A5100645738- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Vestibular and auditory disorders
- Bone Metabolism and Diseases
- Asthma and respiratory diseases
- Genomic variations and chromosomal abnormalities
- Biochemical and Molecular Research
- Liver Disease and Transplantation
- Antimicrobial Peptides and Activities
- Diet, Metabolism, and Disease
- Viral-associated cancers and disorders
- interferon and immune responses
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Genetic Associations and Epidemiology
- Lymphoma Diagnosis and Treatment
- Ear Surgery and Otitis Media
- Health, psychology, and well-being
- Fibroblast Growth Factor Research
- IL-33, ST2, and ILC Pathways
Xuzhou Medical College
2025
Hainan Medical University
2024
Zhongda Hospital Southeast University
2023
Zhejiang University
2013-2022
Children's Hospital of Zhejiang University
2016-2022
Fujian Medical University
2017-2022
Union Hospital
2017-2022
Children's Hospital
2016-2020
Xinqiao Hospital
2019
Army Medical University
2019
ABSTRACT Disulfidptosis, a new form of programmed cell death, plays role in multiple types cancer. However, research on disulfidptosis glioma is lacking. A disulfidptosis‐associated risk score was constructed using Cox regression modelling, while LASSO applied for feature selection. To explore the relationship between and immune microenvironment, we employed CIBERSORT, ssGSEA ESTIMATE algorithms. Additionally, wet lab experiments were conducted to validate functional key gene RPN1,...
Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 chitin-binding glycoprotein with unclear functions, but its expression associated inflammation and tissue remodeling. However, few studies have explored whether inflammatory phenotypes of asthma. The study had two parts. Study I (n = 115) was one-year prospective cohort designed to explore the relationship serum levels asthma at baseline, during exacerbations. II 62) four-week define...
Mutations in Gap Junction Beta 2 (GJB2) have been reported to be a major cause of non-syndromic hearing loss many populations worldwide. The spectrums and frequencies GJB2 variants vary substantially among different ethnic groups, the genotypes these remain poorly understood. In present study, we carried out systematic extended mutational screening gene 1067 Han Chinese subjects with loss, resultant were evaluated by phylogenetic, structural bioinformatic analysis. A total 25 (23 known...
In this report, we investigated the pathogenic mechanism underlying deafness-associated mitochondrial(mt) tRNAAsp 7551A > G mutation. The m.7551A mutation is localized at a highly conserved nucleotide(A37), adjacent (3') to anticodon, which important for fidelity of codon recognition and stabilization in functional tRNAs. It was anticipated that altered structure function mt-tRNAAsp primer extension assay demonstrated created m1G37 modification Using cybrid cell lines generated by...
Abstract Defects in the posttranscriptional modifications of mitochondrial tRNAs have been linked to human diseases, but their pathophysiology remains elusive. In this report, we investigated molecular mechanism underlying a deafness-associated tRNAIle 4295A>G mutation affecting highly conserved adenosine at position 37, 3′ adjacent tRNA’s anticodon. Primer extension and methylation activity assays revealed that m.4295A>G introduced tRNA methyltransferase 5 (TRMT5)-catalyzed...
The pathophysiology underlying spiral ganglion cell defect–induced deafness remains elusive. Using the whole exome sequencing approach, in combination with functional assays and a mouse disease model, we identified potentially novel deafness-causative MAP1B gene encoding highly conserved microtubule-associated protein. Three heterozygous mutations (c.4198A>G, p.1400S>G; c.2768T>C, p.923I>T; c.5512T>C, p.1838F>L) were cosegregated autosomal dominant inheritance of nonsyndromic sensorineural...
Mutations in the mitochondrial tRNAs have been reported to be important cause of hearing loss. However, only a few cases identified thus far and prevalence tRNA mutations hearing-impaired patients remain unclear. Here we performed mutational analysis 22 genes large cohort 887 Han Chinese subjects with loss by Sanger sequencing. The systemic evaluation putative pathogenic variants was further carried out frequency controls (<1%), phylogenetic analysis, structural...
Abstract In this report, we investigated the molecular mechanism underlying a deafness-associated m.5783C &gt; T mutation that affects canonical C50-G63 base-pairing of TΨC stem tRNACys and immediately adjacent to 5′ end light-strand origin mitochondrial DNA (mtDNA) replication (OriL). Two dimensional agarose gel electrophoresis revealed marked decreases in intermediates including ascending arm Y-fork arcs spanning OriL mutant cybrids bearing mutation. mtDNA alterations were further...
Abstract Background Non-alcohol fatty liver disease (NAFLD) is the most common and an unhealthy lifestyle can lead to increased risk of NAFLD. The present study aims evaluate association meat consumption with NAFLD liver-related biochemical indexes in middle-aged elderly Chinese. Methods A cross-sectional was conducted individuals who were 45 years or older underwent a physical examination from April 2015 August 2017 Southeast China. To associations between intake risk, inverse probability...
Gestational diabetes mellitus is one of the most frequent metabolic complications pregnancy. Previous studies have reported that using either probiotic yogurt or a supplement reduces incidence gestational diabetes. However, results were inconsistent. Thus, aim present study was to investigate association between and intake during pregnancy pre-pregnancy in Chinese women.This case-control involving 123 cases with 126 controls matched for age body mass index. Each participant interviewed...