A5047959370- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Stroke Rehabilitation and Recovery
- Nanoplatforms for cancer theranostics
- Pelvic and Acetabular Injuries
- Connective tissue disorders research
- Spinal Hematomas and Complications
- Wound Healing and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced Photocatalysis Techniques
- Minerals Flotation and Separation Techniques
- Fibroblast Growth Factor Research
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Ubiquitin and proteasome pathways
- Oral and Maxillofacial Pathology
- Developmental Biology and Gene Regulation
- Plant biochemistry and biosynthesis
- Circadian rhythm and melatonin
Guangdong Provincial People's Hospital
2019-2025
Guangdong Academy of Medical Sciences
2017-2025
Southern Medical University
2023-2025
Central South University
2024
Harvard Stem Cell Institute
2023
Shaanxi Normal University
2021
Sun Yat-sen Memorial Hospital
2011-2020
Sun Yat-sen University
2010-2020
Guangdong General Hospital
2017-2019
Hypertrophic differentiation is not only the terminal process of endochondral ossification in growth plate but also an important pathological change osteoarthritic cartilage. Collagen type II (COL2A1) was previously considered to be a structural component cartilage matrix, recently, it has been revealed extracellular signaling molecule that can significantly suppress chondrocyte hypertrophy. However, mechanisms by which COL2A1 regulates hypertrophic remain unclear. In our study, Col2a1...
Intramembranous ossification and endochondral are two ways through which bone formation fracture healing occur. Accumulating amounts of evidence suggests that melatonin affects osteoblast differentiation, but little is known about the effects on process chondrogenic differentiation. In this study, human mesenchymal stem cells (MSCs) undergoing differentiation were investigated. Cells induced along via high-density micromass culture in medium containing vehicle or 50 nm melatonin....
Correct notochord and neural tube (NT) formation is crucial to the development of central nervous system midline structures. Integrated biochemical biophysical signaling controls embryonic growth patterning; however, underlying mechanisms remain poorly understood. Here, we took opportunities marked morphological changes during NT identified both necessary sufficient roles Yap, a key mechanosensor mechanotransducer, in activation floor plate, ventral centers that pattern dorsal-ventral axis...
Background Adolescent idiopathic scoliosis (AIS) is one of the most common spinal deformities found in adolescent populations. Recently, a genome-wide association study (GWAS) Japanese population indicated that three single nucleotide polymorphisms (SNPs), rs11190870, rs625039 and rs11598564, all located near LBX1 gene, may be associated with AIS susceptibility [1]. This suggests novel predisposition candidate gene supports hypothesis somatosensory functional disorders could contribute to...
Abstract Chronic diabetic wounds pose significant challenges due to uncontrolled bacterial infections, prolonged inflammation, and impaired angiogenesis. The rapid advancement of photo‐responsive antibacterial therapy shows promise in addressing these complex issues, particularly utilizing 2D heterojunction materials, which offer unique properties. Herein, an situ sprayed Bi/BiOCl 0D/2D composite fibrin gel with the characteristics formation effective near‐infrared activation is designed for...
The collagen type II alpha 1 (COL2A1) mutation causes severe skeletal malformations, but the pathogenic mechanisms of how this occurs are unclear. To understand may happen, a col2a1 p.Gly1170Ser mutated mouse model was constructed and in homozygotes, chondrodysplasia phenotype observed. Misfolded procollagen largely synthesized retained dilated endoplasmic reticulum stress (ERS)-unfolded protein response (UPR)-apoptosis cascade activated. Apoptosis occurred prior to hypertrophy, prevented...
A retrospective study of magnetic resonance imaging the lower lumbar spine.To describe characteristics concave angle vertebral endplate (CAVE) and association between CAVE intervertebral disc degeneration (IVDD).The is responsible for transferring stress body, its concavity important in dispersing compression stress. However, relationship IVDD have not been investigated.Magnetic images spine 511 patients with low back pain were examined by 2 experienced surgeons. The grades herniation (LDH)...
The purpose of this study is to explore the therapeutic effect percutaneous kyphoplasty (PKP) combined with anti-osteoporosis drug, zoledronic acid, on postmenopausal women osteoporotic vertebral compression fracture (OVCF) and perform an analysis postoperative bone cement leakage risk factors.A total 112 OVCF patients, according regimens, were divided into control group (n = 52, treated PKP) observation 60, PKP acid injection).Postoperative tumor necrosis factor-α interleukin-6 levels...
Abstract The functions of long (>200 nt) non-coding RNA (lncRNA) small nucleolar host gene 1 (SNHG1) have only been investigated in cancer biology. We found that plasma LncRNA SNHG1 was down-regulated postmenopausal than premenopausal females. Among females, the ones with osteoporosis showed much lower expression levels lncRNA SNHG1. A 6-year follow-up study on females revealed decreased but not healthy Levels at 12 months before diagnosis is sufficient to distinguish patients from...
