to treat.Institutional review board approval was obtained for this study. From 1997 2006, 99 consecutive 202 small (0.8-4.0 cm; mean: 2.2 cm ± 1.1) metachronous underwent ultrasonography-guided percutaneous RF internally-cooled electrodes in association chemotherapy. Patients ineligible surgery (n = 80) or whose lesions were...
To determine whether high-dose irreversible electroporation (IRE) ablation induces thermal effects in normal liver tissue.Animal care and use committee approval was obtained prior to the experiments. IRE (n = 78) performed by a single four-person team vivo 22 porcine livers applying electric current two 1.3-cm-diameter circular flat-plate electrodes spaced 1 cm apart. Cardiac-gated pulses 40-360) were systematically applied at varying voltages (1500-2900 V). End temperatures zone center...
Background: Image-guided tumor ablation is commonly performed in clinical practice. Trying to standardize terminology and data collection enable a more reliable comparison among the different studies, 2003, document entitled "Image-Guided Tumor Ablation: Proposal for Standardization of Terms Reporting Criteria" was published by International Working Group on Image-Guided Ablation. Since then, ablations have evolved significantly, with development new technology techniques applications. This...
There is currently no consensus regarding preferred clinical outcome measures following image-guided tumor ablation or clear definitions of oncologic end points. This document proposes standardized for a broad range with recommendations on how to uniformly document, analyze, and report outcomes. The initiative was coordinated by the Society Interventional Oncology in collaboration Definition Assessment Time-to-Event End Points Cancer Trials, DATECAN, group. According predefined criteria,...
To characterize the effects of NaCl concentration on tissue electrical conductivity, radio-frequency (RF) deposition, and heating in phantoms optimize adjunctive solution injection for RF ablation an vivo model.RF was applied 12-15 minutes with internally cooled electrodes. For phantom experiments (n = 51), standardized 5% agar varied (0%-25.0%). A nonlinear simplex optimization strategy then used normal porcine liver 44) to determine optimal pre-RF parameters (concentration, 0%-38.5%;...
Radiofrequency Ablation of Hepatic Tumors: Increased Tumor Destruction with Adjuvant Liposomal Doxorubicin TherapyS. Nahum Goldberg1, Ihab R. Kamel1 2, Jonathan B. Kruskal1, Kevin Reynolds1, Wayne L. Monsky1, Keith E. Stuart3, Muneeb Ahmed1 and Vassilos Raptopoulos1Audio Available | Share
Purpose To compare both periablational and systemic effects of two mechanistically different types ablation: thermal radiofrequency (RF) ablation electroporative with irreversible electroporation (IRE) in appropriately selected animal models. Materials Methods Animal experiments were performed according to a protocol approved by the Care Committee Hebrew University. Female C57BL/6 mice (n = 165) randomized undergo either RF or IRE noncancerous normal liver. The inflammatory response, cell...
To elucidate how hepatic radiofrequency (RF) ablation affects distant extrahepatic tumor growth by means of two key molecular pathways.
Purpose To study the effects of surrounding electrical microenvironment and local tissue parameters on outcome irreversible electroporation (IRE) ablation in porcine muscle, kidney, liver tissue. Materials Methods Animal Care Use Committee approval was obtained, National Institutes Health guidelines were followed. IRE (n = 90) applied muscle 44), kidney 28), 18) 18 pigs. Two electrodes with tip exposure 1.5–2 cm used at varying voltages (1500–3000 V), pulse repetitions 70–100), length...
The quest for accurate, high-resolution, low-power-consumption, and small-footprint 3D depth cameras has driven a rapid improvement in Continuous-Wave (CW) Time-of-Flight (ToF) technology. Commercially available image acquisition techniques include Stereo Vision, Structured Light, ToF. CW ToF imaging systems offer excellent mechanical robustness, no baseline requirement, high effective resolution, low computational cost, simultaneous IR ambient light invariant intensity capture (Active...
Purpose To determine whether variable hepatic microwave ablation (MWA) can induce local inflammation and distant pro-oncogenic effects compared with radiofrequency (RFA) in an animal model. Materials Methods In this institutional Animal Care Use Committee-approved study, F344 rats (150 gm, n = 96) subcutaneous R3230 breast adenocarcinoma tumors had normal non-tumor-bearing liver treated RFA (70°C × 5 minutes), rapid higher-power MWA (20 W 15 seconds), slower lower-power (5 2 or a sham...
Hepatocellular carcinoma (HCC) with metastatic disease is associated a low survival in clinical practice. Many curative options including liver resection, transplantation, and thermal ablation are effective local but limited for patients distant metastasis. In this study, the efficacy, specificity, safety of P-selectin targeted delivery microwave (MW) responsive drug release investigated development HCC therapy. By encapsulating doxorubicin (DOX) MW sensitizer...
Facts reveal that numerous road accidents worldwide occur due to fatigue, drowsiness, and distraction while driving. Few works on the automated drowsiness detection problem, propose extract physiological signals of driver including ECG, EEG, heart variability rate, blood pressure, etc. which make those solutions non-ideal. While recent ones computer vision-based but show limited performances as either they use hand-crafted features with conventional techniques like Naïve Bayes SVM or...
Malware instances have been extremely used for illegitimate purposes, and new variants of malware are observed every day. Machine learning in network security is one the prime areas research today because its performance has shown tremendous growth last decade. In this paper, we formulate signature as a 2D image representation leverage deep approaches to characterize contained BIG15 dataset across nine classes. The current compares various machine technologies towards classification such...
Climate stress poses a threat to the agricultural sector, which is vital for both economy and livelihoods in general. Quantifying its risk food security, livelihoods, sustainability crucial. This study proposes framework estimate impact climate on agriculture terms of three objectives: assessing regional vulnerability (exposure, sensitivity, adaptive capacity), analysing variability, measuring performance under climatic stress. The twenty-two sub-regions Jammu, Kashmir, Ladakh assessed using...
Determination of Splenomegaly by CT: Is There a Place for Single Measurement?Alexandre S. Bezerra1, Giuseppe D'Ippolito2, Salomão Faintuch3, Jacob Szejnfeld2 and Muneeb Ahmed3Audio Available | Share
PURPOSE: To determine the effect of surrounding tissue type on coagulation necrosis from radiofrequency (RF) ablation in a homogeneous animal tumor model. MATERIALS AND METHODS: Thirty canine venereal sarcomas were implanted three sites (subcutaneous, kidney, and lung) 13 mildly immunosuppressed dogs. Five 25 tumors, which 19 mm ± 3 (mean SD) diameter, allocated to each five groups: (a) subcutaneous (b) kidney (c) lung tumors with blood flow, (d) (e) renal without was achieved by sacrificing...
PURPOSE: To determine whether radiofrequency (RF)-induced heating can be correlated with background electrical conductivity in a controlled experimental phantom environment mimicking different tissue conductivities and to the potential physical basis for such correlation by using computer modeling. MATERIALS AND METHODS: The effect of on RF-induced was studied system 80 two-compartment agar phantoms (with inner wells 0.3%, 1.0%, or 36.0% NaCl) that varied from 0.6% 5.0% NaCl. Mathematical...