A5100400502- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Metabolism and Genetic Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Cardiac Imaging and Diagnostics
- ATP Synthase and ATPases Research
- Acupuncture Treatment Research Studies
- Cardiovascular Function and Risk Factors
- Gout, Hyperuricemia, Uric Acid
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Quantum Dots Synthesis And Properties
- Cardiovascular Disease and Adiposity
- Plant Molecular Biology Research
- Chalcogenide Semiconductor Thin Films
- Cardiac electrophysiology and arrhythmias
- Vibrio bacteria research studies
- Atrial Fibrillation Management and Outcomes
- Healthcare and Venom Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
Chinese PLA General Hospital
2016-2025
Northeast Forestry University
2021-2025
Shenyang Agricultural University
2022-2025
Rice Research Institute
2022-2025
Sichuan University
2014-2025
Nankai University
2025
Nanjing University of Science and Technology
2024-2025
Capital Medical University
2023-2025
Wuhan University of Technology
2025
Zhengzhou University
2025
Polycrystalline SnSe is considered as a highly promising candidate for thermoelectric applications due to its facile processing, machinability and scale-up applications.
Piezoresistive sensors that are highly compressible, antibacterial, environmentally stable, and flexible, with exceptional sens-ing capabilities, increasingly popular in the field of practical wearable electronics. Yet, achieving their optimal perfor-mance...
Despite maternal transmission of hypertension in some pedigrees, pathophysiology maternally inherited remains poorly understood.To establish a causative link between mitochondrial dysfunction and essential hypertension.A total 106 subjects from large Chinese family underwent clinical, genetic, molecular, biochemical evaluations. Fifteen 24 adult matrilineal relatives exhibited wide range severity hypertension, whereas none the offspring affected fathers had hypertension. The age at onset...
Plants have evolved varied structures for environmental adaptation. Shoot branching, as a part of plant architecture, influences the allocation sugars produced by photosynthesis and thus greatly impacts crop yields. The activity axillary meristem, apical dominance governs shoot branching patterns. In this review, we summarize key factors involved in formation lateral branches, mechanisms how these are interconnected. particular, focus on recent advances understanding sugar signals affect...
The perivascular fat attenuation index (FAI) evaluated by coronary computed tomographic angiography (CCTA) has been reported to have strong prognostic value, but few studies focused on young people. This study aimed assess the predictive value of FAI in people suspected having atherosclerotic disease (CAD). A retrospective analysis was performed adults aged ≤ 45 years who underwent CCTA due CAD between 2015 and 2016 were followed up for at least 5 following their visit (n = 503). proximal...
Cu2Se has emerged as a promising thermoelectric material due to its low lattice thermal conductivity, high Seebeck coefficient, and peak figure of merit (ZT) at elevated temperatures. However, performance is limited by intrinsic carrier concentration mobility. In this work, we investigate Cu2Se-based composites overcome these challenges introducing GeTe compound phase optimize concentration, enhance mobility, promote phonon scattering. The incorporation significantly optimized both with the...
Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication oncogenesis in cervical cancers. HPV E6 targets tumor suppressor p53 degradation. To achieve this, "high-risk" proteins bind to modify target specificity ubiquitin ligase E6AP (E6 associated protein). This E6-dependent loss enables virus bypass host cell defenses facilitates virally induced activation cycle progression during replication. Disruption interaction between...
BACKGROUND Few studies have investigated the use of dexmedetomidine in obstetric anaesthesia. OBJECTIVE To evaluate effect combined with sufentanil for patient-controlled analgesia (PCA) after caesarean section under spinal DESIGN An interventional, randomised, double-blinded, placebo-controlled clinical study. SETTING Department Anaesthesiology, Obstetrics and Gynecology Hospital Fudan University, Shanghai, China. PATIENTS One hundred twenty parturients (American Society Anesthesiologists...
The tissue specificity of mitochondrial tRNA mutations remains largely elusive. In this study, we demonstrated the deleterious effects tRNAThr 15927G>A mutation that contributed to pathogenesis coronary artery disease. m.15927G>A abolished highly conserved base-pairing (28C-42G) anticodon stem tRNAThr. Using molecular dynamics simulations, showed caused unstable structure, supported by decreased melting temperature and slower electrophoretic mobility mutated tRNA. cybrids constructed...
