A5100629622- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Forensic Entomology and Diptera Studies
- Hearing, Cochlea, Tinnitus, Genetics
- MicroRNA in disease regulation
- Diptera species taxonomy and behavior
- Genomics and Phylogenetic Studies
- Insect behavior and control techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Insect-Plant Interactions and Control
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Insect Resistance and Genetics
- RNA regulation and disease
- Neonatal Health and Biochemistry
- Antimicrobial Peptides and Activities
- Diet and metabolism studies
- Insect and Pesticide Research
- Retinal Development and Disorders
- Circular RNAs in diseases
Qilu Hospital of Shandong University
2025
Ministry of Education of the People's Republic of China
2022-2025
Wenzhou Medical University
2007-2024
Central South University
2011-2024
Xiangya Hospital Central South University
2017-2024
Shihezi University
2024
Sichuan University
2014-2024
West China Hospital of Sichuan University
2021-2024
Second Xiangya Hospital of Central South University
2024
Zhengzhou University
2021-2024
Inter-species and intraspecific variations in mitochondrial DNA (mtDNA) were observed a bioinformatics analysis of the genomic sequences 11 animal species. Some highly conserved regions identified 12S 16S ribosomal RNA (rRNA) genes these To test whether are universally conserved, primers designed to target two used amplify from 21 tissues, including unknown origin. By sequencing PCR amplicons aligning database non-redundant nucleotide sequences, it was confirmed that aligned specifically...
Serum MMP-7 is released upon bile duct injury and has high diagnostic performance for biliary atresia.
Despite maternal transmission of hypertension in some pedigrees, pathophysiology maternally inherited remains poorly understood.To establish a causative link between mitochondrial dysfunction and essential hypertension.A total 106 subjects from large Chinese family underwent clinical, genetic, molecular, biochemical evaluations. Fifteen 24 adult matrilineal relatives exhibited wide range severity hypertension, whereas none the offspring affected fathers had hypertension. The age at onset...
Abstract Background and Aims Biliary atresia is a severe inflammatory fibrosing cholangiopathy of neonates unknown etiology. The onset cholestasis at birth implies prenatal liver dysfunction. Our aim was to investigate the mechanisms linked abnormal cholangiocyte development. Approach Results We generated biliary organoids from biopsies infants with normal diseased controls. Organoids emerged livers controls grew as lumen‐containing spheres an epithelial lining cytokeratin‐19 pos albumin neg...
α-linolenic acid (ALA), which is a member of the n-3 polyunsaturated fatty (n-3 PUFA) family, has often been ignored due to lack information. ALA gradually attracted increased attention its nutritional and medicinal advantages. Studies have shown that exerts beneficial effects on variety diseases, including cancer. In this review, we summarize antitumor in context cell biology, inhibition proliferation, induction apoptosis, metastasis angiogenesis, antioxidant effects. addition, studies can...
Exosomes are typically involved in cellular communication and signaling. Macrophages play a key role lipopolysaccharide (LPS)-induced sepsis. However, the molecular comparison of exosomes derived from LPS-induced macrophage has not been well analyzed. The macrophage-exosomes validated protein composition those investigated by isobaric tags for relative absolute quantification (iTRAQ) mass spectrometry. A total 5056 proteins identified macrophage-exosomes. We discovered 341 increased 363...
Mitochondrial DNA mutations have been associated with cardiovascular disease. We report here the clinical, genetic, and molecular characterization of 1 Han Chinese family suggestively maternally transmitted hypertension. Matrilineal relatives in this exhibited variable degree hypertension at age onset 44 to 55 years old. Sequence analysis entire mitochondrial pedigree identified known homoplasmic 4435A>G mutation, which is located immediately 3 prime end anticodon, corresponding conventional...
Anxiety, depression, and sleep problems are prevalent comorbid mental disorders among university students. The World Health Organization (WHO) emphasized a health promotion objective, recommending the consideration of protective health-promoting factors in strategies aimed at preventing disorders. Integrating theoretically significant constructs (such as factors) enhances our comprehension intricate mechanisms that underpin This study employed network analysis to first identify core bridge...
We report here on the clinical, genetic, and molecular characterization of 1 Han Chinese family with maternally transmitted hypertension. Three 7 matrilineal relatives in this 4-generation exhibited variable degree essential hypertension at age onset, ranging from 35 to 60 years old. Sequence analysis complete mitochondrial DNA pedigree identified novel homoplasmic 4401A>G mutation localizing spacer immediately 5′ end tRNA Met Gln genes 39 other variants belonging Asian haplogroup C. The...
Abstract Mitochondria synthesize select phospholipids but lack the machinery for synthesis of most abundant mitochondrial phospholipid, phosphatidylcholine (PC). Although phospholipid transfer protein Stard7 promotes uptake PC by mitochondria, importance this pathway and cellular homeostasis represents a significant knowledge gap. Haploinsufficiency is associated with exacerbation allergic airway disease in mice, including an increase epithelial barrier permeability. To test hypothesis that...
Abstract Aims/hypothesis High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was rediscovered to be a ‘danger signal’ (alarmin) that alerts the immune system once released extracellularly. Therefore, it has been recognised contributing pathogenesis of autoimmune diabetes, but its exact impact on initiation and progression type as well related molecular mechanisms, are yet fully characterised. Methods In current report, we employed NOD mice model dissect...
Mutations in mitochondrial DNA (mtDNA), particularly those the 12S rRNA gene, have been shown to be associated with sensorineural hearing loss. Recently, a systematic and extended mutation screening of gene has initiated large clinical population Otology Clinic at Chinese PLA General Hospital aim identifying mtDNA mutations Here we report molecular characterization patient auditory neuropathy. Sequence analysis this identified T-to-C transition position 1095 (T1095C) other nucleotide...
Abstract Evidence indicates that the induction of cyclooxygenase-2 (COX-2) and high prostaglandin E2 (PGE2) levels contribute to pathogenesis non–small-cell lung cancer (NSCLC). In addition overproduction by COX-2, PGE2 concentrations also depend upon catabolic enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). We find a dramatic down-regulation PGDH protein in NSCLC cell lines resected human tumors when compared with matched normal lung. Affymetrix array analysis 10 tissue samples 49...
To investigate the role of mitochondrial modifiers in development deafness associated with 12S rRNA A1555G mutation.
Mutations in mitochondrial DNA (mtDNA) have been associated with hypertension several pedigrees maternal inheritance. However, the pathophysiology of maternally inherited remains poorly understood. We reported here clinical, genetic evaluations and molecular analysis mtDNA a three-generation Han Chinese family essential hypertension. Eight 17 matrilineal relatives exhibited wide range severity hypertension, whereas none offsprings affected father had The age-at-onset kindred varied from 31...