A5100363321- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Biological Activities
- Natural Compound Pharmacology Studies
- Metabolomics and Mass Spectrometry Studies
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- melanin and skin pigmentation
- Atherosclerosis and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Extracellular vesicles in disease
- Genomics and Phylogenetic Studies
- Plant Pathogens and Fungal Diseases
- Cancer-related gene regulation
- RNA modifications and cancer
- Microbial Community Ecology and Physiology
- CRISPR and Genetic Engineering
- Remote Sensing and LiDAR Applications
- Diabetes and associated disorders
- Viral-associated cancers and disorders
- Bone and Joint Diseases
- Studies on Chitinases and Chitosanases
Sun Yat-sen University
2020-2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Guiyang Medical University
2023-2025
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2025
Central South University
2019-2024
Tongji Hospital
2022-2024
Huazhong University of Science and Technology
2016-2024
Hunan Cancer Hospital
2020-2024
Affiliated Hospital of Southwest Medical University
2022-2024
South China University of Technology
2024
Abstract Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated various tumor tissues plays important roles formation, metastasis, drug resistance. STAT3 considered potential subtarget for therapy. Noncoding RNA (ncRNA) special type transcript. Transforming from “junk” transcripts into molecules involved cell apoptosis, growth, functional regulation, ncRNA has been proven to be closely related epithelial–mesenchymal...
Abstract Early metastasis is the primary factor in very poor prognosis of pancreatic ductal adenocarcinoma (PDAC), with liver being most common form distant PDAC. To investigate mechanism PDAC metastasis, we found that cells can promote formation pre-metastatic niches (PMNs) through exosomes to facilitate early stage. In our study, hepatic stellate (HSCs) were treated PDAC-derived (PDAC-exo), and activation HSCs was detected. A novel transfer RNA-derived fragment, tRF-GluCTC-0005 obtained by...
α-linolenic acid (ALA), which is a member of the n-3 polyunsaturated fatty (n-3 PUFA) family, has often been ignored due to lack information. ALA gradually attracted increased attention its nutritional and medicinal advantages. Studies have shown that exerts beneficial effects on variety diseases, including cancer. In this review, we summarize antitumor in context cell biology, inhibition proliferation, induction apoptosis, metastasis angiogenesis, antioxidant effects. addition, studies can...
Abstract Previous study has explored that SNHG16, a long non-coding RNA (lncRNA), mediated cell growth and proliferation. Yet, the role of SNHG16 in human colorectal cancer (CRC) still remains to be explored. Therefore, we conducted present explore functions CRC. In study, was significantly up-regulated CRC tissues lines. Gain- loss-of-function further presented promoted progression cells, including proliferation, migration, invasion. Further, vivo also revealed overexpression could promote...
Liquid-liquid phase separation (LLPS) enhances oncogenic signaling pathways and advances cancer progression, has been proposed as a promising biomarker intervention target. Nevertheless, doubts remain about the prognostic importance of LLPS-related long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC). Methods: An lncRNA signature was generated by drivers regulators LLPS, validated external datasets. The underlying genetic changes functional enrichment were assessed. drug...
Genetic elements are foundational in synthetic biology serving as vital building blocks. They enable programming host cells for efficient production of valuable chemicals and recombinant proteins. The unfolded protein response (UPR) is a stress pathway which the transcription factor Hac1 interacts with upstream element (UPRE) promoter to restore endoplasmic reticulum (ER) homeostasis. Here, we created UPRE2 mutant (UPRE2m) library. Several rounds screening identified many enhanced...
Hypericumonates A–C, the first α-pyrone meroterpenoid dimers with two motifs (a 6/6/4-6/6 ring system) connected via C-8–C-9, were isolated from Hypericum monogynum . (+)-1 exhibited good anti-neuroinflammatory activity.
Bacterial biofilms do serious harm to the diabetic foot ulcer (DFU) because they play a crucial role in infection invasion and spread. Staphylococcus aureus, predominant Gram-positive bacteria (DFI), is often associated with colonization biofilm formation. Through formation tests vitro, we observed that S. aureus isolated from DFU wounds were more prone form than those non-diabetic patients, while there was no difference blood sugar between (+) diabetics (DB+) (-) (DB-). Furthermore, found...
Glucose transporter 4 (GLUT4) is a dominant regulator of whole-body glucose homeostasis. Accumulating evidence has shown that circular RNAs (circRNAs) play significant roles in the pathogenesis disease. The aim present study was to identify circRNA can be used as novel biomarker for type 2 diabetes (T2D) through regulating GLUT4. Based on previous microarray analysis comparing T2D cases and healthy controls, hsa_circ_0071336, which predicted GLUT4 by acting competitive endogenous (ceRNA)...
Our previous study showed that neuronal apoptosis was significantly increased upon treatment of conditioned medium (CM) from necroptotic astrocytes (NAS), leaving the underlying mechanism unclear. Considering nutritive and supportive roles astrocytes, we first examined neurotrophic phenotype with focus on glial cell line-derived factor (GDNF) brain-derived (BDNF), two important factors, it unexpectedly found expression GDNF BDNF were up-regulated in vitro. A question raised as to whether...