Saline-alkali stress seriously affects the yield and quality of crops, threatening food security ecological security. Improving saline-alkali land increasing effective cultivated are conducive to sustainable agricultural development. Trehalose, a nonreducing disaccharide, is closely related plant growth development response. Trehalose 6-phosphate synthase (TPS) trehalose-6-phosphate phosphatase (TPP) key enzymes catalyzing trehalose biosynthesis. To elucidate effects long-term on synthesis...
Mitochondrial DNA mutations have been associated with cardiovascular disease. We report here the clinical, genetic, and molecular characterization of 1 Han Chinese family suggestively maternally transmitted hypertension. Matrilineal relatives in this exhibited variable degree hypertension at age onset 44 to 55 years old. Sequence analysis entire mitochondrial pedigree identified known homoplasmic 4435A>G mutation, which is located immediately 3 prime end anticodon, corresponding conventional...
MicroRNA205 (miR-205), as a significant tumor biomarker, is of vital importance for diagnosis lung cancer and its overexpression patterns have been extensively studied. Here, we report novel label-free nanoprobe with high sensitivity selectivity miRNA biomarker detection using localized surface plasmon resonance (LSPR) technology on single DNA modified gold nanocube (AuNC). This method allowed real-time monitoring the subtle LSPR scattering peak position's change which was aroused by...
The incidence of young coronary heart disease (CHD, ≤45 years) in China is increasing. Secondary prevention to counter this trend an important contemporary public health issure. A total 5288 patients (≤45 diagnosed with CHD and hospitalized at the Chinese PLA General Hospital Anzhen Hospital, both Beijing, were enrolled after satisfying inclusion criteria. Young increased number from 2010 2014, especially men. Among studied patients, there was no significant change over those years blood...
Ginseng, the root and rhizome of Panax ginseng C. A. Mey., is a famous herbal medicine, its major ginsenosides exert beneficial effects on nonalcoholic fatty liver disease (NAFLD). Due to multicomponent multitarget features ginsenosides, their detailed mechanisms remain unclear. This study aimed explore role NAFLD potential mediated by gut microbiota related molecular processes. C57BL/6J mice were fed high-fat diet (HFD) supplemented or not with ginsenoside extract (GE) for 12 weeks. A...
Plant architecture imposes a large impact on crop yield. IDEAL PLANT ARCHITECTURE 1 (IPA1), which encodes SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factor, is target of molecular design for improving grain However, the roles SPL factors in regulating tomato (Solanum lycopersicum) plant are unclear. Here, we show that expression SPL13 down-regulated lateral buds strigolactone (SL)-deficient ccd mutants and induced by GR24 (a synthetic analog SL). Knockout CRISPR/Cas9 resulted...
Genetic variants among individuals have been associated with ineffective control of hypertension. Previous work has shown that hypertension a polygenic nature, and interactions between these loci variations in drug response. Rapid detection multiple genetic high sensitivity specificity is needed for the effective implementation personalized medicine treatment Here, we used cationic conjugated polymer (CCP)-based multistep fluorescence resonance energy transfer (MS-FRET) technique to...
We report here on the clinical, genetic, and molecular characterization of 1 Han Chinese family with maternally transmitted hypertension. Three 7 matrilineal relatives in this 4-generation exhibited variable degree essential hypertension at age onset, ranging from 35 to 60 years old. Sequence analysis complete mitochondrial DNA pedigree identified novel homoplasmic 4401A>G mutation localizing spacer immediately 5′ end tRNA Met Gln genes 39 other variants belonging Asian haplogroup C. The...
Abstract It’s a challenge for detecting the therapeutic targets of polypharmacological drug from variations in responsed networks differentiated populations with complex diseases, as stable coronary heart disease. Here, an adaptive, 31-center, randomized, double-blind trial involving 920 patients moderate symptomatic angina treated by 14-day Danhong injection(DHI), kind high quality control, or placebo (0.9% saline), 76-day following-up, we firstly confirmed that DHI could increase...
The type VI secretion system (T6SS), a macromolecular machine, plays an important role in the pathogenicity of many Gram-negative bacteria. However, T6SS Pseudomonas syringae pv. actinidiae ( Psa ), pathogen kiwifruit bacterial canker, is yet to be studied. Here, we found gene cluster consisting 13 core genes (A-J) genome M228 based on genome-wide analysis. To determine whether affects M228, and its deletion mutants were constructed their was determined. showed different degrees reduction...