A5101459156- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Pharmacology and Obesity Treatment
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Child Abuse and Trauma
- Genetics and Neurodevelopmental Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Noise Effects and Management
- Surgical Sutures and Adhesives
- Thyroid Disorders and Treatments
- Pain Management and Placebo Effect
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Health and Biochemistry
- Diabetes Management and Education
- Obstructive Sleep Apnea Research
- Pressure Ulcer Prevention and Management
- Body Contouring and Surgery
- Bariatric Surgery and Outcomes
- Epilepsy research and treatment
West China Hospital of Sichuan University
2016-2025
Sichuan University
2016-2025
Ningbo No. 2 Hospital
2025
Karolinska Institutet
2024
West China Medical Center of Sichuan University
2023-2024
Wenzhou Medical University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
University of Oxford
2020-2022
Oxford Centre for Diabetes, Endocrinology and Metabolism
2021-2022
After adulthood, as a person grows older, the secretion of sex hormones in body gradually decreases, and risk periodontitis increases. But relationship between is still controversial.
Abstract Background Adverse childhood experiences (ACEs), including maltreatment, have been linked with increased risk of diabetes and obesity during adulthood. A comprehensive assessment on the associations between maltreatment all major endocrine diseases, as well relative importance different proposed mechanistic pathways these associations, is currently lacking. Methods Based UK Biobank, we constructed a cohort 151,659 participants self-reported data who were 30 years age or older...
Accumulating evidence connects diverse components of body composition (e.g., fat, muscle, and bone) to neurodegenerative disease risk, yet their interplay remains underexplored. This study examines the associations between patterns risk diseases, exploring mediating role cardiovascular diseases (CVDs).
Adverse life experiences have been associated with increased susceptibilities to psychopathology in later life. However, their impact on psychological responses following physical trauma remains largely unexplored. Based the China Severe Trauma Cohort, we conducted a cohort study of 2937 patients who were admitted Medical Center West Hospital between June 2020 and August 2023. experiences, including childhood maltreatment (5 subtypes, measured by Childhood Questionnaire-Short Form) adverse...
We examined the impact of acarbose, an α-glucosidase inhibitor, on incident diabetes and regression to normoglycemia in 6,522 Acarbose Cardiovascular Evaluation (ACE) trial participants China who had impaired glucose tolerance (IGT) coronary heart disease (CHD).Participants were randomly assigned acarbose or placebo followed with four monthly fasting plasma (FPG) tests annual oral tests. Incident was defined as two successive diagnostic FPG levels ≥7 mmol/L 2-h (PG) ≥11.1 while taking study...
Diabetic cardiomyopathy is a cardiac dysfunction in patients with diabetes which may lead to overt heart failure and death. Toll-like receptor (TLR) signaling triggers diabetic through various mechanisms, one of the upregulation TLR4 expression. The aim this study was delineate role cardiomyopathy. C57BL/6 mice were injected streptozotocin induce diabetes. experimental control groups treated 5 μg small interfering RNA (siRNA) or scrambled siRNA. Cardiac histopathology evaluated by...
ObjectivesHearing impairment is common in the middle-aged population but remains largely undiagnosed and untreated. The knowledge about to what extent how hearing matters for health currently lacking. Thus, we aimed comprehensively examine adverse consequences as well comorbidity patterns of loss.Study designBased on prospective cohort UK Biobank, included 14,620 individuals (median age 61 years) with audiometry-determined (i.e., speech-in-noise test) objective loss 38,479 subjective tested...
The objective of this study was to investigate the association between developmental and premorbid body composition measurements risk motor neuron disease (MND).
Abstract GW501516‐activated peroxisome proliferator‐activated receptor (PPAR) β/δ and G‐protein‐coupled (GPR) 40 were shown to protect pancreatic β cells against lipoapoptosis. Therefore, this study aimed investigate whether activated PPARβ/δ could type 2 diabetic rats from lipoapoptosis through regulation of GPR40 compare the protective effects PPARγ. We made an animal model by feeding spontaneously Goto–Kakizaki (GK) with a high‐fat diet (HFD) evaluate on islet cell apoptosis. And, treated...
Rationale: Pheochromocytomas are rare catecholamine-secreting tumors arising from adrenomedullary chromaffin cells, usually causing hypertension, palpitation and headache. However, pheochromocytoma crisis, on the contrary, might present with hypotension, multiple organ dysfunction or even mimicking other diseases, leaving physician diagnostic difficulties. In this study, we a case featured shock syndrome admission, which nearly lead us to miss diagnosis of pheochromocytoma. Patient concerns:...
Objectives To evaluate the performance and cost-effectiveness of existing diabetes risk scores (DRSs) to screen for undiagnosed mellitus (UDM) prediabetes (PD) in a community-based southwestern Chinese population.Methods Participants TIDE-Chengdu survey with requisite data without known were included. Five Chinese-derived DRSs six non-Chinese-derived included evaluation. Their detecting UDM UMD or PD (UDM/PD) was assessed using C-statistic. The optimal DRS compared that capillary fasting...
Abstract Aims Robust diabetes risk estimates in Asian patients with impaired glucose tolerance (IGT) and coronary heart disease (CHD) are lacking. We developed a Chinese type 2 calculator using Acarbose Cardiovascular Evaluation (ACE) trial data. Methods There were 3105 placebo‐treated ACE participants requisite data for model development. Clinically relevant variables, those showing nominal univariate association new‐onset ( P < .10), entered into BASIC (clinical variables only),...
To investigate the prevalence of thyroid disorders, iodine nutritional status and relevant risk factors among adults in Chengdu city on basis two population-based surveys, one conducted between 2016 2017 other, 2019 2020, to provide references for making health-related administrative decisions.Two sampling surveys were conducted. The first was done October December 2017, using stratified cluster random select subjects from 2 urban rural communities Chengdu. Then, February sequential used...
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