The supplemental harvesting of in-situ bone obtained from cervical vertebrae as cage-filling material in anterior discectomy and fusion (ACDF) results a good outcome. This study aimed to further quantitatively evaluate the obtainable volume clinical outcomes autogenous grafting based on three-dimensional (3D) preoperative simulation. included 78 patients who underwent single-level ACDF. Prior surgical procedure, 3D simulated surgery was performed by constructing several cutting planes Mimics...
Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide. Multi-modal MRI data is crucial for accurate tumor segmentation, but missing modalities common in clinical practice can severely degrade the segmentation performance. While incomplete multi-modal learning methods attempt address this, robust discriminative features from arbitrary remains challenging. To this challenge, we propose a novel Semantic-guided Masked Mutual Learning (SMML) approach...
Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, leptin levels AIS girls are still discrepancy, and no vitro study is reported. We took series case-control studies, trying understand whether gene polymorphisms involved or change level secondary event, assess receptor, evaluate differences response between cases controls. screened all exons 45 controls selected six tag SNPs cover observed variations. Association analysis 446 patients...
Bacterial biofilms do serious harm to the diabetic foot ulcer (DFU) because they play a crucial role in infection invasion and spread. Staphylococcus aureus, predominant Gram-positive bacteria (DFI), is often associated with colonization biofilm formation. Through formation tests vitro, we observed that S. aureus isolated from DFU wounds were more prone form than those non-diabetic patients, while there was no difference blood sugar between (+) diabetics (DB+) (-) (DB-). Furthermore, found...
Intervertebral disc degeneration (IVDD) is an important risk factor of low back pain. We previously found upregulated markers fibrosis, the late stage chronic inflammation, in degenerated IVD with a small number clinical specimens. Here, we aimed to study on larger scale association cyclooxygenase 2 (COX2), inflammation and/or pain marker, IVDD. This involved 107 LBP participants. The level was graded 1-5 according Pfirrmann classification system. Discs at grades 1-3 were further grouped as...
Postsurgical infection of orthopedic fixation materials is considered to be the main cause failure. To address problem, clinical treatment often relies on long-term antibiotics, secondary surgery, and so forth, which pain suffering patients. Constructing a light-responsive surface structure implant has attracted widespread attention for management postsurgical infections because its noninvasiveness controllability. Nevertheless, application structures implants still limited by their unsafety...
Cervical spondylotic myelopathy (CSM) has a high incidence in the middle-aged and elderly people. According to clinical research, there is connection between hand dexterity cervical nerves. So surgeon makes preliminary assessment of severity CSM based on 10-second grip release (G&R) test. At present, statistics G&R test rely surgeon's manual counting. When patient's motion speed too fast, counting prone error, leading potential misdiagnosis. On other hand, recent years, artificial...
Mesenchymal stem cells (MSCs) are multipotent that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying of MSCs remains largely unknown and thus hinders further development MSC-based cell therapies for bone repair in clinic. RSP5, also called NEDD4L (NEDD4-like E3 ubiquitin protein ligase), belongs to HECT (homologous E6-AP carboxyl terminus) domain-containing ligase family. Nevertheless, although many studies been conducted elucidate role RSP5...
To investigate the optimal anticoagulation methods and monitoring strategy for Chinese patients undergoing heart valve replacement, which is potentially quite different from western populations.In this multicenter prospective cohort study, data was acquired 25 773 in-hospital in 35 medical centers 20 519 outpatient clinic 11 January 1st, 2011 to December 31th, 2015.As patients, mean age of study population (48.6±11.2) years old; main etiology pathology rheumatic (87.5%) origin among cohort;...
Study Design. A prospective cohort study. Objective. To compare the radiological outcomes between three-level anterior cervical discectomy and fusion (ACDF) plate-only open-door laminoplasty (LAMP) in patients with lordotic spine. Summary of Background Data. Both ACDF LAMP are important surgical methods for multilevel spondylotic myelopathy, but sagittal alignment lordosis preserving abilities two specific approaches have not been carefully compared. Methods. Sixty patients, all whom had...
Thoracolumbar burst fractures can be treated with posterior short-segment fixation. However, no classification help to estimate whether the healed vertebral body will have sufficient stability after implant removal. We aimed develop a Healing Pattern Classification (HPC) evaluate of vertebra based on cavity size and location.
Hand clumsiness and reduced hand dexterity can signal early signs of degenerative cervical myelopathy (DCM). While the 10-second grip release (10-s G&R) test is a common clinical tool for evaluating function, more accessible method warranted. This study explores use deep learning-enhanced (DL-HGRT) predicting DCM evaluates its capability to reduce duration 10-s G&R test.